- The possibility of low isomerization of β-lapachone in the human body
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Lee KM, Gwon MR, Lee HW, Seong SJ, Yoon YR
- KMID: 2525615
- Transl Clin Pharmacol.
- 2021 Sep;29(3):160-170.
- doi: 10.12793/tcp.2021.29.e16
β-Lapachone has been reported to have anticancer and various other therapeutic effects, but is limited in clinical applications by its low bioavailability. pH-Dependent isomerization can be suggested as one plausible... -
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- Development and validation of a UPLC-MS/MS method for the quantification of acetaminophen in human plasma and its application to pharmacokinetic studies
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Cha J, Kim BK, Gwon MR, Lee J, Ohk B, Kang WY, Lim MS, Seong SJ, Kim HJ, Lee HW, Yoon YR
- KMID: 2383597
- Transl Clin Pharmacol.
- 2016 Mar;24(1):30-36.
- doi: 10.12793/tcp.2016.24.1.30
We developed an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the determination of acetaminophen concentration in human plasma. Following protein precipitated extraction, the analytes were separated and analyzed using... -
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- Pharmacokinetics and bioequivalence of fixed-dose combination of candesartan cilexetil/amlodipine besylate (16/10 mg) versus coadministration of individual formulations in healthy subjects
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Lee HW, Kang WY, Jung W, Gwon MR, Yang DH, Kim EH, Cho K, Yoon YR, Seong SJ
- KMID: 2505155
- Transl Clin Pharmacol.
- 2020 Jun;28(2):92-101.
- doi: 10.12793/tcp.2020.28.e8
This study compared the pharmacokinetics of a fixed-dose combination (FDC) of candesartan (16 mg) and amlodipine (10 mg) versus coadministration of individual formulations to clarify the bioequivalence of the FDC.... -
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- Metabolomic analysis of healthy human urine following administration of glimepiride using a liquid chromatography-tandem mass spectrometry
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Do EY, Gwon MR, Kim BK, Ohk B, Lee HW, Kang WY, Seong SJ, Kim HJ, Yoon YR
- KMID: 2386763
- Transl Clin Pharmacol.
- 2017 Jun;25(2):67-73.
- doi: 10.12793/tcp.2017.25.2.67
Glimepiride, a third generation sulfonylurea, is an antihyperglycemic agent widely used to treat type 2 diabetes mellitus. In this study, an untargeted urinary metabolomic analysis was performed to identify endogenous... -
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- Determination of sumatriptan in human plasma using liquid chromatography-mass spectrometry for pharmacokinetic study in healthy Korean volunteers
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Cho S, Jegal M, Ohk B, Kim BK, Gwon MR, Kang WY, Seong SJ, Kim HJ, Lee HW, Yoon YR
- KMID: 2386768
- Transl Clin Pharmacol.
- 2017 Jun;25(2):106-111.
- doi: 10.12793/tcp.2017.25.2.106
This study describes the development of an analytical method to determine sumatriptan levels in human plasma using high performance liquid chromatography (HPLC) coupled with triple quadrupole tandem mass spectrometry (MS/MS)... -
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- A randomized, open-label, single-dose, two-way crossover study to assess the pharmacokinetics between two tablets of fixed-dose combination formulation with raloxifene and cholecalciferol and concomitant administration of each agents in healthy male volunteers
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Lee HW, Kang WY, Gwon MR, Choi EJ, Kim EH, Cho K, Lee B, Seong SJ, Yoon YR
- KMID: 2538875
- Transl Clin Pharmacol.
- 2022 Sep;30(3):136-144.
- doi: 10.12793/tcp.2022.30.e13
A new fixed-dose combination (FDC) formulation of raloxifene 60 mg and cholecalciferol 800 IU was developed to improve the medication compliance and overall efficacy of raloxifene treatment in postmenopausal osteoporosis... -
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- Population pharmacokinetic analysis of the multiple peaks phenomenon in sumatriptan
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Lee J, Lim MS, Seong SJ, Park SM, Gwon MR, Han S, Lee SM, Kim W, Yoon YR, Yoo HD
- KMID: 2351811
- Transl Clin Pharmacol.
- 2015 Dec;23(2):66-74.
- doi: 10.12793/tcp.2015.23.2.66
The objective of this study was to develop a population pharmacokinetic (PK) model for sumatriptan, which frequently shows an atypical absorption profile with multiple peaks. Sumatriptan, a selective agonist for... -
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- Steady-State Pharmacokinetic Properties of Tamsulosin in Healthy Male Volunteers
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Seong SJ, Lee HW, Lee J, Lim MS, Kim EH, Park SM, Gwon MR, Yoon YR
- KMID: 2203226
- J Korean Soc Clin Pharmacol Ther.
- 2013 Dec;21(2):130-140.
- doi: 10.12793/jkscpt.2013.21.2.130
BACKGROUND: To evaluate the pharmacokinetic properties of daily oral doses of tamsulosin administered to fasted healthy Korean male volunteers for 5 days. METHODS: In a randomized, open-label, multiple-dose, two-period, crossover study,... -
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- Metabolic Profiling of Plasma from Pancreatic Cancer Patients in Korea
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Gwon MR, Yoon YR, Seol YM, Choi YJ, Kim DU, Choe S, Lee SH, Hwang SY, Kim H
- KMID: 2448662
- Korean J Pancreas Biliary Tract.
- 2019 Apr;24(2):61-67.
- doi: 10.15279/kpba.2019.24.2.61
BACKGROUND/AIMS: Pancreatic cancer (PC) patients have poor prognoses because this cancer is typically diagnosed at an advanced stage and the therapeutic options are limited. We examined the potential of metabolic... -
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