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Efficacy of Oral Etidronate for Skeletal Diseases in Japan

Iwamoto J, Takeda T, Sato Y

Etidronate is an oral bisphosphonate compound that is known to reduce bone resorption through the inhibition of osteoclastic activity. The efficacy of etidronate for involutional (postmenopausal and senile) and glucocorticoid-induced...
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Prevention and Treatment of Corticosteroid-Induced Osteoporosis

Iwamoto J, Takeda T, Sato Y

Osteoporosis is one of the most serious complications of corticosteroid treatment. Loss of bone mineral density (BMD) and fractures occur early in the course of corticosteroid treatment, and thus early...
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Combined Treatment with Vitamin K2 and Bisphosphonate in Postmenopausal Women with Osteoporosis

Iwamoto J, Takeda T, Ichimura S

  • KMID: 2428340
  • Yonsei Med J.
  • 2003 Oct;44(5):751-756.
Vitamin K2, as well as bisphosphonates, such as etidronate, alendronate, and risedronate, is widely used in the treatment with osteoporosis in Japan. Etidronate increases the lumbar bone mineral density (BMD),...
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Effects of Risedronate on Osteoarthritis of the Knee

Iwamoto J, Takeda T, Sato Y, Matsumoto

The purpose of the present study was to discuss the effects of risedronate on osteoarthritis (OA) of the knee by reviewing the existing literature. The literature was searched with PubMed,...
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Comparison of Effects of Alendronate and Raloxifene on Lumbar Bone Mineral Density, Bone Turnover, and Lipid Metabolism in Elderly Women with Osteoporosis

Iwamoto J, Sato Y, Uzawa M, Takeda T, Matsumoto

  • KMID: 2396095
  • Yonsei Med J.
  • 2008 Feb;49(1):119-128.
PURPOSE: To compare the effects of alendronate and raloxifene on lumbar bone mineral density (BMD), bone turnover, and lipid metabolism in elderly women with osteoporosis. Subjects and Methods: One hundred...
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Relationship between the gut microbiota and bile acid composition in the ileal mucosa of Crohn’s disease

Bamba S, Inatomi O, Nishida A, Ohno M, Imai T, Takahashi K, Naito Y, Iwamoto J, Honda A, Inohara N, Andoh A

Background/Aims: Crosstalk between the gut microbiota and bile acid plays an important role in the pathogenesis of gastrointestinal disorders. We investigated the relationship between microbial structure and bile acid metabolism...
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Differential Effect of Vitamin K and Vitamin D Supplementation on Bone Mass in Young Rats Fed Normal or Low Calcium Diet

Iwamoto J, Takeda T, Ichimura S, Sato Y, Yeh JK

  • KMID: 2428329
  • Yonsei Med J.
  • 2004 Apr;45(2):314-324.
The purpose of this study was to clarify the differential effect of vitamin K and vitamin D supplementation on bone mass in young rats fed a normal or low calcium...
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Effects of Vitamin K2 on the Development of Osteopenia in Rats as the Models of Osteoporosis

Iwamoto J, Takeda T, Sato Y

Vitamin K2 is widely used for the treatment of osteoporosis in Japan. To understand the effects of vitamin K2 on bone mass and bone metabolism, we reviewed its effects on...
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Comparison of Effect of Treatment with Etidronate and Alendronate on Lumbar Bone Mineral Density in Elderly Women with Osteoporosis

Iwamoto J, Takeda T, Sato Y, Uzawa M

  • KMID: 2428289
  • Yonsei Med J.
  • 2005 Dec;46(6):750-758.
The purpose of this open-labeled prospective study was to compare the treatment effects of cyclical etidronate and alendronate on the lumbar bone mineral density (BMD), bone resorption, and back pain...
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Comparison of the Effect of Vitamin K2 and Risedronate on Trabecular Bone in Glucocorticoid-Treated Rats: A Bone Histomorphometry Study

Iwamoto J, Matsumoto , Tadeda T, Sato Y, Yeh JK

  • KMID: 2396058
  • Yonsei Med J.
  • 2009 Apr;50(2):189-194.
PURPOSE: To compare the effect of vitamin K2 and risedronate on trabecular bone in glucocorticoid (GC)-treated rats. MATERIALS AND METHODS: Forty-eight Sprague-Dawley female rats, 3 months of age, were randomized...
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Comparison of the Effects of Alendronate and Alfacalcidol on Hip Bone Mineral Density and Bone Turnover in Japanese Men Having Osteoporosis or Osteopenia with Clinical Risk Factors for Fractures

Iwamoto J, Sato Y, Uzawa M, Takeda T, Matsumoto

PURPOSE: The comparative effects of alendronate and alfacalcidol on bone mineral density (BMD) and bone turnover have already been established in postmenopausal women with osteoporosis. An open-labeled prospective study was...
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Influence of Ovariectomy on Bone Turnover and Trabecular Bone Mass in Mature Cynomolgus Monkeys

Iwamoto J, Seki A, Matsuura M, Sato Y, Takeda T, Matsumoto , Yeh JK

PURPOSE: To examine the influence of ovariectomy (OVX) on bone turnover and trabecular bone mass at the 3 clinically important skeletal sites in mature cynomolgus monkeys. MATERIALS AND METHODS: Six...
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Determinants of One-year Response of Lumbar Bone Mineral Density to Alendronate Treatment in Elderly Japanese Women with Osteoporosis

Iwamoto J, Takeda T, Sato Y, Uzawa M

The purpose of this study was to determine factors that could predict the one-year response of the lumbar bone mineral density (BMD) to alendronate treatment in elderly Japanese women with...
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