- Hydrogen peroxide mediates doxorubicin-induced transglutaminase 2 expression in PC-14 human lung cancer cell line
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Han JA, Park SC
- KMID: 1029936
- Exp Mol Med.
- 1999 Jun;31(2):83-88.
Increased expression of Transglutaminases 2 (TGase 2, TGase C) was observed in PC-14 human lung cancer cells in association with doxorubicin resistance and the reduction of the enzyme expression was correlated with... -
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- Effects of t-butyl hydrogen peroxide on single SR calcium release channels
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Shin JH, Kim KH, Suh CK
- KMID: 711527
- Yonsei Med J.
- 1998 Feb;39(1):56-60.
- doi: 10.3349/ymj.1998.39.1.56
Using lipid bilayer reconstitution technique, we investigated the oxidation effect of t-butyl hydrogen peroxide (tBHP) on the single channel activity of the sarcoplasmic reticulum (SR) calcium release channels isolated from... -
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- Regulation of bcl-2 family in hydrogen peroxide-induced apoptosis in human leukemia HL-60 cells
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Lee JE, Sohn JW, Lee JH, Lee KC, Son CS, Tockgo YC
- KMID: 927133
- Exp Mol Med.
- 2000 Mar;32(1):42-46.
Numerous types of cells have been shown to undergo apoptosis when exposed to oxidant agent such as hydrogen peroxide. In order to understand the functional relationship between the anti- and... -
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- Down syndrome critical region 1 enhances the proteolytic cleavage of calcineurin
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Lee JE, Jang H, Cho EJ, Youn HD
- KMID: 1058021
- Exp Mol Med.
- 2009 Jul;41(7):471-477.
- doi: 10.3858/emm.2009.41.7.052
Down syndrome critical region 1 (DSCR1), an oxidative stress-response gene, interacts with calcineurin and represses its phosphatase activity. Recently it was shown that hydrogen peroxide inactivates calcineurin by proteolytic cleavage.... -
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- The effects of oxygen radicals on the activity of nitric oxide synthase and guanylate cyclase
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Kim SM, Byun JS, Jung YD, Kang IC, Choi SY, Lee KY
- KMID: 755012
- Exp Mol Med.
- 1998 Dec;30(4):221-226.
Reactive oxygen species such as superoxides, hydrogen peroxide (H2O2) and hydroxyl radicals have been suggested to be involved in the catalytic action of nitric oxide synthase (NOS) to produce NO... -
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- Neurotoxicity Screening in a Multipotent Neural Stem Cell Line Established from the Mouse Brain
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Choi YS, Lee MC, Kim HS, Lee KH, Park YG, Kim HK, Jeong HS, Kim MK, Woo YJ, Kim SU, Ryu JK, Choi HB
- KMID: 1778041
- J Korean Med Sci.
- 2010 Mar;25(3):440-448.
- doi: 10.3346/jkms.2010.25.3.440
Neural stem cells (NSCs) have mainly been applied to neurodegeneration in some medically intractable neurologic diseases. In this study, we established a novel NSC line and investigated the cytotoxic responses... -
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- Dual effect of oxidative stress on NF-kappaB activation in HeLa cells
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Byun MS, Jeon KI, Choi JW, Shim JY, Jue DM
- KMID: 755204
- Exp Mol Med.
- 2002 Nov;34(5):332-339.
Reactive oxygen species (ROS) has been implicated as an inducer of NF-kappaB activity in numbers of cell types where exposure of cells to ROS such as H2O2 leads to NF-kappaB... -
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- Expression and Regulation of Latent TGF-beta Binding Protein-1 Transcripts and Their Splice Variants in Human Glomerular Endothelial Cells
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Kwak JH, Woo JS, Shin K, Kim HJ, Jeong HS, Han DC, Kim SI, Park CS
- KMID: 1712745
- J Korean Med Sci.
- 2005 Aug;20(4):628-635.
- doi: 10.3346/jkms.2005.20.4.628
Latent transforming growth factor (TGF)-beta-binding protein (LTBP) is required for the assembly, secretion, matrix association, and activation of latent TGF-beta complex. To elucidate the cell specific expression of the genes... -
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- Stanniocalcin-1 protects bovine intestinal epithelial cells from oxidative stress-induced damage
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Wu LM, Guo R, Hui L, Ye YG, Xiang JM, Wan CY, Zou M, Ma R, Sun XZ, Yang SJ, Guo DZ
- KMID: 2070233
- J Vet Sci.
- 2014 Dec;15(4):475-483.
- doi: 10.4142/jvs.2014.15.4.475
Chronic enteritis can produce an excess of reactive oxygen species resulting in cellular damage. Stanniocalcin-1(STC-1) reportedly possesses anti-oxidative activity, the aim of this study was to define more clearly the... -
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- Regulation of chicken protein tyrosine phosphatase 1 and human protein tyrosine phosphatase 1B activity by casein kinase II- and p56lck-mediated phosphorylation
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Kang KR, Kim CW
- KMID: 927134
- Exp Mol Med.
