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Thermosensitive Hydrogel Loaded with Primary ChondrocyteDerived Exosomes Promotes Cartilage Repair by Regulating Macrophage Polarization in Osteoarthritis

Sang X, Zhao X, Yan L, Jin X, Wang X, Wang J, Yin Z, Zhang Y, Meng Z

BACKGROUND: Intra-articular injection is a classic strategy for the treatment of early osteoarthritis (OA). However, the local delivery of traditional therapeutic agents has limited benefits for alleviating OA. Exosomes, an...
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Accuracy of Surgical Robot System Compared to Surgical Guide for Dental Implant Placement: A Pilot Study

Jin X, Kim RJY, Park JM, Jung UW, Cha JK, Shim JS, Heo SJ

Purpose: This study aimed to evaluate the tracking accuracy of a robot-guided implant surgery system and compare the spatial accuracy of robot-assisted implant surgery with that of static stentguided implant...
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Mediation analysis of leisure activities on the association between cognitive function and mortality: a longitudinal study of 42,942 Chinese adults 65 years and older

Chen X, Wu W, Zhang X, Long T, Zhu W, Hu R, Jin X, Yan LL, Yao Y

study aimed to evaluate whether leisure activities causally mediate these associations. METHODS: This longitudinal study included 42,246 participants aged over 65 years from the Chinese Longitudinal Healthy Longevity Survey. The Mini-Mental...
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Umbilical Cord Mesenchymal Stem Cells for Inhibiting the Fibrosis and Autoimmune Development in HOCl-Induced Systemic Scleroderma Mouse Model

Jin X, Hou J, Zheng K, Wei D, Zhang A, Wang S, Mei H, Li C, Cheng L, Sun X

Background and Objectives: Systemic scleroderma (SSc) is a rare and serious connective tissue disease, an autoimmune disease, and a rare refractory disease. In this study, preventive effect of single systemic...
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Factors Influencing COVID-19 Preventive Behaviors in Nursing Students: Knowledge, Risk Perception, Anxiety, and Depression

Lee SJ, Jin X, Lee S

Purpose: The purpose of this study was to survey the Coronavirus Disease 2019 (COVID-19) related knowledge, risk perception, preventive behaviors, depression, and anxiety levels among nursing students, and to identify...
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Psychological Resilience of Second-Pregnancy Women in China: A Cross-sectional Study of Influencing Factors

Jin X, Xu X, Qiu J, Xu Z, Sun L, Wang Z, Shan L

Purpose: The aim of the study was to evaluate the status of psychological resilience among women in their second pregnancy and to investigate the possible influencing factors. Methods: A total of...
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Intervention for Married Immigrant Women in Korea: A Systematic Review

Lee SJ, Jin X, Lee S

Purpose: This study aimed to review the intervention programs designed for married immigrant women living in Korea. Methods: A total of 39 articles published from 2010 to 2020 were selected and...
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Efficacy of Evolocumab in Patients with Hypercholesterolemia

Jin X, Kim MH, Cho YR, Park JS, Song K, Yuan SL

Objectives: The FOURIER trial reported that inhibition of PCSK9 with evolocumab on a background of statin therapy lowered low-density lipoprotein (LDL) cholesterol levels to a median of 30 mg per...
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Porcine parvovirus nonstructural protein NS1 activates NF-κB and it involves TLR2 signaling pathway

Jin X, Yuan Y, Zhang C, Zhou Y, Song Y, Wei Z, Zhang G

Background: Porcine parvovirus (PPV) is a single-stranded DNA virus that causes porcine reproductive failure. It is of critical importance to study PPV pathogenesis for the prevention and control of the...
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Pharmacokinetics and pharmacodynamics of a fixed-dose combination of gemigliptin/metformin sustained release 25/500 mg compared to the loose combination in healthy male subjects

Jin X, Kim E, Huh KY, Hwang I, Cho JY, Yu KS, Lee S

A fixed-dose combination (FDC) of gemigliptin/metformin can improve the medication adherence in patients with type 2 diabetes mellitus (T2DM). In this study, the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of...
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Possibility of pharmacokinetic drug interaction between a DPP-4 inhibitor and a SGLT2 inhibitor

