Yonsei Med J.  1988 Sep;29(3):259-262. 10.3349/ymj.1988.29.3.259.

A Study of HLA Antigens in Behcet's Syndrome

• Lee S
• Koh YJ
• Kim DH
• Bang D
• Nam IW
• Lee KH
• Park K

• KMID: 1729556
• DOI: http://doi.org/10.3349/ymj.1988.29.3.259

Abstract

Fifty-two Korean patients with Behcet's syndome were typed for HLA antigens. 52 apparently healthy Korean subjects were used as controls; 42 for HLA-A, B, C and all 52 for HLA-DR typing. HLA-B5 and DRw8 presented significantly high frequencies in all patiens. According to Shimizu's classification, HLA-B5 and DRw8 were significantly increased in the complete type; B5 in the incomplete type; DR3 in the suspected-possible type. According to Lehner's classification, HLA-DR3 was significantly increased in the neurological type; B5 in the ocular type; B5 in the ocular type. We confirmed the association of HLA-B5 with the severity of Beh et's syndrome. A relation might exist between DRw8, DR3 and Behcet's syndrome.

Keyword

Behcet's syndrome; HLA typing

MeSH Terms

Adolescent
Adult
Behcet Syndrome/*immunology
Female
HLA Antigens/*analysis/classification
Human
Korea
Male
Middle Age
Support, Non-U.S. Gov't