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Promoting role of Clonorchis sinensis infection on induction of cholangiocarcinoma during two-step carcinogenesis

Lee JH, Yang HM, Bak UB, Rim HJ

Chronic Clonorchis sinensis (CS) infection is etiologically related to cholangiocarcinoma (CHCA) in human and animals. This study was carried out to clarify the role of CS infection on dimethylnitrosamine (DMN)-induced...
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Age-dependent resistance to Cryptosporidium muris (strain MCR) infection in golden hamsters and mice

Rhee JK, So WS, Kim HC

An age-dependent aspect of resistance to Cryptosporidium muris (strain MCR) infection was monitored in Syrian golden hamsters, Mesocricetus auratus, at 1-, 5- and 10-week of age and in ICR mice....
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Effect of Clonorchis sinensis infection and dimethylnitrosamine administration on the induction of cholangiocarcinoma in Syrian golden hamsters

Lee JH, Rim HJ, Bak UB

The study was carried out to observe the effects of Clonorchis sinensis infection on induction of cholangiocarcinoma in Syrian golden hamsters to which 15 ppm dimethylnitrosamine (DMN) solution was administered...
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Changes in Rena1 Na-K-ATPase Activity and PAH Transport Kinetics in Uninephrectomized Rats and Cold Exposed Hamsters

Park YS, Lee SM, Hwang AR

Renal Na+, K+-activated adenosinetriphosphatase (Na-K-ATPase) activity and the p-aminohippurate (PAH) transport kinetics were studied in uninephrectomized rats and cold exposed hamsters. In rats, the specific activity of renal Na-K-ATPase increased...
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Effect of cholestyramine on the formation of pigment gallstone in high carbohydrate diet-fed hamsters

Lee YC, Song DK, Kim JS, Choi CS

This study was designed to investigate the effect of cholestyramine on the formation of pigment gallstones in high carbohydrate diet-fed hamsters and whether that effect occurred because of cholecystokinin action....
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Smooth Muscle Cells Transplantation is better than Heart Cells Transplantation for Improvement of Heart Function in Dilated Cardiomyopathy

Yoo KJ, Li RK, Weisel RD, Mickle DA, Tomita S, Ohno N, Fujii T

Muscle cell transplantation may delay or prevent cardiac dilation in dilated cardiomyopathy. The present study was designed to compare the effects of the heart function of smooth muscle cell (SMCs)...
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Classification and host specificity of Metagonimus spp. from Korean freshwater fish

Rim HJ, Kim KH, Joo KH

Taxonomic problems of Metagonimus spp. in Korea were investigated. Metacercariae of various freshwater fish species -- Plecoglossus altivelis, Carassius auratus, Zacco platypus, Zacco temmincki, Opsariichthys bidens -- were collected from...
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Karyotypes of Pneumocystis carinii derived from several mammals

Cho SR, Park YG, Moon HN, Lee SH, Hong ST

Pneumocystis carinii is the most important opportunistic pathogen of humans in the world. Pneumocystis carinii is experimentally detected in the lungs of rats, mice, rabbits, and monkeys, however, the...
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Susceptibility of various animals to Pneumocystis carinii infection

Hong ST, Park KH, Lee SH

Pneumocystis carinii (Pc) is an important opportunistic pathogen of immune compromised hosts, and is known to infect various animals. The present study observed the infection status of 6 mammals and...
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Three morphological types of the genus Metagonimus encysted in the dace, Tribolodon taczanowskii, caught from the Sumjin River

Chai JY, Sohn WM, Kim MH, Hong ST, Lee SH

Three morphological types of the genus Metagonimus were found encysted in the dace, Tribolodon taczanowskii, caught from the Sumjin River, Korea. They include Metagonimus Yokogawa type (M. yokogawai), Miyata type,...
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Metagonimus miyatai sp. nov. (Digenea: Heterophyidae), a new intestinal trematode transmitted by freshwater fishes in Japan and Korea

Saito S, Chai JY, Kim KH, Lee SH, Rim HJ

Metagonimus miyatai n. sp. (Digenea: Heterophyidae) is described based on adult flukes collected from experimental dogs and hamsters fed with metacercariae encysted in the sweetfish, Plecoglossus altivelis, dace, tribolodon...
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Development of resistance to reinfection by Clonorchis sinensis in rats

Chung BS, Zhang H, Choi MH, Jeon D, Li S, Lee M, Hong ST

We investigated the induction of resistance to Clonorchis sinensis infection by prior infection in rat and hamster models. Animals were challenged with C. sinensis metacercariae, then treated with praziquantel and...
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Effects of chlorinated aliphatic hydrocarbons on the fidelity of cell division in human CYP2E1 expressing cells

Kim A, Parry EM, Parry JM

  • KMID: 1093602
  • Exp Mol Med.
  • 2002 Mar;34(1):83-89.
Chlorinated organic chemicals are widely used in industry and are present in the environment. Five chlorinated aliphatic hydrocarbons, namely 1-2-dichloroethane, 1,1,2-trichloroethane, trichloroethylene, 2,3-dichlorobutane and 1-chlorohexane were investigated to determine their...
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Proteinase activity in the isolates of Trichomonas vaginalis according to their pathogenicity

Shim YK, Park KH, Chung PR, Im KI

Ten axenic isolates of Trichomonas vaginalis were subcutaneously injected to the BALB/c mice in order to assess their pathogenicity by means of so-called "mouse assay" method. All the isolates revealed...
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In vitro cytotoxicity of Acanthamoeba spp. isolated from contact lens containers in Korea by crystal violet staining and LDH release assay

Shin HJ, Cho MS, Jung SY, Kim HI, Im KI

In order to observe the cytotoxicity of Acanthamoeba spp., which were isolated from contact lens containers as ethiological agents for the probable amoebic keratitis in Korea, the crystal violet staining...
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Cytotoxicity of a cysteine proteinase of adult Clonorchis sinensis

Park H, Ko MY, Paik MK, Soh CT, Seo JH, Im KI

To clarify the correlation of the proteinase activity with pathogenicity of Clonorchis sinensis, the proteinase activity either in excretory-secretory products (ESP) or in crude extracts of adult C. sinensis was...
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Antioxidant activity of extracts from Euryale ferox seed

Lee SE, Ju EM, Kim JH

  • KMID: 1081458
  • Exp Mol Med.
  • 2002 May;34(2):100-106.
Euryale ferox has been widely used in traditional oriental medicine to treat a variety of illness. However, very little is known about the cellular actions by which this plant mediates...
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Nickel (II)-induced apoptosis and G2/M enrichment

Lee SH, Kim DK, Seo YR, Woo KM, Kim CS, Cho MH

  • KMID: 1109301
  • Exp Mol Med.
  • 1998 Sep;30(3):171-176.
Treatment with certain DNA-damaging agents induce a complex cellular response comprising pertubation of cell cycle progression and/or apoptosis on proliferating mammalian cells. Our studies were focused on the cellular effects of nickel (II)...
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Pathogenicity of Korean isolates of Acanthamoeba by observing the experimental infection and zymodemes of five isoenzymes

Im KI, Seo DW, Jeon SH, Kim TE

To determine the pathogenicity of Acanthamoeba spp. isolated in Korea and to develop a isoenzymatic maker, the mortality rate of infected mice, in vitro cytotoxicity against target cells and isoenzyme...
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Cytotoxicity and multinucleate giant cell formation in Chinese hamster lung fibroblast caused by crocidolite and chrysotile

Hong YC, Choi SS

The mechanism of carcinogenic action of asbestos remains unclear but the physical properties of the fiber appear to be important in this process. Asbestos may cause multinucleate giant cell...
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