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Immunoradiometric assay of human proinsulin and partially processed proinsulin with use of monoclonal antibody and streptavidin-biotin labeling

Kim JQ, Cho HI, Kim SI, Lee HK, Hales CN

The sensitive and specific immunoradiometric assay is described for human proinsulin and its intermediate peptides (65-66 split and 32-33 split proinsulin). We developed a monoclonal antibody-based two-site immunoradiometric assay with...
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The Evaluation of Domestic Immunoradiometric Assay Kit for Alpha-fetoprotein

Won KS, Ryu JS, Moon DH, Lee HK

  • KMID: 2256936
  • Korean J Nucl Med.
  • 2000 Aug;34(4):353-359.
PURPOSE: Although alpha-fetoprotein is one of the most commonly used tumor markers in Korea, most of the radioimmunoassay kits for alpha-fetoprotein have been imported from foreign countries. The purpose of this study...
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Evaluation of Microparticle Enzyme Immunoassay (MEIA) (ImRx, Abbott) in the Determination of Serum Thyrotropin (TSH)

Hong KS

Microparticle enzyme immunoassay (MEIA) for thyrotropin (TSH) was evaluated and results were compared with those of immunoradiometric assay (IRMA) procedure. Coefficient of variations of within day precision was 3.8-9.6% and...
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Insulin-like growth factor binding protein-3 protease profiles in sera of patients with uterine myoma before and after hysterectomy

Kim JG, Ku SY, Jee BC, Suh CS, Kim SH, Choi YM, Moon SY

  • KMID: 2272477
  • Korean J Obstet Gynecol.
  • 2004 Dec;47(12):2424-2429.
OBJECTIVE: To investigate change in the activity of insulin-like growth factor binding protein-3 (IGFBP-3) protease and change in serum IGFBP-3 levels measurable by western ligand blot and immunoradiometric assay after...
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Significant Issues Derived from the Choice of a PSA Test for Measuring PSA in Serum: Comparison of IMx Enzyme immunoassay and ELSA Immunoradiometric Assay

Ha DB, Kim CI, Jeon DS, Lee SC

  • KMID: 2114936
  • Korean J Urol.
  • 1994 Sep;35(9):955-961.
Prostate specific antigen (PSA) has become established as the most useful serological marker for monitoring patients with prostate cancer. However, the benefits of serum PSA values are controversial in screening...
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Significance of Preoperative Serum CA-125 and TPA Concentrations in Patients with Pelvic Tumors

An GS, Jang KT, Sim JH, Sunwoo JG, Kim MK, Bae DH

  • KMID: 2245045
  • Korean J Gynecol Oncol Colposc.
  • 1997 Jun;8(2):175-182.
We measured serum levels of CA-125 and Tissue polypeptide antigen(TPA) in 135 patients with pelvic tumors(129 benign pelvic tumors and 6 malignant ovarian tumors) preoperatively. Each tumor marker was measured...
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Performance Evaluation of the Serum Thyroglobulin Assays With Immunochemiluminometric Assay and Immunoradiometric Assay for Differentiated Thyroid Cancer

Cho YY, Chun S, Lee SY, Chung JH, Park HD, Kim SW

BACKGROUND: Measurement of postoperative serum thyroglobulin (Tg) is important for detecting persistent or recurrent differentiated thyroid cancer. We evaluated the analytic performance of the DxI 800 assay (Beckman Coulter, USA)...
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Random Assay in Radioimmunoassay: Feasibility and Application Compared with Batch Assay

Lee JM, Lee HH, Park S, Kim TS, Kim SK

PURPOSE: The batch assay has been conventionally used for radioimmunoassay (RIA) because of its technical robustness and practical convenience. However, it has limitations in terms of the relative lag of...
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Effects of Anti-thyroglobulin Antibody on the Measurement of Thyroglobulin: Differences Between Immunoradiometric Assay Kits Available

Ahn BC, Seo JH, Bae JH, Jeong SY, Yoo J, Jung JH, Park HY, Kim JG, Ha SW, Sohn JH, Lee IK, Lee J, Park JS, Kim BW, Lee KB

  • KMID: 2256980
  • Korean J Nucl Med.
  • 2005 Aug;39(4):252-256.
PURPOSE: Thyroglobulin (Tg) is a valuable and sensitive tool as a marker for diagnosis and follow-up for several thyroid disorders, especially, in the follow-up of patients with differentiated thyroid cancer...
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Hyperprolactinemia and Galactorrhea Following Single Epidural Steroid Injection

Won SK, Chun YS, Suk MH, Shim JC

  • KMID: 2104812
  • J Korean Pain Soc.
  • 1998 May;11(1):150-154.
Epidural steroid injection have become one of the most frequently applied conservative option for the management of acute and chronic back pain. As the indications for epidural steroid injections increase so do...
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Influence of Anti-thyroglobulin Antibody on the Measurement of Thyroglobulin using the Immunoradiometric Assay

