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Flow Cytometry for the Diagnosis of Primary Immunodeficiency Diseases: A Single Center Experience

Kwon WK, Choi S, Kim HJ, Huh HJ, Kang JM, Kim YJ, Yoo KH, Ahn K, Cho HK, Peck KR, Jang JH, Ki CS, Kang ES

PURPOSE: While there is an urgent need for diagnosis and therapeutic intervention in patients with primary immunodeficiency diseases (PIDs), current genetic tests have drawbacks. We retrospectively reviewed the usefulness of...
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Seropositivity of Hepatitis C Virus among Persons affected Leprosy in Korea

Kim JP, Kang KH, Park JM

BACKGROUND: Leprosy is a contagious chronic granulomatous disease and is a disease that is associated with defects in cellular immunity. A high prevalence of hepatitis C virus infection in leprosy...
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Crohn's Disease Initially Presenting as Vulvar Swelling

Lee KG, Koh BY, Kwon ES, Myung KB, Cheong SH

  • KMID: 2436628
  • Korean J Dermatol.
  • 2018 Jan;56(1):49-52.
Crohn's disease is a chronic granulomatous disease involving any part of gastrointestinal tract. The skin is a common site of extraintestinal involvement in Crohn's disease. The most common sites of...
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Use of Stem Cell in Fetal Therapy: Current Status and Future Perspectives

Lee SW

During the past decades, there has been a great evolution in the field of fetal therapy for congenital defects. Prenatal screening or diagnostic methods including non-invasive and invasive methods and...
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A Case of Sarcoidosis of the Nasal Septum

Choi SY, Cha WW, Song K, Choi MS

Sarcoidosis is a chronic granulomatous disease, involving multisystem, confirmed by the presence of non-caseating granulomas. Sinonasal involvement in sarcoidosis is rare and difficult to diagnose since the symptoms of nasal...
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Targeted busulfan and fludarabine-based conditioning for bone marrow transplantation in chronic granulomatous disease

Ju HY, Kang HJ, Hong CR, Lee JW, Kim H, Song SH, Yu KS, Jang IJ, Park JD, Park KD, Shin HY, Kim JG, Ahn HS

Chronic granulomatous disease (CGD) is a primary immunodeficiency disease caused by impaired phagocytic function. Hematopoietic stem cell transplantation (HSCT) is a definitive cure for CGD; however, the use of HSCT...
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Concomitant use of corticosteroid and antimicrobials for liver abscesses in patients with chronic granulomatous disease

Shin KS, Lee MS

Chronic granulomatous disease (CGD) is a rare inherited disorder caused by defective nicotinamide adenine dinucleotide phosphate oxidase enzyme and characterized by recurrent bacterial and fungal infections. Although liver abscess is...
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A Case of Borderline Lepromatous Leprosy Masquerading as Chronic Eczema

Kim HR, Kwon HJ, Kim YI, Park KD, Chung H, Park JS

Leprosy is a chronic granulomatous disease affecting the skin and peripheral nervous system. Because of its variable manifestations, leprosy can be misdiagnosed as syphilis, sarcoidosis, psoriasis and eczema. A 73...
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A Case of Tuberculoid Leprosy without Sensory Loss in a Male Immigrant

Lee SW, Kim YU, Kim KJ, Heo EP

  • KMID: 2245939
  • Korean J Dermatol.
  • 2015 Jul;53(6):466-469.
Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae. The prevalence and number of new cases have recently markedly decreased in Korea, and the possibility of leprosy can therefore...
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Long-term outcome of patients with p22phox-deficient chronic granulomatous disease on Jeju Island, Korea

Kang HS, Hwang G, Shin KS

PURPOSE: This study investigated the long-term clinical outcomes of patients with p22(phox)-deficient chronic granulomatous disease (CGD) on Jeju Island and retrospectively evaluated the effects of interferon-gamma (IFN-gamma) prophylaxis. METHODS: The medical...
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Middle Ear Actinomycosis Involving Facial Nerve and Lateral Semicircular Canal

