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Peripheral Nerve Injury Alters Excitatory and Inhibitory Synaptic Transmission in Rat Spinal Cord Substantia Gelatinosa

Youn DH

  • KMID: 1600055
  • Korean J Physiol Pharmacol.
  • 2005 Jun;9(3):143-147.
Following peripheral nerve injury, excessive nociceptive inputs result in diverse physiological alterations in the spinal cord substantia gelatinosa (SG), lamina II of the dorsal horn. Here, I report the alterations...
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Effects of Modafinil on Behavioral Learning and Hippocampal Synaptic Transmission in Rats

Yan WW, Yao LH, Chen C, Wang HX, Li CH, Huang JN, Xiao P, Liu CY

PURPOSE: Modafinil is a wake-promoting agent that has been proposed to improve cognitive performance at the preclinical and clinical levels. Since there is insufficient evidence for modafinil to be regarded...
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Inhibitory and Excitatory Postsynaptic Currents of Medial Vestibular Nucleus Neurons of Rats

Chun SW, Choi JH, Park BR

  • KMID: 2285272
  • Korean J Physiol Pharmacol.
  • 2003 Apr;7(2):59-64.
The medial vestibular nucleus (MVN) neurons are controlled by excitatory synaptic transmission from the vestibular afferent and commissural projections, and by inhibitory transmission from interneurons. Spontaneous synaptic currents of MVN...
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Vestibular Evoked Myogenic Potential: Recording Methods and Clinical Application

Suh MW, Jeong SH, Kim JS

  • KMID: 1454821
  • J Korean Neurol Assoc.
  • 2010 Feb;28(1):1-12.
Only a few tests can evaluate the function of the saccule and inferior vestibular nerve. Vestibular-evoked myogenic potentials (VEMP) are inhibitory potentials recorded in the contracting muscles, usually in the...
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Isoliquiritigenin, a Chalcone Compound, Enhances Spontaneous Inhibitory Postsynaptic Response

Woo J, Cho S, Lee CJ

Isoliquiritigenin (ILTG) is a chalcone compound and shows various pharmacological properties, including antioxidant and anti-inflammatory activities. In recent study, we have reported a novel role of ILTG in sleep through...
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Roles of Metabotropic Glutamate Receptors in Inhibitory Synaptic Transmission in Rat Medial Vestibular Nucleus Neurons

Park HY

  • KMID: 2195074
  • J Korean Neurol Assoc.
  • 2003 Jun;21(3):273-282.
BACKGROUND: The medial vestibular nucleus (MVN) is involved in the reflex control of the head and eyes, and the recovery of vestibular function after vestibular lesions. This study was performed...
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Comparison of electrophysiological properties of two types of pre-sympathetic neurons intermingled in the hypothalamic paraventricular nucleus

Shen Y, Han SK, Ryu PD

The hypothalamic paraventricular nucleus (PVN) contains two types of neurons projecting to either the rostral ventrolateral medulla (PVN(RVLM)) or the intermediolateral horn (IML) of the spinal cord (PVN(IML)). These two...
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Modulation of Presynaptic GABA Release by Oxidative Stress in Mechanically-isolated Rat Cerebral Cortical Neurons

Hahm ET, Seo JW, Hur J, Cho YW

Reactive oxygen species (ROS), which include hydrogen peroxide (H2O2), the superoxide anion (O2-.), and the hydroxyl radical (OH.), are generated as by-products of oxidative metabolism in cells. The cerebral cortex...
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Actions of Orphan Opioid on the Membrane Conductances and Synaptic Transmission in Rat Medial Vestibular Nucleus Neurons

Park HY, Chang H, Choi JH, Lee MY, Jo KH, Park BR, Chun SW

  • KMID: 2343116
  • J Korean Neurol Assoc.
  • 2004 Dec;22(6):631-637.
BACKGROUND: The medial vestibular nucleus (MVN) is involved in the reflex control of the head and eyes, and the recovery of vestibular function after vestibular injuries. This study was performed...
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Muscarine M2 Receptor-mediated Presynaptic Inhibition of GABAergic Transmission in Rat Meynert Neurons

