Korean J Gastroenterol.  2014 Jun;63(6):366-368. 10.4166/kjg.2014.63.6.366.

Pseudoepitheliomatous Hyperplasia Mimicking Esophageal Squamous Cell Carcinoma in a Patient with Lye-induced Esophageal Stricture

• Han JS
• Lee SW
• Suh KH
• Kim SY
• Hyun JJ
• Jung SW
• Koo JS
• Yim HJ

• KMID: 2234038
• DOI: http://doi.org/10.4166/kjg.2014.63.6.366

Abstract

Pseudoepitheliomatous hyperplasia is a benign condition that may be caused by prolonged inflammation, chronic infection, and/or neoplastic conditions of the mucous membranes or skin. Due to its histological resemblance to well-differentiated squamous cell carcinoma, pseudoepitheliomatous hyperplasia may occasionally be misdiagnosed as squamous cell carcinoma. The importance of pseudoepitheliomatous hyperplasia is that it is a self-limited condition that must be distinguished from squamous cell carcinoma before invasive treatment. We report here on a rare case of esophageal pseudoepitheliomatous hyperplasia in a 67-year-old Korean woman with a lye-induced esophageal stricture. Although esophageal pseudoepitheliomatous hyperplasia is infrequently encountered, pseudoepitheliomatous hyperplasia should be considered in the differential diagnosis of esophageal lesions.

Keyword

Pseudoepitheliomatous hyperplasia; Squamous cell carcinoma; Esophagus

MeSH Terms

Aged
Carcinoma, Squamous Cell/diagnosis
Diagnosis, Differential
Esophageal Neoplasms/diagnosis
Esophageal Stenosis/chemically induced/*diagnosis
Esophagoscopy
Female
Humans
Hyperplasia/*diagnosis/pathology
Iodides/chemistry
Lye/*toxicity
Iodides
Lye

Figure

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  Fig. 1. Endoscopic view of the esophagus showing an intraluminal protruding mass 25 cm from the incisor teeth during: (A) an initial esophagogastroduodenoscopy; (B) a surveillance esophagogastroduodenoscopy performed after two months.

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  Fig. 2. Lugol chromoscopy showing the mucosal lesion stained with Lugol's solution.

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  Fig. 3. Histological view of the esophageal mucosal lesion showing prominent hyperplasia of the epithelium (H&E, ×100).

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  Fig. 4. Immunohistochemical view of the esophageal mucosal lesion showing staining limited to the basal layer of benign epithelium with: (A) Ki67 immunostain (×200); (B) p53 immunostain (×200).

Reference

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