- Rho-kinase and Insulin Signaling
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Kim YB
- KMID: 2177593
- J Korean Diabetes Assoc.
- 2006 Jul;30(4):237-245.
- doi: 10.4093/jkda.2006.30.4.237
Insulin's ability to acutely stimulate glucose uptake and metabolism in peripheral tissues is essential for normal glucose homeostasis. Resistance to this insulin effect is a major pathogenic feature of type... -
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- The Clinical Application of Insulin-like Growth Factor-I Receptor (IGF-IR) and Insulin Receptor Substrate-1 (IRS-1) Expression in Breast Cancer
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Hong TH, Choi SN, Kim JS, Kim KH, Seo HJ, Kim JI, Ahn CH, Park WC, Oh SJ, Jung SS, Lim KW
- KMID: 2329040
- J Korean Breast Cancer Soc.
- 2003 Dec;6(4):283-290.
PURPOSE: The insulin-like growth factor (IGF) system performs multiple functions in the regulation of breast cancer cell growth. The IGF system is comprised of a complex network of ligands, receptors... -
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- Gly1057Asp Polymorphism of the Insulin Receptor Substrate-2 Genes May Not Have a Significant Impact on Insulin Resistance in Korean Women with Polycystic Ovary Syndrome
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Oh JY, Oh JY, Sung YA, Lee HJ, Chung HW
- KMID: 1468504
- J Korean Endocr Soc.
- 2009 Jun;24(2):100-108.
- doi: 10.3803/jkes.2009.24.2.100
BACKGROUND: Insulin resistance is a key factor in the pathogenesis of polycystic ovary syndrome (PCOS), and several candidate genes involved in insulin action such as insulin receptor or insulin recpetor... -
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- Association of Insulin Receptor Substrate-1 G972R Variant with Non-small Cell Lung Cancer Risk
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Lee CY, Ahn CM, Jeon JH, Kim HJ, Kim SK, Chang J, Kim SK, Chang YS
- KMID: 2319185
- Tuberc Respir Dis.
- 2009 Jul;67(1):8-13.
BACKGROUND: The insulin receptor substrate-1 (IRS-1) is the primary docking molecule for the insulin-like growth factor I receptor (IGF-IR), and is required for activation of the phosphatidylinositol 3'-kinase (PI3K) pathway.... -
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- Telmisartan increases hepatic glucose production via protein kinase C ζ-dependent insulin receptor substrate-1 phosphorylation in HepG2 cells and mouse liver
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Cho KW, Cho DH
- KMID: 2434096
- Yeungnam Univ J Med.
- 2019 Jan;36(1):26-35.
- doi: 10.12701/yujm.2019.00059
BACKGROUND: Dysregulation of hepatic glucose production (HGP) contributes to the development of type 2 diabetes mellitus. Telmisartan, an angiotensin II type 1 receptor blocker (ARB), has various ancillary effects in... -
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- Pear pomace ethanol extract improves insulin resistance through enhancement of insulin signaling pathway without lipid accumulation
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You MK, Kim HJ, Rhyu J, Kim HA
- KMID: 2407767
- Nutr Res Pract.
- 2017 Jun;11(3):198-205.
- doi: 10.4162/nrp.2017.11.3.198
BACKGROUND/OBJECTIVES: The anti-diabetic activity of pear through inhibition of α-glucosidase has been demonstrated. However, little has been reported about the effect of pear on insulin signaling pathway in obesity. The... -
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- Rg3 Improves Mitochondrial Function and the Expression of Key Genes Involved in Mitochondrial Biogenesis in C2C12 Myotubes
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Kim MJ, Koo YD, Kim M, Lim S, Park YJ, Chung SS, Jang HC, Park KS
- KMID: 2354614
- Diabetes Metab J.
- 2016 Oct;40(5):406-413.
- doi: 10.4093/dmj.2016.40.5.406
BACKGROUND: Panax ginseng has glucose-lowering effects, some of which are associated with the improvement in insulin resistance in skeletal muscle. Because mitochondria play a pivotal role in the insulin resistance... -
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- The Effects of Exendin-4 on IRS-2 Expression and Phosphorylation in INS-1 Cells
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Kim JH, Kim JW, Jeon SY, Park HS, Ham DS, You YH, Lee SH, Cho JH, Kang MJ, Lee KW, Kwon HS, Yoon KH, Cha BY, Lee KW, Kang SK, Son HY
- KMID: 2222506
- Korean Diabetes J.
- 2008 Apr;32(2):102-111.
- doi: 10.4093/kdj.2008.32.2.102
BACKGROUND: Insulin receptor substrate 2 (IRS-2) is a key regulator of beta cell proliferation and apoptosis. This study was aimed to investigate effect of the glucolipotoxicity on apoptosis in INS-1... -
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- Hepatic STAMP2 decreases hepatitis B virus X protein-associated metabolic deregulation
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Kim HY, Cho HK, Yoo SK, Cheong J
- KMID: 1506226
- Exp Mol Med.
- 2012 Oct;44(10):622-632.
Six transmembrane protein of prostate 2 (STAMP2) plays a key role in linking inflammatory and diet-derived signals to systemic metabolism. STAMP2 is induced by nutrients/feeding as well as by cytokines... -
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- Simultaneous Translocation of Both TCR Loci (14q11) with Rare Partner Loci (Xq22 and 12p13) in a Case of T-lymphoblastic Leukemia
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Kang DH, Kim SH, Jun JW, Lee YW, Shin HB, Ahn JY, Hong DS, Lee YK, Jeon BR
- KMID: 1381689
- Ann Lab Med.
- 2012 May;32(3):220-224.
- doi: 10.3343/alm.2012.32.3.220
The most common recurrent cytogenetic abnormalities in T-lymphoblastic leukemia (T-acute lymphoblastic leukemia [T-ALL]) involve T-cell receptor (TCR) loci and a variety of partner genes, including HOX11, HOX11L2, MYC, and TAL1.... -
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