- Loss of Human Leukocyte Antigen Class I Expression Is Associated with Poor Prognosis in Patients with Advanced Breast Cancer
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Park HS, Cho U, Im SY, Yoo CY, Jung JH, Suh YJ, Choi HJ
- KMID: 2465446
- J Pathol Transl Med.
- 2019 Mar;53(2):75-85.
- doi: 10.4132/jptm.2018.10.11
BACKGROUND: Human leukocyte antigen class I (HLA-I) molecules play important roles in regulating immune responses. Loss or reduction of HLA-I expression has been shown to be associated with prognosis in... -
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- Expression of Immunoproteasome Subunit LMP7 in Breast Cancer and Its Association with Immune-Related Markers
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Lee M, Song IH, Heo SH, Kim YA, Park IA, Bang WS, Park HS, Gong G, Lee HJ
- KMID: 2437601
- Cancer Res Treat.
- 2019 Jan;51(1):80-89.
- doi: 10.4143/crt.2017.500
PURPOSE: In the presence of interferon, proteasome subunits are replaced by their inducible counterparts to form an immunoproteasome (IP) plays a key role in generation of antigenic peptides presented by... -
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- Donor Specific Antibody Negative Antibody-Mediated Rejection after ABO Incompatible Liver Transplantation
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Lee B, Ahn S, Kim H, Han HS, Yoon YS, Cho JY, Choi YR
- KMID: 2430591
- J Korean Soc Transplant.
- 2018 Dec;32(4):108-112.
- doi: 10.4285/jkstn.2018.32.4.108
Antibody-mediated rejection (AMR) is a major complication after ABO-incompatible liver transplantation. According to the 2016 Banff Working Group on Liver Allograft Criteria for the diagnosis of acute AMR, a positive... -
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- Genetic markers of severe cutaneous adverse reactions
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Jung JW, Kim JY, Park IW, Choi BW, Kang HR
- KMID: 2419997
- Korean J Intern Med.
- 2018 Sep;33(5):867-875.
- doi: 10.3904/kjim.2018.126
Adverse drug reactions can cause considerable discomfort. They can be life-threatening in severe cases, requiring or prolonging hospitalization, impeding proper treatment, and increasing treatment costs considerably. Although the incidence of... -
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- Characteristics and Clinical Significance of de novo Donor-Specific Anti-HLA Antibodies after Kidney Transplantation
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Jung HY, Kim SH, Seo MY, Cho SY, Yang Y, Choi JY, Cho JH, Park SH, Kim YL, Kim HK, Huh S, Won DI, Kim CD
- KMID: 2418615
- J Korean Med Sci.
- 2018 Aug;33(34):e217.
- doi: 10.3346/jkms.2018.33.e217
BACKGROUND: The association of de novo donor-specific anti-human leukocyte antigens (HLA) antibodies (DSA) and development of antibody-mediated rejection (AMR) in kidney transplant recipients (KTRs) is still undetermined. METHODS: We prospectively screened... -
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- HLA-C*17, DQB1*03:01, DQA1*01:03 and DQA1*05:05 Alleles Associated to Bullous Pemphigoid in Brazilian Population
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Chagury AA, Sennes LU, Gil JM, Kalil J, Rodrigues , Rosales CB, Miziara ID
- KMID: 2399748
- Ann Dermatol.
- 2018 Feb;30(1):8-12.
- doi: 10.5021/ad.2018.30.1.8
BACKGROUND: Bullous pemphigoid (BP) is an autoimmune disease with bullous vesicles and an incidence of 0.2 to 1.4 per 100,000 inhabitants. Many studies have been published demonstrating the association of... -
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- MergeReference: A Tool for Merging Reference Panels for HLA Imputation
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Cook S, Han B
- KMID: 2394767
- Genomics Inform.
- 2017 Sep;15(3):108-111.
- doi: 10.5808/GI.2017.15.3.108
Recently developed computational methods allow the imputation of human leukocyte antigen (HLA) genes using intergenic single nucleotide polymorphism markers. To improve the imputation accuracy in HLA imputation, it is essential... -
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- Immunologic properties of differentiated and undifferentiated mesenchymal stem cells derived from umbilical cord blood
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Lee HJ, Kang KS, Kang SY, Kim HS, Park SJ, Lee SY, Kim KD, Lee HC, Park JK, Paik WY, Lee L, Yeon SC
- KMID: 2413127
- J Vet Sci.
- 2016 Sep;17(3):289-297.
- doi: 10.4142/jvs.2016.17.3.289
The expression of immunogenic markers after differentiation of umbilical cord blood (UCB)-derived mesenchymal stem cells (MSC) has been poorly investigated and requires extensive in vitro and in vivo testing for... -
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- T-cell-mediated drug hypersensitivity: immune mechanisms and their clinical relevance
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Yun J, Cai F, Lee FJ, Pichler WJ
- KMID: 2396975
- Asia Pac Allergy.
- 2016 Apr;6(2):77-89.
- doi: 10.5415/apallergy.2016.6.2.77
T-cell-mediated drug hypersensitivity represents a significant proportion of immune mediated drug hypersensitivity reactions. In the recent years, there has been an increase in understanding the immune mechanisms behind T-cell-mediated drug... -
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- Association of HLA Genotype and Fulminant Type 1 Diabetes in Koreans
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Kwak SH, Kim YJ, Chae J, Lee CH, Han B, Kim JI, Jung HS, Cho YM, Park KS
- KMID: 2166527
- Genomics Inform.
- 2015 Dec;13(4):126-131.
