J Korean Med Sci.  1996 Oct;11(5):397-401. 10.3346/jkms.1996.11.5.397.

Effect of cholestyramine on the formation of pigment gallstone in high carbohydrate diet-fed hamsters

• Lee YC
• Song DK
• Kim JS
• Choi CS

• KMID: 644997
• DOI: http://doi.org/10.3346/jkms.1996.11.5.397

Abstract

This study was designed to investigate the effect of cholestyramine on the formation of pigment gallstones in high carbohydrate diet-fed hamsters and whether that effect occurred because of cholecystokinin action. Forty seven hamsters were divided into three groups: group I(n = 16) was fed on normal rodent chow(43% carbohydrate), group II(n = 14) was fed on a high CHO diet(65% carbohydrate), group III(n = 17) was fed on a high CHO diet containing 4% cholestyramine. Gallstones developed in 0% of group I, 42.9% of group II and 5.9% of group III(P< 0.05, group II vs III). To evaluate the chronic status of cholecystokinin level, the wet weight of pancreas and the average area of pancreatic acinar in microscopic high power field were measured. There was no significant difference between group II and group III in pancreatic weight and average area of pancreatic acinar(P> 0.05). In gallbladder bile analysis, there was also no significant difference between group II and group III in cholesterol, phospholipid, total calcium, total bilirubin and bile acid levels. In conclusion, cholestyramine decreases the frequency of pigment gallstone formation in high CHO diet-fed hamsters, but it is not clear whether the mechanism of cholestyramine decreasing the gallstone formation is due to the action of cholecystokinin.

Keyword

Cholestyramine; Pigment gallstone; Hamster

MeSH Terms

Animal
Bilirubin/metabolism
Cholecystokinin/*analysis
Cholelithiasis/*pathology
Cholesterol/metabolism
Cholestyramine/*administration & dosage
Dietary Carbohydrates/*administration & dosage
Female
Gallbladder/*metabolism/pathology
Hamsters
Male
Mesocricetus
Organ Weight
Pancreas/physiopathology
Phospholipids/metabolism
Pigmentation
Support, Non-U.S. Gov't