J Cancer Prev.
2024 Dec;29(4):105-112. 10.15430/JCP.24.015.
Challenges in Metabolite Biomarkers as Avenues of Diagnosis and Prognosis of Cancer
- Affiliations
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- 1Cancer and Translational Research Lab, Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Pune, India
- 2Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pune, India
- 3Department of Biotechnology, Sri Venkateswara College of Engineering, Sriperumbudur, India
- KMID: 2564111
- DOI: http://doi.org/10.15430/JCP.24.015
Abstract
- Given the evolutionary nature of tumor complexities and heterogeneity, the early diagnosis of cancer encounters various challenges. Complexities at the level of metabolite reprogramming are compelling in the background of invasiveness, metastasis, drug- and radiation-induced metabolic alterations, immunotherapy-influenced changes, and pro-tumor niche including microbiome. Therefore, it is crucial to examine both current and future obstacles associated with early cancer detection specifically in the context of tumor metabolite biomarkers at preclinical and clinical levels. In conclusion, the significance of tumor metabolite biomarkers must be aligned with a comprehensive approach to achbieve diagnosis and prognosis of cancer patients by securing solutions to formidable challenges.
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