- CRISPR/Cas9-mediated knockout of Rag-2 causes systemic lymphopenia with hypoplastic lymphoid organs in FVB mice
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Kim JI, Park JS, Kim H, Ryu SK, Kwak J, Kwon E, Yun JW, Nam KT, Lee HW, Kang BC
- KMID: 2459292
- Lab Anim Res.
- 2018 Dec;34(4):166-175.
- doi: 10.5625/lar.2018.34.4.166
Recombination activating gene-2 (RAG-2) plays a crucial role in the development of lymphocytes by mediating recombination of T cell receptors and immunoglobulins, and loss of RAG-2 causes severe combined immunodeficiency... -
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- Recombinant-attenuated Salmonella Pullorum strain expressing the hemagglutinin-neuraminidase protein of Newcastle disease virus (NDV) protects chickens against NDV and Salmonella Pullorum challenge
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Ding K, Shang K, Yu ZH, Yu C, Jia YY, He L, Liao CS, Li J, Zhang CJ, Li YJ, Wu TC, Cheng XC
- KMID: 2407622
- J Vet Sci.
- 2018 Mar;19(2):232-241.
- doi: 10.4142/jvs.2018.19.2.232
Newcastle disease virus (NDV) and Salmonella Pullorum have significant damaging effects on the poultry industry, but no previous vaccine can protect poultry effectively. In this study, a recombinant-attenuated S. Pullorum... -
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- Germline and somatic mutations in homologous recombination genes among Chinese ovarian cancer patients detected using next-generation sequencing
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Zhao Q, Yang J, Li L, Cao D, Yu M, Shen K, the BGI Group
- KMID: 2413427
- J Gynecol Oncol.
- 2017 Jul;28(4):e39.
- doi: 10.3802/jgo.2017.28.e39
OBJECTIVE: To define genetic profiling of homologous recombination (HR) deficiency in Chinese ovarian cancer patients. METHODS: we have applied next-generation sequencing to detect deleterious mutations through all exons in 31 core... -
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- Effects of clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) protein 9 system-Based Deletion of miR-451 in Mouse Embryonic Stem Cells on Their Self-Renewal and Hematopoietic Differentiation
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Kim SJ, Kim CH, An B, Ha KS, Hong SH, Kim KS
- KMID: 2377348
- Tissue Eng Regen Med.
- 2017 Apr;14(2):179-185.
- doi: 10.1007/s13770-017-0031-8
Pluripotent stem cells (PSCs) are a useful source of cells for exploring the role of genes related with early developmental processes and specific diseases due to their ability to differentiate... -
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- Aberrant DNA Double-strand Break Repair Threads in Breast Carcinoma: Orchestrating Genomic Insult Survival
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Kumar A, Purohit S, Sharma NK
- KMID: 2367559
- J Cancer Prev.
- 2016 Dec;21(4):227-234.
- doi: 10.15430/JCP.2016.21.4.227
Breast carcinoma is a heterogeneous disease that has exhibited rapid resistance to treatment in the last decade. Depending genotype and phenotype of breast cancer, there are discernible differences in DNA... -
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- Interactome Analysis Reveals that Heterochromatin Protein 1gamma (HP1gamma) Is Associated with the DNA Damage Response Pathway
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Kim H, Choi JD, Kim BG, Kang HC, Lee JS
- KMID: 2152291
- Cancer Res Treat.
- 2016 Jan;48(1):322-333.
- doi: 10.4143/crt.2014.294
PURPOSE: Heterochromatin protein 1gamma (HP1gamma) interacts with chromosomes by binding to lysine 9-methylated histone H3 or DNA/RNA. HP1gamma is involved in various biological processes. The purpose of this study is... -
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- Expression of pancreatic and duodenal homeobox1 (PDX1) protein in the interior and exterior regions of the intestine, revealed by development and analysis of Pdx1 knockout mice
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Hashimoto , Kamisako T, Kagawa T, Haraguchi , Yagoto M, Takahashi , Kawai K, Suemizu H
- KMID: 2053683
- Lab Anim Res.
- 2015 Jun;31(2):93-98.
- doi: 10.5625/lar.2015.31.2.93
We developed pancreatic and duodenal homeobox1 (Pdx1) knockout mice to improve a compensatory hyperinsulinemia, which was induced by hyperplasia in the beta cells or Langerhans' islands, as the diabetic model... -
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- Depletion of epsilon-COP in the COPI Vesicular Coat Reduces Cleistothecium Production in Aspergillus nidulans
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Kang EH, Song EJ, Kook JH, Lee HH, Jeong BR, Park HM
- KMID: 2312790
- Mycobiology.
- 2015 Mar;43(1):31-36.
- doi: 10.5941/MYCO.2015.43.1.31
We have previously isolated epsilon-COP, the alpha-COP interactor in COPI of Aspergillus nidulans, by yeast two-hybrid screening. To understand the function of epsilon-COP, the aneA+ gene for epsilon-COP/AneA was deleted... -
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- Foldback Intercoil DNA and the Mechanism of DNA Transposition
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Kim BD
- KMID: 2009094
- Genomics Inform.
- 2014 Sep;12(3):80-86.
- doi: 10.5808/GI.2014.12.3.80
Foldback intercoil (FBI) DNA is formed by the folding back at one point of a non-helical parallel track of double-stranded DNA at as sharp as 180degrees and the intertwining of... -
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- Genetics and Biomarkers of Moyamoya Disease: Significance of RNF213 as a Susceptibility Gene
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Fujimura M, Sonobe S, Nishijima , Niizuma K, Sakata H, Kure S, Tominaga T
- KMID: 2223711
- J Stroke.
