J Cancer Prev.  2024 Dec;29(4):99-104. 10.15430/JCP.24.026.

Evolving Therapeutic Strategies in Esophageal Squamous Cell Carcinoma: Advances and Perspectives

• Liu Z
• Kim MO

• KMID: 2564110
• DOI: http://doi.org/10.15430/JCP.24.026

Abstract

Esophageal squamous cell carcinoma (ESCC) is among the most prevalent forms of esophageal cancer globally, with a particularly high incidence in developing countries. Notably, Asia accounts for approximately 80% of global esophageal cancer cases, with China alone contributing to 54% of this burden. The primary treatment modality for ESCC remains esophagectomy, primarily employed for locally advanced disease, often in combination with chemotherapy and radiotherapy for advanced-stage cases. Despite significant advancements in surgical techniques and the advent of precision medicine, which has facilitated the development of targeted and immune-based therapies, critical challenges persist, including suboptimal therapeutic efficacy and the emergence of drug resistance. A comprehensive understanding of the current treatment landscape for ESCC is essential to overcoming these barriers and improving patient outcomes.

Keyword

Esophageal squamous cell carcinoma; General Surgery; Chemotherapy; Radiotherapy