- doi: 10.5808/GI.2015.13.4.126
Fulminant type 1 diabetes (T1DM) is a distinct subtype of T1DM that is characterized by rapid onset hyperglycemia, ketoacidosis, absolute insulin deficiency, and near normal levels of glycated hemoglobin at... -
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- Allele and Haplotype Frequencies of Human Leukocyte Antigen-A, -B, -C, -DRB1, and -DQB1 From Sequence-Based DNA Typing Data in Koreans
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In JW, Roh EY, Oh S, Shin S, Park KU, Song EY
- KMID: 2045866
- Ann Lab Med.
- 2015 Jul;35(4):429-435.
- doi: 10.3343/alm.2015.35.4.429
BACKGROUND: Data on allele frequencies (AFs) and haplotype frequencies (HFs) of HLA-C and -DQB1 are limited in Koreans. We investigated AFs and HFs of HLA-A, -B, -C, -DRB1, and -DQB1... -
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- Interlaboratory Comparison of the Results of Lifecodes LSA Class I and Class II Single Antigen Kits for Human Leukocyte Antigen Antibody Detection
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Oh EJ, Park H, Park KU, Kang ES, Kim HS, Song EY
- KMID: 2363204
- Ann Lab Med.
- 2015 May;35(3):321-328.
- doi: 10.3343/alm.2015.35.3.321
BACKGROUND: Although single antigen bead assays (SAB) are approved qualitative tests, the median fluorescence intensity (MFI) values obtained from SAB are frequently used in combination with quantitative significances for diagnostic... -
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- Investigation of Serum Angiotensin II Type 1 Receptor Antibodies at the Time of Renal Allograft Rejection
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Lee H, Kim JI, Moon IS, Chung BH, Yang CW, Kim Y, Han K, Oh EJ
- KMID: 2363203
- Ann Lab Med.
- 2015 May;35(3):314-320.
- doi: 10.3343/alm.2015.35.3.214
BACKGROUND: Angiotensin II type 1 receptor (AT1R) is responsible for cardiovascular effects mediated by angiotensin II. This study aimed to investigate the impact of antibodies directed against AT1R (anti-AT1R) in... -
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- The Impact of HLA and KIR Ligand Mismatching on Unrelated Allogeneic Hematopoietic Stem Cell Transplantation in Korean Adult Patients
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Park H, Rho EY, In JW, Kim I, Yoon SS, Park S, Shin S, Park KU, Song EY
- KMID: 2363157
- Ann Lab Med.
- 2015 Jan;35(1):111-117.
- doi: 10.3343/alm.2015.35.1.111
BACKGROUND: The impact of HLA and KIR ligand mismatching on the outcome of hematopoietic stem cell transplantation (HSCT) remains unclear. Previous reports have identified considerable ethnic differences in the impact... -
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- Severe Cutaneous Adverse Reaction
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Yang MS, Jung JW, Kang HR
- KMID: 2269361
- Korean J Med.
- 2014 Dec;87(6):665-674.
- doi: 10.3904/kjm.2014.87.6.665
Severe adverse cutaneous reactions (SCARs) include Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS). Although recent advances in pharmacogenomics have revealed the association... -
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- Current Status of Heart Transplantation and Left Ventricular Assist Device: Major Changes in the Last Decade
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Lee SJ, Hong SG
- KMID: 2168351
- Hanyang Med Rev.
- 2014 Nov;34(4):185-196.
- doi: 10.7599/hmr.2014.34.4.185
Heart transplantation is the last treatment option in refractory end stage heart failure, which can prolong survival. The number of heart transplantations has increased and the survival rate has improved... -
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- Resolution of Ambiguous HLA Genotyping in Korean by Multi-Group-Specific Sequence-Based Typing
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Park Y, Yoon CE, Kwon OJ, Kim YS, Kim HS
- KMID: 2130827
- Yonsei Med J.
- 2014 Jul;55(4):1005-1013.
- doi: 10.3349/ymj.2014.55.4.1005
PURPOSE: To evaluate a multi-group-specific sequence-based typing (SBT) method for resolving ambiguous results from human leukocyte antigen (HLA) genotyping. MATERIALS AND METHODS: A total of 50 samples that showed ambiguous genotypes... -
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- Type 1 diabetes genetic susceptibility markers and their functional implications
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Park Y
- KMID: 1737956
- J Genet Med.
- 2014 Jun;11(1):1-10.
- doi: 10.5734/JGM.2014.11.1.1
Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by selective destruction of pancreatic beta-cells resulting in insulin deficiency. The genetic determinants of T1D susceptibility have been linked to... -
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- Use of Bortezomib as Anti-Humoral Therapy in Kidney Transplantation
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Yang KS, Jeon H, Park Y, Jo IH, Kim JI, Moon IS, Choi BS, Park CW, Yang CW, Kim YS, Chung BH
- KMID: 1786104
- J Korean Med Sci.
- 2014 May;29(5):648-651.
- doi: 10.3346/jkms.2014.29.5.648
This study aimed to investigate the effect of bortezomib in the desensitization and treatment of acute antibody mediated rejection (AAMR) in kidney transplantation. Nine patients who received bortezomib therapy for... -
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- Stevens-Johnson syndrome / toxic epidermal necrolysis: an Asia-Pacific perspective
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Thong BY
- KMID: 2397298
- Asia Pac Allergy.
- 2013 Oct;3(4):215-223.
- doi: 10.5415/apallergy.2013.3.4.215
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse reactions (SCAR) to drugs which are associated with significant morbidity and mortality. High risk drugs in Asia are... -
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