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Glutathione recycling is attenuated by acute ethanol feeding in rat liver

Oh SI, Kim CI, Chun HJ, Lee MS, Park SC

The mechanism for ethanol-induced oxidative stress has been disputed because of the controversies on modulation of radical generating and scavenging activities by ethanol. In the present work, we attempted...
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Interaction between Inorganic Mercury and Selenium on Tissue Sulfhydryl Groups and Glutathione-linked Enzymes in Rats

Oh SH, Lee MH

The effect of selenium on the tissue sulfhydryl group content and lipid peroxide-destorying enzyme system in the liver, kidney and testis of rat treated with mercury was investigated. The male...
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Effects of N-acetyl-L-cysteine and Glutathione on Antioxidant Status of Human Serum and 3T3 Fibroblasts

Hong SY, Yang JO, Lee EY, Lee ZW

The effectiveness of several sulfhydryl compounds in the treatment of paraquat intoxication has been previously tested based on their antioxidant ability. However, practical guidelines for their clinical use remain to...
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Enhancements of Mouse Hepatic Cytosol Enzyme Activities Involved in UDP-Glucuronic Acid Synthesis, Glutathione Reduction and Conjugation with Butylated Hydroxyanisole (BHA) and Its Structural Analogs

Cha YN, Chung JH, Heine HS, Hong SS

Activities of hepatic cytosol enzymes involved in UDP-g1ucuronic acid synthesis as well as in glutathione reduction and conjugation systems were determined following administrations of butylated hydroxyanisole (approximately 5 mmol/kg body...
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Iron Supplementation in Experimental Hyperthyroidism: Effects on Oxidative Stress in Skeletal Muscle Tissue

Seymen HO, Civelek S, Seven A, Yigit G, Hatemi H, Burcak G

This study was designed to investigate the effects of iron supplementation on the parameters of oxidative stress in the skeletal muscle tissue of hyperthyroidism induced rats. Hyperthyroidism was found to...
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Effects of glutamate on dehydroascorbate uptake and Its enhanced vulnerability to the peroxidation in cerebral cortical slices

Song JH, Shin SH, Chung IM

  • KMID: 1121095
  • Exp Mol Med.
  • 2002 Dec;34(6):419-425.
Pro-oxidant properties of ascorbate have been studied with uses of brain tissues and neuronal cells. Here we address potential mechanism of ascorbate coupling with glutamate to generate oxidative stress,...
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Effects of L-NAME, a non-specific nitric oxide synthase inhibitor, on AlCl3-induced toxicity in the rat forebrain cortex

Stevanovic ID, Jovanovic , Jelenkovic A, Colic M, Stojanovic I, Ninkovic M

The present experiments were done to determine the effectiveness of a non-specific nitric oxide synthase inhibitor, N-nitro-L-arginine methyl ester (L-NAME), on oxidative stress parameters induced by aluminium chloride (AlCl3) intrahippocampal...
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Oxidative Stress-Activated NHE1 Is Involved in High Glucose-Induced Apoptosis in Renal Tubular Epithelial Cells

Wu Y, Zhang M, Liu R, Zhao C

PURPOSE: Diabetic nephropathy (DN) is a prevalent chronic microvascular complication of diabetes mellitus involving disturbances in electrolytes and the acid-base balance caused by a disorder of glucose metabolism. NHE1 is...
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Grape extracts suppress the formation of preneoplastic foci and activity of fatty acid synthase in rat liver

Kweon S, Kim Y, Choi H

  • KMID: 1093609
  • Exp Mol Med.
  • 2003 Oct;35(5):371-378.
This study was conducted to examine the effects of dietary grape extracts on preneoplastic foci formation in rat hepatocarcinogenesis, and related hepatic enzymes. Male Sprague-Dawley rats were fed basal diet...
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Influence of P53 on the radiotherapy response of hepatocellular carcinoma

Gomes AR, Abrantes A, Brito AF, Laranjo M, Casalta-Lopes JE, Goncalves , Sarmento-Ribeiro AB, Botelho MF, Tralhao JG

BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and it has a poor prognosis and few therapeutic options. Radiotherapy is one of the most effective forms...
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Acetoaminophen-induced accumulation of 8-oxodeoxyguanosine through reduction of Ogg1 DNA repair enzyme in C6 glioma cells

Wan J, Bae MA, Song BJ

  • KMID: 755668
  • Exp Mol Med.
  • 2004 Feb;36(1):71-77.
Large doses of acetaminophen (APAP) could cause oxidative stress and tissue damage through production of reactive oxygen/nitrogen (ROS/RNS) species and quinone metabolites of APAP. Although ROS/RNS are known to modify...
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Antidiabetic Effects of Corni Fructus Extract in Streptozotocin-Induced Diabetic Rats

Gao D, Li Q, Gao Z, Wang L

PURPOSE: Diabetes is the leading cause of end-stage renal failure. The present study was undertaken to characterize the effects of Corni Fructus on diabetic nephropathy in streptozotocin-induced diabetic rats and...
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