J Korean Med Sci.
2018 Apr;33(16):e119. 10.3346/jkms.2018.33.e119.
Two Cases of Chloromethylisothiazolinone and Methylisothiazolinone-associated Toxic Lung Injury
- Affiliations
-
- 1Department of Pediatrics, Chonnam National University Hospital, Gwangju, Korea.
- 2Department of Pediatrics, Pusan National University Children's Hospital, Yangsan, Korea.
- 3Department of Pediatrics, Childhood Asthma and Atopy Center, Environmental Health Center, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. sjhong@amc.seoul.kr
- 4Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
- 5Department of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
- 6Department of Environmental Health, Korea National Open University, Seoul, Korea.
- KMID: 2408663
- DOI: http://doi.org/10.3346/jkms.2018.33.e119
Abstract
- Previous animal studies have not conclusively determined the association between exposure to humidifier disinfectants (HDs) containing 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT) and/or 2-methyl-4-isothiazolin-3-one (MIT) and development of HD-associated lung injuries. Nonetheless, patients exposed to HDs containing only CMIT and/or MIT showed clinically similar lung injuries to those exposed to HDs containing polyhexamethylene guanidine (PHMG) or oligo (2-[2-ethoxy]ethoxyethyl) guanidinium chloride (PGH). Here, we report twin sisters with lung injuries associated with exposure to CMIT/MIT-containing HDs. At 6 months of age, a younger twin sister presented with the 3-day history of cough, sputum, and respiratory difficulty. Chest radiography revealed multiple patchy consolidation and ground-glass opacities with pneumothorax and pneumomediastinum. Thoracostomy was performed due to pneumothorax at admission and she was discharged at 11 days of hospitalization. At 5 years of age, multiple tiny nodules and faint centrilobular ground-glass opacities were observed with the small pneumatocele. The elder sister visited a tertiary hospital due to dyspnea at 12 months of age. Chest radiography showed consolidation, pneumomediastinum, and pulmonary interstitial emphysema. There was no response to the administration of immunosuppressant drugs and antifibrotic agents. At 5 years of age, chest CT revealed ground-glass opacity and multiple tiny centrilobular ground-glass opacities nodules in both lungs with exercise intolerance.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Major concerns regarding lung injury and related health conditions caused by the use of humidifier disinfectant
- The Pathological Findings of Chloromethylisothiazolinone and Methylisothiazolinone-associated Lung Injury
- Eye irritation tests of polyhexamethylene guanidine phosphate (PHMG) and chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) using a tissue model of reconstructed human cornea-like epithelium
- Review of Inhalation Health Risks Involving Chloromethylisothiazolinone (CMIT) and Methylisothiazolinone (MIT) Used as Disinfectants in Household Humidifiers
- Humidifier disinfectant lung injury, how do we approach the issues?