- 2000 Mar;32(1):47-51.
Protein tyrosine phosphorylation and dephosphorylation are important in the regulation of cell proliferation and signaling cascade. In order to examine whether phosphatase activity of CPTP1 and HPTP1B, typical nontransmembrane protein... -
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- Biliverdin reductase A in the prevention of cellular senescence against oxidative stress
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Kim SY, Kang HT, Choi HR, Park SC
- KMID: 991619
- Exp Mol Med.
- 2011 Jan;43(1):15-23.
- doi: 10.3858/emm.2011.43.1.002
Biliverdin reductase A (BLVRA), an enzyme that converts biliverdin to bilirubin, has recently emerged as a key regulator of the cellular redox cycle. However, the role of BLVRA in the... -
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- Differential expression of two stress-inducible hsp70 genes by various stressors
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Lee JS, Seo JS
- KMID: 1081462
- Exp Mol Med.
- 2002 May;34(2):131-136.
Inducible HSP70s encoded by two almost identical hsp70 genes, known as hsp70.1 and hsp70.3 are located in a tandem array on mouse chromosome 17. Duplication of this gene has been... -
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- A priming role of local estrogen on exogenous estrogen-mediated synaptic plasticity and neuroprotection
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Chamniansawat S, Chongthammakun S
- KMID: 1383803
- Exp Mol Med.
- 2012 Jun;44(6):403-411.
The localization of estrogen (E2) has been clearly shown in hippocampus, called local hippocampal E2. It enhanced neuronal synaptic plasticity and protected neuron form cerebral ischemia, similar to those effects... -
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- Curcumin reduces cold storage-induced damage in human cardiac myoblasts
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Abuarqoub , Green CJ, Foresti R, Motterlini R
- KMID: 1094654
- Exp Mol Med.
- 2007 Apr;39(2):139-148.
Curcumin is a polyphenolic compound possessing interesting anti-inflammatory and antioxidant properties and has the ability to induce the defensive protein heme oxygenase-1 (HO-1). The objective of this study was to... -
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- Phospholipase D is involved in oxidative stress-induced migration of vascular smooth muscle cells via tyrosine phosphorylation and protein kinase C
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Kim J, Min G, Bae YS, Min DS
- KMID: 1380203
- Exp Mol Med.
- 2004 Apr;36(2):103-109.
Oxidative stress has been implicated in mediation of vascular disorders. In the presence of vanadate, H2O2 induced tyrosine phosphorylation of PLD1, protein kinase C-a (PKC-a), and other unidentified proteins in... -
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- Reactive oxygen species regulate the generation of urokinase plasminogen activator in human hepatoma cells via MAPK pathways after treatment with hepatocyte growth factor
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Lee KH, Kim JR
- KMID: 1123465
- Exp Mol Med.
- 2009 Mar;41(3):180-188.
- doi: 10.3858/emm.2009.41.3.021
Tumor cells are known to produce larger amounts of reactive oxygen species (ROS) than normal cells. Although numerous reports have indicated the importance of ROS in urokinase plasminogen activator (uPA)... -
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- Clusterin protects H9c2 cardiomyocytes from oxidative stress-induced apoptosis via Akt/GSK-3beta signaling pathway
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Jun HO, Kim DH, Lee SW, Lee HS, Seo JH, Kim JH, Kim JH, Yu YS, Min BH, Kim KW
- KMID: 991623
- Exp Mol Med.
- 2011 Jan;43(1):53-61.
- doi: 10.3858/emm.2011.43.1.006
Clusterin is a secretory glycoprotein, which is highly up-regulated in a variety of normal and injury tissues undergoing apoptosis including infarct region of the myocardium. Here, we report that clusterin... -
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- Simvastatin inhibits osteoclast differentiation by scavenging reactive oxygen species
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Moon HJ, Kim SE, Yun YP, Hwang YS, Bang JB, Park JH, Kwon IK
- KMID: 1025163
- Exp Mol Med.
- 2011 Nov;43(11):605-612.
- doi: 10.3858/emm.2011.43.11.067
Osteoclasts, together with osteoblasts, control the amount of bone tissue and regulate bone remodeling. Osteoclast differentiation is an important factor related to the pathogenesis of bone-loss related diseases. Reactive oxygen... -
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- Natural compounds, fraxin and chemicals structurally related to fraxin protect cells from oxidative stress
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Whang WK, Park HS, Ham I, Oh M, Namkoong H, Kim HK, Hwang DW, Hur SY, Kim TE, Park YG, Kim JR, Kim JW
- KMID: 1089453
- Exp Mol Med.
- 2005 Oct;37(5):436-446.
Coumarins comprise a group of natural phenolic compounds found in a variety of plant sources. In view of the established low toxicity, relative cheapness, presence in the diet and occurrence... -
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