Jang IS, Akaike N

  • KMID: 1614991
  • Korean J Physiol Pharmacol.
  • 2002 Apr;6(2):63-70.
Cholinergic modulation of GABAergic spontaneous miniature inhibitory postsynaptic currents (mIPSCs) by the activation of muscarine receptors was investigated in mechanically dissociated rat nucleus basalis of the Meynert neurons using the...
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Noradrenergic Modulation of Spontaneous Inhibitory Postsynaptic Currents in the Hypothalamic Paraventricular Nucleus

Lee LH, Chong W, Lee K, Park JB, Ryu PD

  • KMID: 1614992
  • Korean J Physiol Pharmacol.
  • 2002 Apr;6(2):71-80.
Previous studies have suggested that brain stem noradrenergic inputs differentially modulate neurons in the paraventricular nucleus (PVN). Here, we compared the effects of norepinephrine (NE) on spontaneous GABAergic inhibitory postsynaptic...
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Phasic and Tonic Inhibition are Maintained Respectively by CaMKII and PKA in the Rat Visual Cortex

Joo K, Yoon SH, Rhie DJ, Jang HJ

Phasic and tonic gamma-aminobutyric acid(A) (GABA(A)) receptor-mediated inhibition critically regulate neuronal information processing. As these two inhibitory modalities have distinctive features in their receptor composition, subcellular localization of receptors, and...
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Effects of High Concentrations of Naftopidil on Dorsal Root-Evoked Excitatory Synaptic Transmissions in Substantia Gelatinosa Neurons In Vitro

Uta D, Hattori T, Yoshimura

PURPOSE: Naftopidil ((±)-1-[4-(2-methoxyphenyl) piperazinyl]-3-(1-naphthyloxy) propan-2-ol) is prescribed in several Asian countries for lower urinary tract symptoms suggestive of benign prostatic hyperplasia. Previous animal experiments showed that intrathecal injection of naftopidil...
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Layer-specific cholinergic modulation of synaptic transmission in layer 2/3 pyramidal neurons of rat visual cortex

Cho KH, Lee SY, Joo K, Rhie DJ

It is known that top-down associative inputs terminate on distal apical dendrites in layer 1 while bottom-up sensory inputs terminate on perisomatic dendrites of layer 2/3 pyramidal neurons (L2/3 PyNs)...
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The Development of Phasic and Tonic Inhibition in the Rat Visual Cortex

Jang HJ, Cho KH, Park SW, Kim MJ, Yoon SH, Rhie DJ

Gamma-aminobutyric acid (GABA)-ergic inhibition is important in the function of the visual cortex. In a previous study, we reported a developmental increase in GABAA receptor-mediated inhibition in the rat visual...
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Comparison of the GABAergic currents associated with midazolam and propofol in rat hippocampal neurons

Chun SW, Son Y

BACKGROUND: gamma-Aminobutyric acid (GABA), the principal inhibitory neurotransmitter, activates persistent low amplitude tonic currents in several brain regions, in addition to conventional synaptic currents. Tonic conductance is highly sensitive to...
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Roles of Metabotropic Glutamate Receptors 1 and 5 in Rat Medial Vestibular Nucleus Neurons

Lee HI, Lee SH, Chun SW

  • KMID: 2170733
  • Int J Oral Biol.
  • 2011 Jun;36(2):71-78.
Using whole cell current- and voltage-clamp recording we investigated the characteristics and pharmacology of group I metabotropic glutamate receptor (mGluR)-mediated responses in rat medial vestibular nucleus (MVN) neurons. In current...
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Effects of Zinc on Spontaneous Miniature GABA Release in Rat Hippocampal CA3 Pyramidal Neurons

Choi BJ, Jang IS

  • KMID: 2071621
  • Korean J Physiol Pharmacol.
  • 2006 Apr;10(2):59-64.
The effects of Zn2+ on spontaneous glutamate and GABA release were tested in mechanically dissociated rat CA3 pyramidal neurons which retained functional presynaptic nerve terminals. The spontaneous miniature excitatory and...
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Nitric Oxide Modulation of GABAergic Synaptic Transmission in Mechanically Isolated Rat Auditory Cortical Neurons

Lee JJ

The auditory cortex (A1) encodes the acquired significance of sound for the perception and interpretation of sound. Nitric oxide (NO) is a gas molecule with free radical properties that functions...
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