- A Pregnant Woman with Type 2 Diabetes Unintentionally Exposed to Metformin and Voglibose until the Second Trimester of Pregnancy: A Case Report
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Kim YU, Kwak JH, Yeo SH, Moon SS, Lee YS
- KMID: 2362987
- J Korean Diabetes.
- 2016 Dec;17(4):277-281.
- doi: 10.4093/jkd.2016.17.4.277
Use of oral hypoglycemic agents during pregnant women with type 2 diabetes is controversial due to safety issues. Recently, randomized controlled trials support short-term safety of glyburide and metformin for... -
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- Medical Therapy in Pregnant Women with Diabetes
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Lee SH, Ahn J, Kim J
- KMID: 2059852
- J Korean Diabetes.
- 2011 Dec;12(4):201-204.
- doi: 10.4093/jkd.2011.12.4.201
Pregnant women with diabetes are at greater risk for adverse outcomes, such as miscarriage, macrosomia, and preterm birth. Advances in the care of diabetes have reduced maternal and perinatal mortality... -
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- Effect of Sulfonylureas Administered Centrally on the Blood Glucose Level in Immobilization Stress Model
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Sharma N, Sim YB, Park SH, Lim SM, Kim SS, Jung JS, Hong JS, Suh HW
- KMID: 1791419
- Korean J Physiol Pharmacol.
- 2015 May;19(3):197-202.
- doi: 10.4196/kjpp.2015.19.3.197
Sulfonylureas are widely used as an antidiabetic drug. In the present study, the effects of sulfonylurea administered supraspinally on immobilization stress-induced blood glucose level were studied in ICR mice. Mice... -
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- Effect of Cisapride on ATP-sensitive K Channel of Ventricular Cell
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Moon SG, In BH, Kim WH, Ko JK
- KMID: 1894752
- Korean Circ J.
- 1998 Jan;28(1):76-81.
- doi: 10.4070/kcj.1998.28.1.76
BACKGROUND: It has been generally accepted that Cisapride (Prepulsid?or propulsid?), a widely used gastrointestinal prokinetic agent, is associated with Torsades de Points, a life-threatening arrhythmia. Recently, cisapride-induced APD (action potential... -
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- A Case of Term Delivery with Diagnosis of Severe Oligohydramnios after Exposure to Glimepiride, Metformin and Antihypertensive agents Including Angiotensin Receptor Antagonist up to Approximately 20 Weeks of Pregnancy
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Kwak DW, Yoo IS, Choi JS
- KMID: 2280926
- Korean J Perinatol.
- 2013 Jun;24(2):95-100.
- doi: 10.14734/kjp.2013.24.2.95
Various fetal and maternal conditions are known to be associated with oligohydramnios. In general, oligohydramnios developed early in pregnancy is less common but frequently has a poor prognosis. The use... -
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- The Effects of Glyburide on Apoptosis and Endoplasmic Reticulum Stress in INS-1 Cells in a Glucolipotoxic Condition
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Kwon MJ, Chung HS, Yoon CS, Ko JH, Jun HJ, Kim TK, Lee SH, Ko KS, Rhee BD, Kim MK, Park JH
- KMID: 1857503
- Diabetes Metab J.
- 2011 Oct;35(5):480-488.
- doi: 10.4093/dmj.2011.35.5.480
BACKGROUND: beta-cell death due to endoplasmic reticulum (ER) stress has been regarded as an important pathogenic component of type 2 diabetes. The possibility has been suggested that sulfonylurea, currently being... -
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- Low glibenclamide concentrations affect endoplasmic reticulum stress in INS-1 cells under glucotoxic or glucolipotoxic conditions
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Kwon MJ, Chung HS, Yoon CS, Lee EJ, Kim TK, Lee SH, Ko KS, Rhee BD, Kim MK, Park JH
- KMID: 1776456
- Korean J Intern Med.
- 2013 May;28(3):339-346.
- doi: 10.3904/kjim.2013.28.3.339
BACKGROUND/AIMS: beta-Cell apoptosis caused by increased endoplasmic reticulum (ER) stress is an important pathogenic component of type 2 diabetes mellitus. In theory, sulfonylureas, used for the treatment of diabetes, can... -
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- Differential Changes of ATP-sensitive Potassium Channel Current after Hypoxia-reperfusion Treatment in Mouse Neuroblastoma 2a (N2a) Cell
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Park JH
- KMID: 2071578
- Korean J Physiol Pharmacol.
- 2002 Aug;6(4):183-186.
Ischemic damage is one of the most serious problems. The openers of KATP channel have been suggested to have an effect to limit the ischemic damage. However, it is not... -
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- Analgesic effects of eucalyptus essential oil in mice
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Lee G, Park J, Kim MS, Seol GH, Min SS
- KMID: 2449820
- Korean J Pain.
- 2019 Apr;32(2):79-86.
- doi: 10.3344/kjp.2019.32.2.79
BACKGROUND: The use of aroma oils dates back to at least 3000 B.C., where it was applied to mummify corpses and treat the wounds of soldiers. Since the 1920s, the... -
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- Depolarizing Mechanisms of Acetylcholine in Gastric Smooth Muscle
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Jun JY, Yeum CH, Moon SH, Oh HK, Park YW, Lee SJ, Yun PJ
- KMID: 2240620
- Korean J Gastroenterol.
