- Major concerns regarding lung injury and related health conditions caused by the use of humidifier disinfectant
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Park D
- KMID: 2469670
- Environ Health Toxicol.
- 2016 ;31(1):e2016014.
- doi: 10.5620/eht.e2016014
A total of 221 patients were evaluated to be humidifier disinfectant associated with lung injury (HDLI) through two rounds of programs through April 2015. The humidifier disinfectant (HD) brands most... -
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- An analysis of a humidifier disinfectant case from a toxicological perspective
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Park K
- KMID: 2469669
- Environ Health Toxicol.
- 2016 ;31(1):e2016013.
- doi: 10.5620/eht.e2016013
An analysis of patients and fatalities due to exposure to polyhexamethylene guanidine (PHMG) shows that PHMG causes mainly lung diseases such as pulmonary fibrosis. However, no research on the other... -
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- A review of current studies on cellular and molecular mechanisms underlying pulmonary fibrosis induced by chemicals
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Kim HR, Shin DY, Chung KH
- KMID: 2434039
- Environ Health Toxicol.
- 2018 Sep;33(3):e2018014.
- doi: 10.5620/eht.e2018014
Several studies showed that the inflammatory and fibrotic responses induced by polyhexamethylene guanidine phosphate (PHMG-p) were similar to those observed for idiopathic pulmonary fibrosis in South Korea in 2011. “Omicâ€... -
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- Eye irritation tests of polyhexamethylene guanidine phosphate (PHMG) and chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) using a tissue model of reconstructed human cornea-like epithelium
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Park J, Lee H, Park K
- KMID: 2470816
- Environ Health Toxicol.
- 2019 Jun;34(2):e2019004.
- doi: 10.5620/eht.e2019004
Disinfectants including polyhexamethylene guanidine phosphate (PHMG) and mixtures of chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) have been widely used in Korea to prevent microbial growth in the humidifier water, which triggered an outbreak of... -
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- Mass Production and Characterization of Anti-HBsAg Human Antibody B7 Fd
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Choi IH, Kim IJ, Chung JH, Choi SJ, Im JB, Yi KS, Suh PG, Ryu SH
- KMID: 2146908
- J Korean Soc Microbiol.
- 1999 Jun;34(3):265-275.
We expressed anti-HBsAg human antibody fragment (B7 Fd) using pRSET-A vector and BL21(DE3)pLysS strain of E. coli. B7 Fd is composed only of variable domain (VH) and CH1 constant domain... -
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- Isolation and Quantification of Glycosaminoglycans from Human Hair Shaft
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Maniatopoulou E, Bonovas S, Sitaras N
- KMID: 2382875
- Ann Dermatol.
- 2016 Oct;28(5):533-539.
- doi: 10.5021/ad.2016.28.5.533
BACKGROUND: There is evidence that glycosaminoglycans (GAGs) are present in the hair shaft within the follicle but there are no studies regarding GAGs isolation and measurement in the human hair... -
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- Unfolded Histidine-Tagged Protein is Immobilized to Nitrilotriacetic Acid-Nickel Beads, But Not the Nickel-Coated Glass Slide
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Cho M, Ahn S, Park H
- KMID: 1512149
- Genomics Inform.
- 2006 Sep;4(3):133-136.
The adsorption of proteins on the surface of glass slides is essential for construction of protein chips. Previously, we prepared a nickel-coated plate by the spin-coating method for immobilization of... -
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- Changes of Type IV Collagen and Laminin of Glomeruli in Vacor-induced Diabetic Rat
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Park SS, Kim JM, Lee TH, Lee KY
- KMID: 2172470
- Chonnam Med J.
- 1999 Sep;35(3):323-332.
Vacor-administrated rats showed the thickening of the glomerular basement membrane (GBM). To investigate how the glomerulopathy occurs, the amounts of total and guanidine HCl soluble-type IV collagen and laminin in... -
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- A Case of Insulin: dependent Diabetes Mellitus Carrying the 3243 bp tRNALUR(UUR)-- Point Mutation of Mitochondrial DNA
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Park HW, Kim WH, Kim HJ, Kim WB, Kim SK, Shin CS, Lee HK, Cheong HI
- KMID: 2080556
- Korean J Med.
- 1997 Jul;53(1):133-139.
We describe a case of insulin-dependent diabetes mellitus(lDDM) with a mutation at nucleotide 3243 of mitochondrial DNA. A 24-years-old female presented with recurrent episodes of generalised tonic clonic seizures, cognitive... -
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- Discrimination of Hantaviruses from the Tissues of Infected Hamsters to 5 Different Serotype Hantaviruses by Nested RT-PCR using Hantavirus Serotype Specific Primers
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Chu YK, Lee HW
- KMID: 2204565
- J Korean Soc Virol.
- 1997 Mar;27(1):49-57.
We developed a sensitive, nested reverse transcription-polymerase chain reaction (RT-PCR) to detect Hantaan, Seoul, Belgrade, Puumala and Sin Nombre viruses in animal tissues. Total RNA was extracted from blood, lung... -
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- Association between use of humidifier disinfectant and allergic rhinitis in Korean children: a cross-sectional study based on the eighth Panel Study on Korean Children (PSKC)
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Koh TH, Park JT, Kwon D, Kwak K
- KMID: 2471277
- Ann Occup Environ Med.
