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Adrenal metastasis in sequentially developed combined hepatocellular carcinoma-cholangiocarcinoma: A case report

Nugroho A, Lee KW, Lee KB, Kim HS, Kim H, Yi NJ, Suh KS

The incidence of combined hepatocellular carcinoma-cholangiocarcinoma (cHCC-CC) in a single patient accounts for only 0.4 to 14% of all primary liver cancer. However, the prognosis of its intrahepatic cholangiocarcinoma (ICC)...
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Long-term study of the association of adipokines and glucose variability with diabetic complications

Cha JJ, Min HS, Kim K, Lee MJ, Lee MH, Kim JE, Song HK, Cha DR, Kang YS

BACKGROUND/AIMS: Recent studies have suggested an important role of adipokines in the development of insulin resistance and diabetes mellitus. The clinical relevance of adipokines on long-term outcomes in patients with...
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Glypican-3 level assessed by the enzyme-linked immunosorbent assay is inferior to alpha-fetoprotein level for hepatocellular carcinoma diagnosis

Jeon Y, Jang ES, Choi YS, Kim JW, Jeong SH

BACKGROUND/AIMS: Glypican-3 (GPC3) protein is highly expressed in hepatocellular carcinoma (HCC) tissue. It has been suggested as a diagnostic biomarker, but its inconsistent performance means that it requires further assessment....
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Correlation of Glypican-4 Level with Basal Active Glucagon-Like Peptide 1 Level in Patients with Type 2 Diabetes Mellitus

Lee SA, Koh G, Cho SJ, Yoo SY, Chin SO

BACKGROUND: Previous studies have reported that glypican-4 (GPC4) regulates insulin signaling by interacting with insulin receptor and through adipocyte differentiation. However, GPC4 has not been studied with regard to its...
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A New Cell Block Method for Multiple Immunohistochemical Analysis of Circulating Tumor Cells in Patients with Liver Cancer

Nam SJ, Yeo HY, Chang HJ, Kim BH, Hong EK, Park JW

PURPOSE: We developed a new method of detecting circulating tumor cells (CTCs) in liver cancer patients by constructing cell blocks from peripheral blood cells, including CTCs, followed by multiple immunohistochemical...
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Clinical Utility of Plasma Glypican-3 and Osteopontin as Biomarkers of Hepatocellular Carcinoma

Lee HJ, Yeon JE, Suh SJ, Lee SJ, Yoon EL, Kang K, Yoo YJ, Kim JH, Seo YS, Yim HJ, Byun KS

  • KMID: 1774546
  • Gut Liver.
  • 2014 Mar;8(2):177-185.
BACKGROUND/AIMS: alpha-Fetoprotein (AFP) is the biomarker most widely used to detect hepatocellular carcinoma (HCC), despite its suboptimal diagnostic accuracy. Glypican-3 (GPC3) and osteopontin (OPN) are secreted glycoproteins that are reportedly...
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Recent advances in systemic chemotherapy of hepatocellular carcinoma

Kim BH, Park JW

Sorafenib, as the first approved molecularly targeted agent for hepatocellular carcinoma (HCC), has changed the treatment paradigm for patients with advanced HCC. Although a significant survival advantage has been achieved...
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A case of isolated metastatic hepatocellular carcinoma arising from the pelvic bone

Jung KS, Park KH, Chon YE, Lee SR, Park YN, Lee DY, Seong JS, Park JY

Reports of metastatic hepatocellular carcinoma (HCC) without a primary liver tumor are rare. Here we present a case of isolated HCC that had metastasized to the pelvic bone without a...
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A Comparative Study of Gene Microarray between Normal and Diabetic Keratocyte in Rat Cornea

Lee JS, Lee JR, Jung SC, Oum BS

  • KMID: 2125578
  • J Korean Ophthalmol Soc.
  • 2003 Jul;44(7):1629-1638.
PURPOSE: To differentiate the genes that are up-regulated or down-regulated and the cellular morphology in the corneal stromal cells between normal and diabetic rat. METHODS: After isolation with trizol (GIBCO,...
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