Gu N, Park SI, Chung H, Jin X, Lee S, Kim TE

Type 2 diabetes mellitus is a multifactorial condition characterized by high level of sugar in the blood. To control hyperglycemia, combination therapy is recommended if monotherapy fails to achieve glycemic...
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Spatiotemporal Profile and Morphological Changes of NG2 Glia in the CA1 Region of the Rat Hippocampus after Transient Forebrain Ischemia

Jin X, Riew TR, Kim S, Kim HL, Lee MY

Neuron-glial antigen-2 (NG2) glia undergo proliferation and morphological changes following brain insults. Here, we show that NG2 glia is activated in a characteristic time- and layer-specific manner in the ischemia-vulnerable...
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Time-dependent reversal of significant intrapulmonary shunt after liver transplantation

Jin X, Sun BJ, Song JK, Roh JH, Jang JY, Kim DH, Lim YS, Song JM, Kang DH, Lee SG

BACKGROUND/AIMS: Although the association between intrapulmonary shunt (IPS) and liver cirrhosis is clear, data of repeated contrast echocardiography (CE) before and after liver transplantation (LT) to evaluate factors associated with...
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Combined Let-7a and H19 Signature: A Prognostic Index of Progression-Free Survival in Primary Breast Cancer Patients

Guo Q, Wen R, Shao B, Li Y, Jin X, Deng H, Wu J, Su F, Yu F

PURPOSE: The long non-coding RNA H19, a conservatively imprinted gene, acts as a molecular sponge for the let-7 family, which has been identified as a set of tumor suppressors. However,...
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Clinical Characteristics of Korean Patients with Bicuspid Aortic Valve Who Underwent Aortic Valve Surgery

Sun BJ, Jin X, Song JK, Lee S, Lee JH, Park JB, Lee SP, Kim DH, Park SJ, Kim YJ, Cho GY, Song JM, Kang DH, Sohn DW

BACKGROUND AND OBJECTIVES: Clinical data for Korean patients with bicuspid aortic valve (BAV) that underwent aortic valve (AV) surgery are currently limited. METHODS: Data for 1,160 consecutive adult BAV patients who...
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Investigating the Prevalence of Dementia and Its Associated Risk Factors in a Chinese Nursing Home

Xu S, Jin X, Liu C, Jin Y, Xu Y, Chen L, Xu S, Tang H, Yan J

BACKGROUND AND PURPOSE: The objective of this study was to determine the prevalence of and risk factors for dementia in residents aged 65 years and older in a Chinese nursing...
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Chief Complaints of Elderly Individuals on Presentation to Emergency Department: A Retrospective Analysis of South Korean National Data 2014

Song M, Jin X, Ko HN, Tak SH

PURPOSE: We aimed to assess the chief complaints (CCs) of elderly individuals on presentation to the emergency department (ED) according to gender, age, and disease-related and injury-related visits. METHODS: The 2014...
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Acculturation Stress and Health Promotion Behaviors of the Korean Chinese Elderly Immigrants Living in Korea

Jin X, Song M

PURPOSE: This study examined the relationship between acculturation stress and health promotion behaviors in the Korean Chinese elderly immigrants living in Korea, focusing on the buffering effects of social support. METHODS:...
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Changes in the Expression and Distribution of Claudins, Increased Epithelial Apoptosis, and a Mannan-Binding Lectin-Associated Immune Response Lead to Barrier Dysfunction in Dextran Sodium Sulfate-Induced Rat Colitis

Yuan B, Zhou S, Lu Y, Liu J, Jin X, Wan H, Wang F

BACKGROUND/AIMS: This animal study aimed to define the underlying cellular mechanisms of intestinal barrier dysfunction. METHODS: Rats were fed 4% with dextran sodium sulfate (DSS) to induce experimental colitis. We analyzed...
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Usefulness of Hyperemic Microvascular Resistance Index as a Predictor of Clinical Outcomes in Patients with ST-Segment Elevation Myocardial Infarction

Jin X, Yoon MH, Seo KW, Tahk SJ, Lim HS, Yang HM, Choi BJ, Choi SY, Hwang GS, Shin JH, Park JS

BACKGROUND AND OBJECTIVES: Microvascular function is a useful predictor of left ventricular functional changes in patients with ST-segment elevation myocardial infarction (STEMI). We evaluated the usefulness of the hyperemic microvascular...
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