- 2020 ;32(1):e9.
- doi: 10.35371/aoem.2020.32.e9
BACKGROUND: Rhinitis was the most frequently diagnosed disorder among users of humidifier disinfectants (HDs). The aim of our study was to investigate on the relationship between allergic rhinitis (AR) and... -
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- Humidifier disinfectant lung injury, how do we approach the issues?
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Choi JE, Hong SB, Do KH, Kim HJ, Chung S, Lee E, Choi J, Hong SJ
- KMID: 2469675
- Environ Health Toxicol.
- 2016 ;31(1):e2016019.
- doi: 10.5620/eht.e2016019
A large portion of the Korean population has been exposed to toxic humidifier disinfectants (HDs), and considering that the majority of the victims are infants, the magnitude of the damage... -
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- Experimental Study On The Bone Induction Capacity Of The Porcine Bone Matrix-Derived Bone Morphogenetic Protein
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Park YW, Lee JH, Kim SK
- KMID: 1960895
- J Korean Assoc Maxillofac Plast Reconstr Surg.
- 1997 Aug;19(3):265-286.
Bone morphogenetic proteins(BMPs) are a group of transforming growth factor beta(TGF-beta)-related factors and multifunctional proteins, especially the only known biologic factors capable of inducing endochondral bone formation at an extraskeletal... -
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- Bioassay of human tooth protein blotted polyvinylidene difluoride(PVDF) membrane
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Kang N, Hong JR, Choung PH
- KMID: 1961104
- J Korean Assoc Oral Maxillofac Surg.
- 2004 Jun;30(3):186-192.
PURPOSE: Human tooth proteins are highly heterogeneous, comprising diverse proteins derived from a number of genes. The attempts to identify protein for activity of tooth matrix proteins have been defied... -
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- Effect of Guanylate Cyclase Inhibition on the Concentration of Nitrite in Culture Medium of Vascular Smooth Muscle Cell
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Jo HC, Jang NS, Rhee JA, Kim SY, Choi HC, Lee KY, Kim WJ
- KMID: 2096762
- J Korean Soc Vasc Surg.
- 1999 Nov;15(2):186-194.
PURPOSE: Nitric oxide (NO) exerts the relaxant effect in vascular smooth muscle cells (VSMC) by activating soluble guanylate cyclase (sGC), which produces cyclic guanidine monophosphate (cGMP) in the cell. This... -
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- Two Cases of Chloromethylisothiazolinone and Methylisothiazolinone-associated Toxic Lung Injury
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Lee E, Son SK, Yoon J, Cho HJ, Yang SI, Jung S, Do KH, Cho YA, Lee SY, Park DU, Hong SJ
- KMID: 2408663
- J Korean Med Sci.
- 2018 Apr;33(16):e119.
- doi: 10.3346/jkms.2018.33.e119
Previous animal studies have not conclusively determined the association between exposure to humidifier disinfectants (HDs) containing 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT) and/or 2-methyl-4-isothiazolin-3-one (MIT) and development of HD-associated lung injuries. Nonetheless, patients exposed... -
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- Effects of Contact Inhibitionof Entamoeba histolytica Trophozoites to Human Colon Epithelial Cells in Proinflammatory Cytokine Gene Expression in Colon Epithelial Cells Induced by E.histolytica
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Kim JM, Jung HC, Lee KM, Chin YJ, Kim YJ, Song IS, Kim CY
- KMID: 1772387
- Korean J Gastroenterol.
- 1997 Aug;30(2):194-203.
BACKGROUND AND AIMS: Entamoeba histolytica can cause invasive disease by clisruption of the intestinal barriers and subsequent lysis of the intestinal cells. Adherence to and contact-dependent killing of host cells... -
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- Detection of Rare Cancer Cells in the Blood by RNA Extraction of Filtered Mononuclear Cells and Reverse Transcription-PCR
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Jeon CH, Shin KC, Choi EY, Jung SB
- KMID: 2145396
- J Lab Med Qual Assur.
- 2011 Dec;33(2):111-118.
BACKGROUND: To enhance the cancer cell detection rate in blood, we tried to detect cancer cells by blood filtration, RNA extraction and reverse transcription (RT)-PCR in the filtered mononuclear cells... -
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- Distinct Pattern of GAD65 and GAD67 Gene Expression in the Pancreas of NOD Mouse
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Ko IY, Kang Y
- KMID: 2137369
- J Korean Diabetes Assoc.
- 1997 Sep;21(3):243-253.
BACKGROUND: Glutamic acid decarboxylase(GAD; EC 4.1.1.15), one of the major B-cell autoantigens in IDDM, is an enzyme which catalyzes the synthesis of major inhibitory neurotransmitter, r-aminobutyric acid (GARA), in the... -
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- Diagnosis of Causative Fungi of Onychomycosis Using Polymerase Chain Reaction and Restriction Enzyme Analysis
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Chae HJ, Baek SC, Cho BK
- KMID: 1551667
- Korean J Med Mycol.
- 1999 Jun;4(1):6-14.
BACKGROUND: Onychomycosis has become one of the common fungal infection. However, highly reliable and sensitive methods of detecting and identifying causative fungi of onychomycosis are not established yet. Polymerase chain... -
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