Korean J Anesthesiol.  2008 Jun;54(6):662-668. 10.4097/kjae.2008.54.6.662.

Effects of Propofol on Arginine Vasopressin-induced Contraction in Isolated Human Gastroepiploic Artery

• Lee SJ
• Baik SW
• Cho HR
• Kim WS
• Baek SH

• KMID: 1763523
• DOI: http://doi.org/10.4097/kjae.2008.54.6.662

Abstract

BACKGROUND: Arginine vasopressin has been used by prophylactic treatment of vasodilatory shock during coronary artery bypass graft (CABG). Vasopressin may be a cause of spasm in graft artery during CABG. We evaluated the effect of propofol on vasopressin-induced contraction in human gastroepiploic artery (GEA).
METHODS
Human GEA were obtained from 35 patients (43-74 yr), undergoing subtotal gastrectomy. Vasopressin-induced a concentration contractions (10(-9) to 10(-6) M) were measured after exposed to without propofol, propofol 10(-5), 10(-4), 10(-3) M. After endothelium denuding vasopressin-induced a concentration contractions were measured with or without propofol 10(-3) M in calcium free solution. In the denuded vascular rings, with or without pretreatment of glibenclamide (10(-5) M), nicorandil (10(-5) M), or diltiazem (10(-5) M) were exposed to with or without propofol 10(-3) M, and vasopressin-induced concentration contractions were measured.
RESULTS
Vasopressin-induced concentration contraction on human GEA was independent of functional endothelium. Propofol (10(-4), 10(-3) M) attenuated the vasopressin-induced contraction in the human GEA. Diltiazem attenuated the vasopressin-induced contraction in the human GEA. ATP-sensitive potassium channel does not affect the inhibition effect of propofol on vasopressin-induced contraction
CONCLUSIONS
Usual anesthetic dose of propofol does not inhibit vasopressin-induced contraction on human GEA. High dose (>10(-4) M) propofol attenuated vasopresssi-induced contraction on GEA.

Keyword

coronary artery bypass grafting; propofol; vasopressin

MeSH Terms

Arginine
Arginine Vasopressin
Arteries
Calcium
Contracts
Coronary Artery Bypass
Diltiazem
Endothelium
Gastrectomy
Gastroepiploic Artery
Glyburide
Humans
Nicorandil
Potassium Channels
Propofol
Shock
Spasm
Transplants
Vasopressins
Arginine
Arginine Vasopressin
Calcium
Diltiazem
Glyburide
Nicorandil
Potassium Channels
Propofol
Vasopressins