- 2014 May;16(2):65-72.
Moyamoya disease is characterized by a progressive stenosis at the terminal portion of the internal carotid artery and an abnormal vascular network at the base of the brain. Although its... -
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- Trends and clinical application of induced pluripotent stem cells
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Yoon BS, You S
- KMID: 2190710
- J Korean Med Assoc.
- 2011 May;54(5):502-510.
- doi: 10.5124/jkma.2011.54.5.502
The generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated that adult mammalian cells can be reprogrammed into a pluripotent state by introducing defined transcription factors. iPSCs show... -
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- Ectopic Expression of Ephrin-A5 Under the EphA8 Promoter at the Anterior Region of the Superior Colliculus
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Noh H, Park S
- KMID: 2165319
- Exp Neurobiol.
- 2010 Jun;19(1):49-53.
- doi: 10.5607/en.2010.19.1.49
EphA/ephrin-A mediated signaling has emerged as a key mechanism regulating axon guidance and topographic mapping, particularly in the well-characterized visual system from the retina to the superior colliculus (SC). In... -
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- Effect of combinatorial bone morphogenetic protein 2 and bone morphogenetic protein 7 gene delivery on osteoblastic differentiation
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Bae Y, Kim KH, Kim SH, Lee CW, Koo KT, Kim TI, Seol YJ, Ku Y, Rhyu IC, Chung CP, Lee YM
- KMID: 2321654
- J Korean Acad Periodontol.
- 2009 Aug;39(Suppl):279-286.
PURPOSE: Gene therapy (ex vivo) has recently been used as a means of delivering bone morphogenetic proteins (BMPs) to sites of tissue regeneration. In the present study, we investigated the... -
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- Comparison of Human Sodium/Iodide Symporter (hNIS) Gene Expressions between Lentiviral and Adenoviral Vectors in Rat Mesenchymal Stem Cells
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Park SY, Kim SJ, Lee WW, Lee H, Kim HJ, Chung JK, Kim SE
- KMID: 2051952
- Nucl Med Mol Imaging.
- 2008 Oct;42(5):394-400.
PURPOSE: Quantitative comparison of transgene expression within stem cells between lentivirus and adenovirus-mediated delivery systems has not been reported. Here, we evaluated the human sodium iodide symporter (hNIS) gene expression... -
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- Functional Study of Gene using Inducible Cre System
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Kim JE
- KMID: 1511984
- J Korean Endocr Soc.
- 2006 Oct;21(5):364-369.
- doi: 10.3803/jkes.2006.21.5.364
Gene manipulation by disrupting important genes using homologous recombination in mammals has provided important insights into their function and development with regard to disease. However, many questions related to the... -
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- A case of X-linked agammaglobulinemia with deletion of introns 15-18 of Btk gene mediated by Alu-Alu recombination
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Lee HJ, Ko JS, Kwon SS, Yoo JH, Min JK
- KMID: 2252751
- Korean J Med.
- 2003 Nov;65(Suppl 3):S798-S804.
X-linked agammaglobulinemia (XLA) is characterized by early onset of recurrent bacterial infection, markedly reduced levels of all major classes of immunoglobulins in the serum and few mature B cells in... -
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- Listeria seeligeri Gene Encoding Heme-containing Catalase Produces No Activity in Streptococcus pneumoniae
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Kim HS, Kim IJ
- KMID: 2054956
- J Bacteriol Virol.
- 2002 Dec;32(4):339-346.
Streptococcus pneumoniae is a facultative anaerobe lacking catalase enzyme and requires exogenous catalase supplemented to culture media for aerobic growth. We introduced a catalase gene (kat) of Listeria seeligeri into... -
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- Isolation of Mouse Ig Heavy and Light Chain Genomic DNA Clones, and Construction of Gene Knockout Vector for the Generation of Humanized Xenomouse
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Lee HK, Cha SH
- KMID: 1974523
- Immune Netw.
- 2002 Dec;2(4):233-241.
- doi: 10.4110/in.2002.2.4.233
BACKGROUND: Monoclonal antibodies (mAb) of rodent origin are produced with ease by hybridoma fusion technique, and have been successfully used as therapeutic reagents for humans after humanization by genetic engineering.... -
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- Development of a Mycobacterial Gene Knock-out System using Sequence-specific Recombinase FLP/FRT and its Application to the Construction of a Rhamnose Biosynthetic Gene rmlD Deletion Mutant
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Lee KC, Lee JS, Lee SJ, Lee KH, Lee TJ, Shin HJ, Choi JE, Park HS, Kim SK, Lee TY
- KMID: 1573280
- J Bacteriol Virol.
- 2002 Sep;32(3):221-230.
Development of a new and effecient tuberculosis vaccine is very important since the efficacy of the only available vaccine against tuberculosis, BCG, is variable among races and different ages. Attempts... -
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- Molecular Cloning of Mouse FK-506 Binding Protein 12.6 Gene and Its Biological Function and Expression Patterns in the Various Models of Heart Disease
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Cho MC, Piao H, Youn TJ, Kim DW
- KMID: 2029557
- Korean Circ J.
- 2001 Jul;31(7):711-721.
- doi: 10.4070/kcj.2001.31.7.711
BACKGROUND AND OBJECTIVES: The FK-506 binding protein 12 (FKBP12) regulates intracellular Ca2+ release by stabilizing the Ca2+-induced Ca2+-release channel (ryanodine receptor) in skeletal muscle. It has been recently shown that... -
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