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Hepatic veno-occlusive disease resulting in tacrolimus toxicity after allogeneic hematopoietic stem cell transplantation

Shin SH, Yahng SA, Yoon JH, Lee SE, Cho BS, Kim YJ

Tacrolimus is a widely used immunosuppressive agent for the prophylaxis of graft-versus-host disease in allogeneic hematopoietic stem cell transplantation (HSCT). Since tacrolimus is primarily metabolized by the liver, hepatic dysfunction...
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Hepatic Veno-occlusive Disease after Bone Marrow Transplantation in Leukemic Patients: Two Cases Proven by Laparoscopic Liver Biopsy

Kim BK, Choi H, Kim BW, Choi JH, Park JM, Ju JH, Choi MG, Kim JK, Kang CS, Min WS, Kim CC, Chung KW

  • KMID: 2143306
  • Korean J Hepatol.
  • 1998 Jun;4(2):179-187.
The clinical syndrome of venoocclusive disease of the liver is one of several manifestations of regimen-related toxicity that can occur after high-dose cytoreductive therapy. Hepatic dysfunction after bone marrow transplantation may result from...
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A case of hepatic veno-occlusive disease

Chae HB, Leem JM, Choi JH, Jang LC, Bae IH, Sung RH, Youn SJ

  • KMID: 2306095
  • Korean J Med.
  • 2002 Dec;63(6):711-715.
Veno-occlusive disease of the liver was first reported by Chiari in 1899. Pyrrolizidine-containing substances, chemotherapeutics and hepatic radiation injury can cause this disorder. Bone marrow and renal allograft recipients are...
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Hepatic Veno-occlusive Disease after Combination Chemotherapy with Vincristine, Actinomycin-D, Cyclophosphamide: Successful Treatment with Glutathione and Vitamin E

Lee KH, Bae H, Park HJ

  • KMID: 2037393
  • Korean J Pediatr Hematol Oncol.
  • 2004 Apr;11(1):80-85.
Hepatic veno-occlusive disease (VOD) is characterized by the narrowing or fibrous obliteration of terminal hepatic venules and small sublobular veins. The obliteration of blood flow may lead to tender hepatomegaly,...
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Biomarkers for hepatic sinusoidal obstruction syndrome after hematopoietic cell transplantation

Lee JH

No abstract available.
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Defibrotide Treatment for Hepatic Veno-occlusive Disease after Umbilical Cord Blood Transplantation

Yi JS, Kook H, Noh HY, Baek HJ, Kim SY, Sohn KR, Choi IS, Park HJ, Hwang TJ

  • KMID: 2037395
  • Korean J Pediatr Hematol Oncol.
  • 2004 Apr;11(1):92-96.
Veno-occlusive disease (VOD) of the liver is a life-threatening complication occurring early after blood or bone marrow transplantation (BMT). Effective treatment has not been established in case of severe forms...
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Severe Hepatic Sinusoidal Obstruction Syndrome in a Child Receiving Vincristine, Actinomycin-D, and Cyclophosphamide for Rhabdomyosarcoma: Successful Treatment with Defibrotide

Choi A, Kang YK, Lim S, Kim DH, Lim JS, Lee JA

Hepatic sinusoidal obstruction syndrome (SOS) is a life-threatening syndrome that generally occurs as a complication after hematopoietic stem cell transplantation or, less commonly, after conventional chemotherapy. Regarding SOS in rhabdomyosarcoma...
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A Trial Use of Prophylactic Low-Dose Lipo PGE1 (Eglandin) for the Prevention of Hepatic Veno-Occlusive Disease after Hematopoietic Stem Cell Transplantation in Children with Hematologic Malignancies

Cho B, Sung IK, Kim DW, Lee HJ, Kim SY, Chung NG, Kim CC, Kim HK

  • KMID: 2037436
  • Korean J Pediatr Hematol Oncol.
  • 2000 Oct;7(2):242-248.
PURPOSE: In this study we tested the hypothesis that vasodilatation and antithrombogenic effect in damaged vessels using low-dose Lipo PGE1 might result in increased sinusoidal blood flow and in...
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Hepatic Veno-occlusive Disease after Allogeneic Bone Marrow Transplantation in Patients with Leukemia: Risk Factors and Therapeutic Effect of Recombinant Human Tissue Plasminogen Activator

Lee S

OBJECTIVES: Hepatic veno-occlusive disease(VOD) is a major life-threatening complication of bone marrow transplantation(BMT) caused by high-dose chemotherapy or radiotherapy. The aim of this study is to evaluate the incidence, risk...
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Prophylactic Low-dose Heparin or Prostaglandin E1 may Prevent Severe Veno-occlusive Disease of the Liver after Allogeneic Hematopoietic Stem Cell Transplantation in Korean Children

