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Involvement of Protein Kinase C-delta in Vascular Permeability in Acute Lung Injury

Ahn JJ, Jung JP, Park SE, Lee M, Kwon B, Cho HR

Pulmonary edema is a major cause of mortality due to acute lung injury (ALI). The involvement of protein kinase C-delta (PKC-delta) in ALI has been a controversial topic. Here we...
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Anti-proliferative Activity of T-bet

Oh YJ, Shin JH, Won HY, Hwang ES

T-bet is a critical transcription factor that regulates differentiation of Th1 cells from CD4+ precursor cells. Since T-bet directly binds to the promoter of the IFN-gamma gene and activates its...
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Immune-mediated Liver Injury in Hepatitis B Virus Infection

Oh IS, Park SH

Hepatitis B virus (HBV) is responsible for approximately 350 million chronic infections worldwide and is a leading cause of broad-spectrum liver diseases such as hepatitis, cirrhosis and liver cancer. Although...
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Cytomegalovirus Infection and Memory T Cell Inflation

Kim J, Kim AR, Shin EC

Cytomegalovirus (CMV) infection in healthy individuals is usually asymptomatic and results in latent infection. CMV reactivation occasionally occurs in healthy individuals according to their immune status over time. T cell...
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Proteomics in Rheumatoid Arthritis Research

Park YJ, Chung MK, Hwang D, Kim WU

Although rheumatoid arthritis (RA) is the most common chronic inflammatory autoimmune disease, diagnosis of RA is currently based on clinical manifestations, and there is no simple, practical assessment tool in...
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New Insights Into Tissue Macrophages: From Their Origin to the Development of Memory

Italiani P, Boraschi D

Macrophages are the main effector cells of innate immunity and are involved in inflammatory and anti-infective processes. They also have an essential role in maintaining tissue homeostasis, supporting tissue development,...
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