- Differentiation characteristics of cholesteatoma epithelium determined by expression of transglutaminase isoenzymes
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Chang CS, Jun BH, Song KY, Kim IG
- KMID: 646044
- J Korean Med Sci.
- 1999 Dec;14(6):665-670.
- doi: 10.3346/jkms.1999.14.6.665
Transglutaminase (TGase) isoenzymes are involved in the process of the differentiation and cornification of keratinocytes in the epidermis. This study investigates the presence and localization of three TGase isoenzymes to... -
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- Decreased nitric oxide synthesis in rats with chronic renal failure
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Kim SW, Lee JU, Paek YW, Kang DG, Choi KC
- KMID: 1730639
- J Korean Med Sci.
- 2000 Aug;15(4):425-430.
- doi: 10.3346/jkms.2000.15.4.425
The present study was aimed at investigating whether an altered role of nitric oxide (NO) is involved in chronic renal failure (CRF). Rats were subjected to 5/6 nephrectomy and kept... -
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- Expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium
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Lee YH, Choi SJ, Kim A, Kim CH, Ji JD, Song GG
- KMID: 1731241
- J Korean Med Sci.
- 2000 Feb;15(1):88-92.
- doi: 10.3346/jkms.2000.15.1.88
The aim of this study was to investigate the expression and localization of cyclooxygenase-1 and -2 (COX-1 and COX-2) in synovial tissues from patients with rheumatoid arthritis (RA). Synovial tissues... -
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- Activation of PKCdelta by tyrosine phosphorylation in rat parotid acinar cells
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Benes C, Zheng Y, Soltoff SP
- KMID: 1026946
- J Korean Med Sci.
- 2000 Aug;15(Suppl):S40-S41.
- doi: 10.3346/jkms.2000.15.S.S40
Receptor- and nonreceptor-mediated stimuli produce increases in both PKCdelta tyrosine phosphorylation and activity in rat parotid acinar cells and other cells. In vivo and in vitro increases and decreases in... -
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- The mechanism of phospholipase C-gamma1 regulation
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Kim MJ, Kim EK, Ryu SH, Suh PG
- KMID: 755072
- Exp Mol Med.
- 2000 Sep;32(3):101-109.
Phospholipase C (PLC)1 hydrolyzes phosphatidylinositol 4,5-bisphosphate to generate the second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces a transient increase in intracellular free Ca2+, while... -
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- Differentially-altered vascular guanylate cyclase isoforms in experimental hypertensive rats
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Lee JU, Kang DG, Kook H, Kim IK, Oh BS
- KMID: 1731311
- J Korean Med Sci.
- 1999 Aug;14(4):386-392.
- doi: 10.3346/jkms.1999.14.4.386
Pathophysiological implications of the vascular nitric oxide (NO)/cGMP pathway were investigated in various rat models of hypertension. The expression of brain and endothelial constitutive NO synthases (bNOS, ecNOS) was determined... -
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- Regulation of matrix metalloproteinase-9 protein expression by 1alpha,25-(OH)2D3 during osteoclast differentiation
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Gu JH, Tong XS, Chen GH, Liu XZ, Bian JC, Yuan Y, Liu ZP
- KMID: 1737619
- J Vet Sci.
- 2014 Mar;15(1):133-140.
- doi: 10.4142/jvs.2014.15.1.133
To investigate 1alpha,25-(OH)2D3 regulation of matrix metalloproteinase-9 (MMP-9) protein expression during osteoclast formation and differentiation, receptor activator of nuclear factor kappaB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) were administered... -
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- An enzymatic method for the detection of human serum albumin
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Javed MU, Waqar SN
- KMID: 1085747
- Exp Mol Med.
- 2001 Jun;33(2):103-105.
Albumin is the most abundant protein in human serum. A dye-binding method is commonly used in clinical laboratories for its estimation using different types of dyes. However, all these dye... -
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- The incidence and histological characteristics of intratubular germ cell neoplasia in postpubertal cryptorchid testis
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Ryang SH, Jung JH, Eom M, Song JM, Chung HC, Chae Y, Lee CM, Kim KJ
- KMID: 2160648
- Korean J Urol.
- 2015 Jul;56(7):515-518.
- doi: 10.4111/kju.2015.56.7.515
PURPOSE: It is well known that testicular germ cell tumors arise with increased frequency in patients with cryptorchidism. In addition, intratubular germ cell neoplasia (ITGCN) is a precursor lesion to... -
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- Pleckstrin homology domain of phospholipase C-gamma1 directly binds to 68-kDa neurofilament light chain
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Kim SK, Choi JH, Suh PG, Chang JS
- KMID: 1094152
- Exp Mol Med.