Song JS, Seo JJ, Moon HN, Ghim T, Im HJ

Studies investigating the effect of prophylactic drugs on hepatic veno-occlusive disease (VOD) development are rare in children that have undergone allogeneic hematopoietic stem cell transplantation (HSCT). This study examined risk...
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Hepatic Veno-occlusive Disease Following Hematopoietic Stem Cell Transplantation in Children: Retrospective Analysis in a Single Institution

Kim SJ, Kook H, Son KR, Baek HJ, Noh HY, Cho YK, Sung JS, Nam HS, Hwang TJ

  • KMID: 2278316
  • Korean J Pediatr Hematol Oncol.
  • 2004 Oct;11(2):205-216.
PURPOSE: Hepatic veno-occlusive disease (VOD) is a life-threatening complication occurring early after stem cell transplantation (SCT). Early diagnosis and effective treatment has not been established in severe VOD. Because there...
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Hepatic Veno-occlusive Disease Developed after Irradiation: A report of three cases

Har K, Kim SH, Park YN, Park C

  • KMID: 2275660
  • Korean J Pathol.
  • 2000 May;34(5):381-385.
Hepatic veno-occlusive disease (VOD) is a rare disease due to occlusion of the terminal hepatic venules and/or sublobular veins, which is a result of endothelial damage from pyrrolizidine alkaloids in...
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Radiation-induced liver disease: current understanding and future perspectives

Kim J, Jung Y

Although radiotherapy (RT) is used for the treatment of cancers, including liver cancer, radiation-induced liver disease (RILD) has emerged as a major limitation of RT. Radiation-induced toxicities in nontumorous liver...
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Hepatic veno-occlusive disease may develop in secondary iron overloaded mice after allogeneic hematopoietic stem cell transplantation with total body irradiation

Yeom MY, Kim YJ, Chung NG, Lee JW, Jang PS, Cho B, Kye CS, Jeong DC

BACKGROUND: The outcome of hematopoietic stem cell transplantation (HSCT) is poor in patients with secondary iron overload (SIO). We evaluated the relationship between SIO and veno-occlusive disease (VOD) in an...
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Quantitative Imaging in Pediatric Hepatobiliary Disease

Yoon H, Shin HJ, Kim MJ, Lee MJ

Pediatric hepatobiliary imaging is important for evaluation of not only congenital or structural disease but also metabolic or diffuse parenchymal disease and tumors. A variety of ultrasonography and magnetic resonance...
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Fludarabine-based myeloablative regimen as pretransplant conditioning therapy in adult acute leukemia/myelodysplastic syndrome: comparison with oral or intravenous busulfan with cyclophosphamide

Lee JH, Choi J, Kwon KA, Lee S, Oh SY, Kwon HC, Kim HJ, Han JY, Kim SH

BACKGROUND: A combination of busulfan (Bu) and cyclophosphamide (Cy) has been used as a standard myeloablative regimen for allogeneic hematopoietic stem cell transplantation (HSCT). Recent studies postulate that fludarabine (Flu)...
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Veno-occlusive disease (VOD) of the liver in Korean patients following allogeneic bone marrow transplantation (BMT): efficacy of recombinant human tissue plasminogen activator (rt-PA) treatment

Lee JH, Lee KH, Choi JS, Zang DY, Kim SB, Kim SW, Suh C, Lee JS, Kim WK, Lee YS, Kim SH

Veno-occlusive disease (VOD) of the liver is a clinical syndrome characterized by hyperbilirubinemia, painful hepatomegaly, and fluid retention. In the bone marrow transplantation (BMT) setting, VOD is caused by dose-intensive...
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Sinusoidal obstruction syndrome after oxaliplatin-based chemotherapy

Seo AN, Kim H

No abstract available.
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Safety and Pharmacokinetics of Intravenous Busulfan as Conditioning prior to Allogeneic Stem Cell Transplantation

Park YH, Lee S, Kim YJ, Lee DG, Park CY, Shin HJ, Kim HJ, Min CK, Kim DW, Lee JW, Min WS, Kim CC

  • KMID: 2083440
  • Korean J Hematol.
  • 2002 May;37(2):127-133.
BACKGROUND: The unpredictable intestinal absorption and bioavailability of oral busulfan (BU) has limited the drug's use in high-dose pretransplant conditioning therapy. To overcome these problems, several trials for the evaluation...
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Hepatic Lesions that Mimic Metastasis on Radiological Imaging during Chemotherapy for Gastrointestinal Malignancy: Recent Updates

You SH, Park BJ, Kim YH

During chemotherapy in patients with gastrointestinal malignancy, the hepatic lesions may occur as chemotherapy-induced lesions or tumor-associated lesions, with exceptions for infectious conditions and other incidentalomas. Focal hepatic lesions arising...
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