- 1998 Apr;31(4):421-431.
BACKGROUND AND AIMS: Acetylcholine which is a major excitatory neurotransmitter, depolarizes gastric smooth muscle cells. The aim of this study was to investigate the ionic mechanisms of acetylcholine-induced depolarization in... -
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- Effect of pH on the ATP-sensitive K+ channel in aortic smooth muscle cells from rats
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Kim SH, Kim IS, Kim HS, Jeon BH, Chang SJ
- KMID: 1554766
- Korean J Physiol Pharmacol.
- 1997 Oct;1(5):555-563.
The effects of pH on K+ currents were investigated in single smooth muscle cells isolated from the thoracic aorta of Wistar-Kyoto rats. Whole-cell K+ currents were recorded in the conventional configuration of the... -
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- Effect of Pinacidil on the Contraction of Rabbit Carotid Artery
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Yoon SM, Lee KJ, Kim EJ, Lee YW
- KMID: 1549027
- J Korean Neurosurg Soc.
- 1998 Oct;27(10):1344-1351.
The effect of pinacidil, a K+ channel opener, on the contraction of rabbit carotid artery was investigated by using muscle contraction and Ca2= uptake experiments. Pinacidil reduced phenylephrine-induced contraction by... -
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- Stretch-activated K+ Channels in Rat Atrial Myocytes
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Youm JB
- KMID: 1607519
- Korean J Physiol Pharmacol.
- 2003 Dec;7(6):341-348.
Mechanical stimuli to the cardiac myocytes initiate many biochemical and physiological events. Stretch-activated cation channels have been suggested to mediate these events. In this study, cell-attached and inside-out excised-patch clamp... -
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- Effects of PGI2 on the ATP-sensitive Potassium Channel Activity in the Isolated Rat Cardiac Myocytes
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Ju JM, Choi DS, Piao LH, Kim JH
- KMID: 1613959
- Chonnam Med J.
- 2003 Sep;39(3):162-170.
It was examined that the effects of PGI2 on the ATP-sensitive potassium channel (KATP channel) activity in the rat myocardium using patch clamp and action potential measurement techniques. PGI2, doses... -
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- Altered Vascular Response to the K+induced Vasorelaxation in Aortic Smooth Muscle of Renal Hypertensive Rats
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Jun JY, Yeum CH, Yoon PJ, Liee JH, Choi HH, Park YW, Kim JH
- KMID: 2298026
- Korean Circ J.
- 2000 Aug;30(8):980-988.
- doi: 10.4070/kcj.2000.30.8.980
BACKGROUND: An increase of the extracellular K+concentrations up to about 8 mM in the isolated vessels causes relaxation in pre-contracted state. In order to elucidate the mechanisms of K+induced relaxation... -
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- Effects of Glibenclamide and L-NAME on Hypoxic Pulmonary Vasoconstriction in Rats
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Oh AY, Kim SD
- KMID: 2091642
- Korean J Anesthesiol.
- 2001 Dec;41(6):741-747.
- doi: 10.4097/kjae.2001.41.6.741
BACKGROUND: This study was performed with NW-nitro-L-arginine methyl ester ((L)-NAME), an inhibitor of EDRF production, and glibenclamide, which closes ATP dependent K+ channels, to determine their effects on hypoxic pulmonary... -
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- The Role of Mitochondrial ATP-sensitive Potassium Channel on Intestinal Pacemaking Activity
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Kim BJ, Kim KW
- KMID: 1600073
- Korean J Physiol Pharmacol.
- 2005 Aug;9(4):209-213.
Interstitial cells of Cajal (ICCs) are the pacemaker cells that generate slow waves in the gastrointestinal (GI) tract. In the present study, we investigated the effect of mitochondrial ATP-sensitive potassium... -
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- K+ -ATP - Channel Opener as a Potential Treatment for Erectile Dysfunction
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Moon DG, Byun HS, Kim JJ
- KMID: 2298846
- Korean J Androl.
- 1998 Jun;16(1):41-48.
PURPOSE: Intracavernous injection of PGE1 or papaverine is widely used in the diagnosis and treatment of erectile dysfunction. However, these drugs have several side effects such as pain, priapism, and... -
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- Effects of Propofol on Arginine Vasopressin-induced Contraction in Isolated Human Gastroepiploic Artery
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Lee SJ, Baik SW, Cho HR, Kim WS, Baek SH
- KMID: 1763523
- Korean J Anesthesiol.
- 2008 Jun;54(6):662-668.
- doi: 10.4097/kjae.2008.54.6.662
BACKGROUND: Arginine vasopressin has been used by prophylactic treatment of vasodilatory shock during coronary artery bypass graft (CABG). Vasopressin may be a cause of spasm in graft artery during CABG.... -
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- Effect of prostaglandins D2, E2 and I2 on the regulation of KATP channel activity in rat cardiac myocytes
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Ju JM, Nah SY, Kim JH
- KMID: 2071552
- Korean J Physiol Pharmacol.
- 1999 Oct;3(5):507-512.
Contribution of prostaglandins D2, E2 and I2 (PGD2, PGE2 and PGI2) on the regulation of ATP-sensitive K+ channel (KATP channel) was investigated in isolated single rat ventricular cardiac myocytes using the patch clamp... -
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