- 2006 Jun;38(3):265-272.
Phosphoinositide-specific phospholipase C-gamma1 (PLC-gamma1) has two pleckstrin homology (PH) domains: an amino-terminal domain (PH1) and a split PH domain (PH2). Here, we show that overlay assay of bovine brain tubulin... -
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- Altered renal expression of nitric oxide synthase isozymes in spontaneously hypertensive rats
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Kim SW, Moon KH, Lee SC, Kim NH, Kang DG, Lee JU, Choi KC, Kang YJ
- KMID: 759080
- Korean J Intern Med.
- 1999 Jan;14(1):21-26.
OBJECTIVES: The present study was aimed at exploring whether the pathogenesis of hypertension is related with an altered expression of nitric oxide synthase (NOS) isozymes, i.e., bNOS, iNOS... -
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- Infarct Size-limiting Effect of Calcium Preconditioning in Rabbit Hearts
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Kim HD
- KMID: 2157647
- J Korean Med Sci.
- 2003 Jun;18(3):337-343.
- doi: 10.3346/jkms.2003.18.3.337
Recent studies demonstrated that brief period of Ca2+ depletion and repletion (Ca2+ preconditioning, CPC) has strong protective effects against ischemia in a rat heart. CPC and classic preconditioning (IPC) were... -
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- Expression of Osteoprotegerin and RANK Ligand in Breast Cancer Bone Metastasis
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Park HR, Min SK, Cho HD, Kim DH, Shin HS, Park YE
- KMID: 648906
- J Korean Med Sci.
- 2003 Aug;18(4):541-546.
- doi: 10.3346/jkms.2003.18.4.541
Bone destruction is primarily mediated by osteoclastic bone resorption, and cancer cells stimulate the formation and activation of osteoclasts next to metastatic foci. Accumulating evidences indicate that receptor activator of... -
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- Increased levels of multiple forms of dihydrofolate reductase in peripheral blood leucocytes of cancer patients receiving haematopoietic colony-stimulating factors: interim analysis
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Iqbal MP, Burney IA, Sultana F, Mehboobali N, Siddiqui T
- KMID: 1109307
- Exp Mol Med.
- 2000 Jun;32(2):84-87.
The precise mechanism whereby granulocytes proliferate when haematopoietic colony stimulating factors (CSFs) are used in neutropenic cancer patients is poorly understood. The purpose of this study was to investigate whether... -
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- Serologic and histopathologic study of Chlamydia pneumoniae infection in atherosclerosis: a possible pathogenetic mechanism of atherosclerosis induced by Chlamydia pneumoniae
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Song YG, Kwon HM, Kim JM, Hong BK, Kim DS, Huh AJ, Chang KH, Kim HY, Kang TS, Lee BK, Choi DH, Jang YS, Kim HS
- KMID: 711753
- Yonsei Med J.
- 2000 Jun;41(3):319-327.
- doi: 10.3349/ymj.2000.41.3.319
Chronic infection and inflammation have recently been implicated as important etiologic agents for atherosclerosis in general and, in particular, ischemic heart disease. Several agents have been suggested as possible candidates... -
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- Expression of Cyclooxygenase-2 and Its Correlation with Clinicopathologic Factors of Ampulla of Vater Cancer
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Kim HJ, Sohn TS, Lee KT, Lee JK, Paik SW, Rhee JC
- KMID: 2157625
- J Korean Med Sci.
- 2003 Apr;18(2):218-224.
- doi: 10.3346/jkms.2003.18.2.218
There has been no report for the expression of cyclooxygenase-2 (COX-2) and its clinicopathologic and biologic significance in ampulla of Vater cancer. This study was aimed for the clarification of... -
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- Coexpression of cyclooxygenase-2 and matrix metalloproteinases in human aortic atherosclerotic lesions
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Hong BK, Kwon HM, Lee BK, Kim D, Kim IJ, Kang SM, Jang Y, Cho SH, Kim HK, Jang BC, Cho SY, Kim HS, Kim MS, Kwon HC, Lee N
- KMID: 1060276
- Yonsei Med J.
- 2000 Feb;41(1):82-88.
- doi: 10.3349/ymj.2000.41.1.82
Inflammation appears to have a major role in the development of atherosclerosis. Cyclooxygenase-2 (COX-2) is involved in the inflammatory response via the generation of prostanoids that, in turn, are involved... -
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