Ahn BC, Bae JH, Jeong SY, Park HY, Kim JG, Ha SW, Lee J, Kim BW, Lee KB

  • KMID: 2200468
  • J Korean Soc Endocrinol.
  • 2004 Feb;19(1):42-47.
BACKGROUND: Serum thyroglobulin(Tg) is a valuable and sensitive tool needed in the follow-up of patients with differentiated thyroid cancer(DTC), but antithyroglobulin antibody(Anti-Tg), common in patients with DTC, can interfere with...
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Quantitative Measurement of Serum Hepatitis B Surface Antigen Using an Immunoradiometric Assay in Chronic Hepatitis B

Kwon HW, Lee HY, Kim SG, Kim W, Jung YJ, Kang KW, Chung JK, Lee MC, Lee DS

  • KMID: 2051989
  • Nucl Med Mol Imaging.
  • 2011 Mar;45(1):15-20.
PURPOSE: Measurement of serum hepatitis B virus surface antigen (HBsAg) levels is important for the management of chronic hepatitis B patients in terms of monitoring response to antiviral therapy. This...
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Hepatitis B Surface Antigen Quantification across Different Phases of Chronic Hepatitis B Virus Infection Using an Immunoradiometric Assay

Chung KH, Kim W, Kim BG, Lee HY, Jin E, Cho Y, Seo JY, Kim HY, Jung YJ, Kim JW, Jeong JB, Lee KL

BACKGROUND/AIMS: Quantification of hepatitis B surface antigen (HBsAg) is an emerging serologic test and may be useful for identifying treatment strategies for chronic hepatitis B (CHB). This study aimed to...
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The role of serum prostate specific antigen in prostatic cancer and benign prostatic hyperplasia

Kim CS, Ahn TY

  • KMID: 2114905
  • Korean J Urol.
  • 1992 Oct;33(5):806-811.
Serum prostate specific antigen was measured in 26 patients with prostatic cancer, 83 patients with benign prostatic hyperplasia. 12 healthy men without prostate disease and 5 females as normal control...
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CEA and CA19-9 in the Tissue, Portal, and Peripheral Blood of Gastric Cancer Patients

Park BY, Yu W, Chung HY, Bae HI

  • KMID: 2206582
  • J Korean Surg Soc.
  • 1999 Oct;57(4):523-532.
BACKGROUND: To clarify the clinical significance of CEA and CA19-9 in patients with gastric cancer, we evaluated the correlation between tissue expression, the peripheral and the portal levels of these...
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Does 131I Radioactivity Interfere with Thyroglobulin Measurement in Patients Undergoing Radioactive Iodine Therapy with Recombinant Human TSH?

Park S, Bang JI, Lee HY, Kim SE

OBJECTIVES: Recombinant human thyroid-stimulating hormone (rhTSH) is widely used in radioactive iodine therapy (RIT) to avoid side effects caused by hypothyroidism during the therapy. Owing to RIT with rhTSH, serum...
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Alteration of Serum Insulin-like Growth Factor(IGF)-I and IGF-Binding Protein-2 in Healthy Population with Aging

Yoon KC, Lee DY

  • KMID: 2193909
  • J Korean Soc Pediatr Endocrinol.
  • 1998 May;3(1):7-12.
PURPOSE:Insulin-like growth factors, IGF- I and IGF-II, are proteins that promote cellular growth and differentiation of the various organs including the kidney. These peptides circulate in serum bound to...
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Prolactin Response to the Administration of Risperidone and haloperidol in Patients with Schizophrenia and Other Psychotic Disorder

Chung YC, Park KH, Kim DJ, Park KY

  • KMID: 2286939
  • Korean J Psychopharmacol.
  • 2000 Dec;11(4):343-349.
The purposes of this study were to compare the difference of prolactin responses to risperidone and haloperidol, the sex difference in prolactin responses to each drug and the difference of...
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Profile of Insulin, Growth Hormone and Insulin-like Growth Factors in Human Cord Blood According to Birth Weight

Kim HY, Lee DY, Cho SC

  • KMID: 2335376
  • J Korean Pediatr Soc.
  • 1998 Nov;41(11):1484-1490.
PURPOSE: Insulin-like growth factors (IGFs) are mitogenic peptides that are essential for fetal and maternal tissue growth during pregnancy. They circulate primarily with serum IGF-binding protein (IGFBP) which regulates the...
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Radioimmunoassay for Determination of Serum Macrophage Migration Inhibitory Factor

Lee TS, Shin SH, Song JI, Woo KS, Chung WS, Choi CW, Lim SM

  • KMID: 1990854
  • Korean J Nucl Med.
  • 2004 Dec;38(6):532-539.
PURPOSE: There has been a renewal of interest in Macrophage migration inhibitory factor (MIF), especially correlation in pathogenesis of sepsis by many infectious diseases and in regulation of host inflammatory...
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