Lee S, Park HJ, Cho HH

Actinomycosis is a chronic granulomatous disease caused by the species of Actinomyces. Although it has become a rare disease in the present antibiotics era, it still needs long term antibiotic...
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Lepromatous Leprosy Misdiagnosed as Rheumatoid Arthritis

Lim HS, Yun SJ, Lee JB, Kim SJ, Lee SC, Won YH

  • KMID: 1734194
  • Korean J Dermatol.
  • 2014 Nov;52(11):813-816.
Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae and may manifest variable symptoms and signs. A 63-year-old woman developed multiple erythematous subcutaneous nodules on her trunk and extremities...
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Identification of a Novel Mutation in the CYBB Gene, p.Asp378Gly, in a Patient With X-linked Chronic Granulomatous Disease

Song SM, Park MR, Kim DS, Kim J, Kim YJ, Ki CS, Ahn K

Chronic granulomatous disease (CGD) is a rare immunodeficiency disease, which is characterized by the lack of a functional nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in phagocytes. The disease presents leukocytosis,...
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A Case of Esophageal Obstruction Complicated in a Patient with Chronic Granulomatous Disease: Esophageal obstruction in Chronic Granulomatous Disease

Kim JS, Hwang J, Choi YH, Kim WS, Kim JG

  • KMID: 1705187
  • Korean J Pediatr Infect Dis.
  • 2014 Apr;21(1):53-58.
Chronic granulomatous disease (CGD) is an inherited immunodeficient disease characterized by recurrent infections and granuloma formation. Granulomatous obstruction of esophagus is one of the rare complications of CGD. The use...
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Malakoplakia in the Urinary Bladder

Baik S, Kim CS, Lim DH

Malakoplakia is a rare chronic granulomatous disease, which was originally described in the urinary bladder, but can involve many other organs and soft tissues. Malakoplakia is often associated with immunosuppression...
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Rapid Determination of Chimerism Status Using Dihydrorhodamine Assay in a Patient with X-linked Chronic Granulomatous Disease Following Hematopoietic Stem Cell Transplantation

Kim HY, Kim HJ, Ki CS, Kim DW, Yoo KH, Kang ES

Chronic granulomatous disease (CGD) is a rare genetic disease, which is caused by defects in the NADPH oxidase complex (gp91phox, p22phox, p40phox, p47phox, and p67phox) of phagocytes. This defect results...
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Chronic Granulomatous Disease on Jeju Island, Korea

Cho M, Shin KS

Chronic granulomatous disease (CGD) is a rare inherited disorder of a defective NADPH oxidase enzyme, resulting in very low or no production of superoxide and subsequent reactive oxygen species. Consequently,...
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Necrobiosis Lipoidica Presenting as Unilateral Papulovesicular Eruptions on the Lower Leg

Lyu SM, Cheong SH, Byun JY, Choi YW, Oh CW, Choi HY

  • KMID: 2247245
  • Korean J Dermatol.
  • 2013 Mar;51(3):215-218.
Necrobiosis lipoidica is a chronic granulomatous disease that has a well-known association with diabetes mellitus. It usually affects the bilateral lower legs of middle-aged women. Over time, the clinical features...
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Differential diagnosis and treatment of periodontitis-mimicking actinomycosis

Kim NR, Park JB, Ko Y

  • KMID: 2438864
  • J Periodontal Implant Sci.
  • 2012 Dec;42(6):256-260.
PURPOSE: Actinomycosis is an uncommon chronic granulomatous disease that presents as a slowly progressive, indolent, indurated infiltration with multiple abscesses, fistulas, and sinuses. The purpose of this article is to...
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A case report of chronic granulomatous disease presenting with aspergillus pneumonia in a 2-month old girl

Lee E, Oh SH, Kwon JW, Kim BJ, Yu J, Park CJ, Hong SJ

Chronic granulomatous disease (CGD) is an uncommon inherited disorder caused by mutations in any of the genes encoding subunits of the superoxide-generating phagocyte NADPH oxidase system, which is essential for...
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