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Increasing the alpha 2, 6 Sialylation of Glycoproteins May Contribute to Metastatic Spread and Therapeutic Resistance in Colorectal Cancer

Park JJ, Lee M

  • KMID: 1712321
  • Gut Liver.
  • 2013 Nov;7(6):629-641.
Abnormal glycosylation due to dysregulated glycosyltransferases and glycosidases is a key phenomenon of many malignancies, including colorectal cancer (CRC). In particular, increased ST6 Gal I (beta-galactoside alpha 2, 6 sialyltransferase)...
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Lipid rafts are important for the association of RANK and TRAF6

Ha H, Kwak HB, Le SW, Kim HH, Lee ZH

  • KMID: 1109317
  • Exp Mol Med.
  • 2003 Aug;35(4):279-284.
Rafts, cholesterol- and sphingolipid-rich membrane microdomains, have been shown to play an important role in immune cell activation. More recently rafts were implicated in the signal transduction by members of...
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Comparison of carbohydrate moieties of sparganum proteins of the snake, mouse and those of adult worm

Yang HJ

The carbohydrate moieties of larval sparganum proteins in two different species, the snakes, Elaphe rufodorsata, the Balb/c mouse and those of the adult worm, Spirometra erinacei, were compared using five...
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Expression of CD40 and Fas Ligand in Bowen's Disease, Squamous Cell Carcinoma and Basal Cell Carcinoma

Jang TJ

Impaired regulation of apoptosis is known to be associated with the development of various cancers, and Fas/Fas-ligand (FasL) is known to play an important role in apoptosis. CD40 is a...
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Immunohistochemical Analysis of CD44s and CD44v6 in Endometriosis and Adenomyosis: Comparison with normal, hyperplastic, and malignant endometrium

Lin ZH, Cho SJ, Jeong HJ, Kim HK, Kim IS

The expression patterns of CD44s and CD44v6 were immunohistochemically compared with those of normal, hyperplastic and malignant endometrium. In normal endometria (n=37), endometrioses (n=46) and adenomyoses (n=20), the surface and...
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Activation domain in P67phox regulates the steady state reduction of FAD in gp91phox

Han CH, Lee MH

  • KMID: 1103471
  • J Vet Sci.
  • 2000 Jun;1(1):27-31.
An activation domain in p67(phox) (residues 199-210) is critical for regulating NADPH oxidase activity in cell-free system [10] To determine the steady state reduction of FAD, thioacetamide-FAD was reconstituted in...
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Expressions of Uroplakins in the Mouse Urinary Bladder with Cyclophosphamide-Induced Cystitis

Choi SH, Byun Y, Lee G

Even though uroplakins (UPs) are believed to serve a strong protective barrier against toxic materials, cyclophosphamide (CP) causes extensive cystitis. We investigated the expression of UPs in the urothelium in...
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Tissue Microarray Analysis of Fas and FasL Expressions in Human Non-small Cell Lung Carcinomas; with Reference to the p53 and bcl-2 Overexpressions

Myong NH

Lack of surface Fas expression is a main route for apoptotic resistance which is considered an important mechanism of tumorigenesis and tumor progression. Fas and FasL expressions in 110 non-small...
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Tetraspanin CD9 induces MMP-2 expression by activating p38 MAPK, JNK and c-Jun pathways in human melanoma cells

Hong IK, Kim YM, Jeoung DI, Kim KC, Lee H

  • KMID: 1056236
  • Exp Mol Med.
  • 2005 Jun;37(3):230-239.
Expression of matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9), which correlates with tumor invasion and metastasis, has been known to be regulated by several intracellular signaling pathways. Since the CD9...
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Fas-mediated apoptosis and expression of related genes in human malignant hematopoietic cells

Kim KM, Lee KH, Hong YS, Park HY

  • KMID: 755108
  • Exp Mol Med.
  • 2000 Dec;32(4):246-254.
Fas transduces apoptotic signals upon cross-linking with the Fas ligand (FasL), which is experimentally replaced by agonistic anti-Fas monoclonal antibodies (mAb). Of eight human malignant hematopoietic cell lines...
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Upregulation of extracellular matrix metalloproteinase inducer (EMMPRIN) and gelatinases in human atherosclerosis infected with Chlamydia pneumoniae: The potential role of Chlamydia pneumoniae infection in the progression of atherosclerosis

Choi EY, Kim DS, Hong BK, Kwon HM, Song YG, Byun KH, Park HY, Whang KC, Kim HS

  • KMID: 1121092
  • Exp Mol Med.
  • 2002 Dec;34(6):391-400.
Chlamydia pneumoniae infection implicated as an important etiologic factor of atherosclerosis, especially in coronary artery disease (CAD), was found in vitro to be associated with the induction of matrix...
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