Immune Netw.  2015 Aug;15(4):186-190. 10.4110/in.2015.15.4.186.

Cytomegalovirus Infection and Memory T Cell Inflation

• Kim J
• Kim AR
• Shin EC

• KMID: 2168045
• DOI: http://doi.org/10.4110/in.2015.15.4.186

Abstract

Cytomegalovirus (CMV) infection in healthy individuals is usually asymptomatic and results in latent infection. CMV reactivation occasionally occurs in healthy individuals according to their immune status over time. T cell responses to CMV are restricted to a limited number of immunodominant epitopes, as compared to responses to other chronic or persistent viruses. This response results in progressive, prolonged expansion of CMV-specific CD8+ T cells, termed 'memory inflation'. The expanded CMV-specific CD8+ T cell population is extraordinarily large and is more prominent in the elderly. CMV-specific CD8+ T cells possess rather similar phenotypic and functional features to those of replicative senescent T cells. In this review, we discuss the general features of CMV-specific inflationary memory T cells and the factors involved in memory inflation.

Keyword

Cytomegalovirus; T cells; Senescent T cells; Memory inflation; Immunosenescence

MeSH Terms

Aged
Cytomegalovirus Infections*
Cytomegalovirus*
Humans
Immunodominant Epitopes
Inflation, Economic*
Memory*
T-Lymphocytes
Immunodominant Epitopes

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