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Sunitinib-induced hypothyroidism

Kim SW

  • KMID: 2257384
  • Korean J Med.
  • 2009 Jan;76(1):33-36.
Sunitinib malate is a multi-targeted tyrosine kinase inhibitor used for gastrointestinal stromal tumor and renal cell carcinoma. It is also under phase II trial for use in advanced colon cancer,...
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Propylthiouracil, Perchlorate, and Thyroid-Stimulating Hormone Modulate High Concentrations of Iodide Instigated Mitochondrial Superoxide Production in the Thyroids of Metallothionein I/II Knockout Mice

Duan Q, Wang T, Zhang N, Perera V, Liang X, Abeysekera IR, Yao X

BACKGROUND: Increased oxidative stress has been suggested as one of the underlying mechanisms in iodide excess-induced thyroid disease. Metallothioneins (MTs) are regarded as scavengers of reactive oxygen species (ROS) in...
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Thyroid dysfunction during pregnancy

Yim CH

Thyroid dysfunction during pregnancy can result in serious complications for both the mother and infant. However, these complications can be prevented by the optimal treatment of overt maternal thyroid dysfunction....
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Serum Specific IgE to Thyroid Peroxidase Activates Basophils in Aspirin Intolerant Urticaria

Shin YS, Suh DH, Yang EM, Ye YM, Park HS

Thyroid antibodies are frequently observed in urticaria patients, but their roles in urticaria are not clearly elucidated. We investigated the role of serum specific IgE to thyroid peroxidase (TPO) in...
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Autoimmune Thyroid Diseases

Hahm JR

Autoimmune thyroid disease is characterized by the presence of autoantibodies against thyroid peroxidase (TPO), thyroglobulin (Tg), and the thyroid simulating hormone receptor (TSHR). The thyroid gland is a site of...
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Galectin-3 and Thyroid Peroxidase Expression in Thyroid Nodules

Bae GH, Yoon HD, Bae JY, Son HS, Jung ED, Hong SP, Kim MH, Lee SA, Kim HS, Ahn SY

BACKGROUND: The accurate diagnosis of a thyroid nodule is important in deciding a patient's treatment plan and for predicting the prognosis. The histopathological diagnosis of resected specimens are largely positively...
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Association Between Thyroid Associated Ophthalmopath and Thyroid Autoantibody

Hwang DJ, Kim YJ

PURPOSE: The same autoimmune process is thought to cause thyroid associated ophthalmopathy (TAO) and Graves' disease. The aim of this study is to determine hether thyroid autoantibody is related to...
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Prognostic Significance of Thyroid Autoantibodies in Urticaria

Kim JH, Oh TS, Lee SG, Kim IH

  • KMID: 1451718
  • Korean J Dermatol.
  • 2011 Oct;49(10):872-876.
BACKGROUND: The association between chronic urticaria and thyroid autoantibodies is now generally accepted, and some authors recommend screening for thyroid autoimmunity and function in all patients with chronic urticaria for...
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Graves' Disease: Can It Be Cured?

Wiersinga

Whether or not Graves' hyperthyroidism can be really cured, depends on the definition of “cure.” If eradication of thyroid hormone excess suffices for the label “cure,” then all patients can...
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A Case of a False-Positive Anti-Myeloperoxidase Antibody ELISA in a Patient with Hypothyroidism

Jin MK, Seo KY, Kang JY, Choi JY, Yoon SH, Kim YL, Won DI, Park SH

We present a case of a false-positive anti-myeloperoxidase (MPO) antibody result on an ELISA in a patient with anti-thyroid microsomal antibody (TMA)-positive hypothyroidism. A 41-year-old woman presented with dyspnea on...
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Prevalence of autoantibodies in sera from atopic and non-atopic asthmatics

Nahm DH, Kim SS, Lee SK, Park HS

  • KMID: 2285996
  • J Asthma Allergy Clin Immunol.
  • 2000 Apr;20(2):229-235.
BACKGROUND AND OBJECTIVES: There have been several reports showing increased prevalences of various autoantibodies in non-atopic asthma compared to atopic asthma. And the possible involvement of autoimmune mechanisms in the...
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Clinical implications of anti-thyroglobulin antibody measurement before surgery in thyroid cancer

Jo K, Lim DJ

Thyroglobulin antibody (TgAb) is a class G immunoglobulin and a conventional marker for thyroid autoimmunity. From a clinical perspective, TgAb is less useful than thyroid peroxidase antibodies for predicting thyroid...
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Changes in Thyroid Peroxidase and Thyroglobulin Antibodies Might Be Associated with Graves' Disease Relapse after Antithyroid Drug Therapy

Choi YM, Kwak MK, Hong SM, Hong EG

BACKGROUND: Graves' disease (GD) is an autoimmune thyroid disorder caused by antibodies stimulating the thyrotropin (TSH) receptor. TSH receptor antibody (TRAb) measurement is useful for predicting GD relapse after antithyroid...
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Clinical Relevance of Environmental Factors in the Pathogenesis of Autoimmune Thyroid Disease

Wiersinga

Genetic factors contribute for about 70% to 80% and environmental factors for about 20% to 30% to the pathogenesis of autoimmune thyroid disease (AITD). Relatives of AITD patients carry a...
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Prevalence of autoimmune thyroiditis in patients with type 1 diabetes: a long-term follow-up study

Hwang GB, Yoon JS, Park KJ, Lee HS, Hwang JS

PURPOSE: Type 1 diabetes mellitus (DM) is associated with autoimmune diseases such as thyroiditis. Therefore, we aimed to investigate the prevalence of autoimmune thyroiditis in patients with type 1 DM. METHODS:...
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Causal Relationship Between Anti-TPO IgE and Chronic Urticaria by In Vitro and In Vivo Tests

Sánchez J, Sánchez A, Cardona R

PURPOSE: Immunoglobulin (Ig) E autoantibodies against thyroid antigens such as thyroid peroxidase (TPO) have been demonstrated in chronic spontaneous urticaria (CSU) patients in higher frequency than healthy subjects. However, if...
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Review of Molecular Markers for Thyroid Cancer

Han JJ, Hong KS

The incidence of thyroid cancer has been rapidly increased in Korea. Although fine needle aspiration cytology is recommended for diagnosis of cancer, there are some limitations. Patients with indeterminate or...
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Predictors of Lateral Lymph Node Metastasis in Papillary Thyroid Microcarcinoma: A Retrospective Review

Jeong YJ, Mun SH, Bong JG, Park SH

PURPOSE: Cervical lymph node metastasis in patients with papillary thyroid microcarcinoma (PTMC) is associated with an increased recurrence rate and distant metastases. In this study, we analyzed the predictive factors...
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Laboratory Testing in Thyroid Conditions - Pitfalls and Clinical Utility

Soh SB, Aw TC

Thyroid disorders are common, affecting more than 10% of people in the US, and laboratory tests are integral in the management of these conditions. The repertoire of thyroid tests includes...
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Update on Thyroid Hormone Levels and Thyroid Dysfunction in the Korean Population Based on Data from the Korea National Health and Nutrition Examination Survey VI (2013 to 2015)

Chung JH

In 2017, the first Korean nationwide data on serum thyroid stimulating hormone (TSH) levels, serum free thyroxine (fT4) levels, and urinary iodine concentration (UIC) were published based on a population...
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