- Ceramides and Cell Signaling Molecules in Psoriatic Epidermis: Reduced Levels of Ceramides, PKC-alpha, and JNK
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Lew BL, Cho Y, Kim J, Sim WY, Kim NI
- KMID: 2157790
- J Korean Med Sci.
- 2006 Feb;21(1):95-99.
- doi: 10.3346/jkms.2006.21.1.95
Ceramides are the main lipids in the stratum corneum and are generated during cellular stress and apoptosis by de novo synthesis or by the action of sphingomyelinase. In addition, they... -
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- Wnt5a stimulates chemotactic migration and chemokine production in human neutrophils
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Jung YS, Lee HY, Kim SD, Park JS, Kim JK, Suh PG, Bae YS
- KMID: 2154246
- Exp Mol Med.
- 2013 Jun;45(6):e27.
Wnt5a is a ligand that activates the noncanonical Wnt signaling pathways (beta-catenin-independent pathways). Human neutrophils expressed several Wnt5a receptors, such as Frizzled 2, 5 and 8. Stimulation of human neutrophils... -
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- Phospholipase D inhibitor enhances radiosensitivity of breast cancer cells
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Son JC, Kang DW, Yang KM, Choi KY, Son TG, Min DS
- KMID: 2154257
- Exp Mol Med.
- 2013 Aug;45(8):e38.
Radiation and drug resistance remain the major challenges and causes of mortality in the treatment of locally advanced, recurrent and metastatic breast cancer. Dysregulation of phospholipase D (PLD) has been... -
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- Low energy proton beam induces tumor cell apoptosis through reactive oxygen species and activation of caspases
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Lee KB, Lee JS, Park JW, Huh TL, Lee YM
- KMID: 1103595
- Exp Mol Med.
- 2008 Feb;40(1):118-129.
- doi: 10.3858/emm.2008.40.1.118
Proton beam is useful to target tumor tissue sparing normal cells by allowing precise dose only into tumor cells. However, the cellular and molecular mechanisms by which proton beam induces... -
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- A Study on Altered Expression of Serine Palmitoyltransferase and Ceramidase in Psoriatic Skin Lesion
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Hong KK, Cho HR, Ju WC, Cho Y, Kim NI
- KMID: 1713294
- J Korean Med Sci.
- 2007 Oct;22(5):862-867.
- doi: 10.3346/jkms.2007.22.5.862
Ceramides are the main lipid component maintaining the lamellae structure of stratum corneum, as well as lipid second messengers for the regulation of cellular proliferation and/or apoptosis. In our previous... -
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- Galectin-3 increases the motility of mouse melanoma cells by regulating matrix metalloproteinase-1 expression
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Wang YG, Kim SJ, Baek JH, Lee HW, Jeong SY, Chun KH
- KMID: 1383801
- Exp Mol Med.
- 2012 Jun;44(6):387-393.
Although mounting evidence indicates the involvement of galectin-3 in cancer progression and metastasis, the underlying molecular mechanisms remain largely unknown. In this study, we investigated the effect and possible mechanism... -
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