- Role of the ABCB1 Drug Transporter Polymorphisms in the Pharmacokinetics of Oseltamivir in Humans: a Preliminary Report
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Cha YJ, Ghim JL
- KMID: 2385963
- J Korean Med Sci.
- 2017 Sep;32(9):1542-1547.
- doi: 10.3346/jkms.2017.32.9.1542
Oseltamivir is a substrate of P-glycoprotein, an efflux drug transporter encoded by ABCB1. The objective of this study was to assess the role of ABCB1 (c.1236C>T, c.2677G>T/A, and c.3435C>T) polymorphisms... -
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- Pharmacokinetics of atorvastatin and sustained-release metformin fixed-dose combination tablets: two randomized, open-label, 2-way crossover studies in healthy male subjects under fed conditions
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Choi YK, Park SE, Kim EY, Park HJ, Kim EJ, Song GS, Ghim JL
- KMID: 2407001
- Transl Clin Pharmacol.
- 2017 Dec;25(4):190-195.
- doi: 10.12793/tcp.2017.25.4.190
Two separate studies were conducted to establish bioequivalence (BE) for two doses of atorvastatin/metformin sustained-release (SR) fixed dose combination (FDC) versus the same dosage of the individual component (IC) tablets... -
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- Genetic polymorphisms of CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 in Vietnamese-Koreans
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Lim YJ, Cha EY, Jung HE, Ghim JL, Lee SJ, Kim EY, Shin JG
- KMID: 2050939
- Transl Clin Pharmacol.
- 2014 Dec;22(2):70-77.
- doi: 10.12793/tcp.2014.22.2.70
The Vietnamese-Koreans, especially offspring between a Vietnamese mother and a Korean father constituted the highest proportion (64.2%) of total Kosian population according to a census in 2014. To evaluate genetic... -
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- The Development of Automated Bed-allocation Expert System in Clinical Research Ward
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Song SM, Kim JM, Ghim JL, Shin JG, Kim EY
- KMID: 2334519
- J Korean Soc Clin Pharmacol Ther.
- 2012 Jun;20(1):51-59.
BACKGROUND: Demands for complicated and long-term administration clinical trials have been increased since investigators actively involved in early stage clinical trials including first-in-human (FIH) trials. Research wards in our clinical... -
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- Comparison of Pharmacokinetic Characteristics and Safety Between JW Amlodipine(R) Tablet 5 mg and Novarsc(R) Tablet 5 mg in Healthy Male Volunteers
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Kim YH, Lim HS, Cho SH, Ghim JL, Choe S, Jung JA, Bae KS
- KMID: 2203222
- J Korean Soc Clin Pharmacol Ther.
- 2013 Dec;21(2):95-103.
- doi: 10.12793/jkscpt.2013.21.2.95
BACKGROUND: Amlodipine is a third-generation dihydropyridine calcium channel blocker, which has proven to be a useful drug against hypertension or angina. METHODS: This randomized, open-label, two-period, two-treatment, single-dose, crossover study was... -
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- Associations between HLA-A, -B, and -C alleles and iodinated contrast media– induced hypersensitivity in Koreans
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Kim EY, Choi SJ, Ghim JL, Kim MY, Seol JE, Oh M, Park CS, Shin JG
- KMID: 2525607
- Transl Clin Pharmacol.
- 2021 Jun;29(2):107-116.
- doi: 10.12793/tcp.2021.29.e10
A common cause of drug hypersensitivity reactions is iodinated contrast media (ICM). ICM-induced hypersensitivity had been considered to be a non-immunological reaction, but evidence for an immunological mechanism has increased... -
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- Comparison of Pharmacokinetic Characteristics and the Safety between Amlodipine Maleate Tablet 5 mg and Amlodipine Besylate Tablet 5 mg
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Choi HY, Kim JW, Lim HS, Cho SH, Ghim JL, Choe S, Jung JA, Lim J, Bae KS
- KMID: 2334517
- J Korean Soc Clin Pharmacol Ther.
- 2012 Jun;20(1):42-50.
BACKGROUND: Amlodipine is a third-generation dihydropyridine calcium channel blocker for treating hypertension. Though marketed primarily as a besylate salt, there have been some efforts to find other comparable salts. Among... -
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- Effects of mirodenafil on the hemodynamics in hypertensive patients taking amlodipine
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Choi HK, Shim EJ, Shon J, Jung JA, Ghim JL, Ryu JH, Bae KS, Shin JG
- KMID: 2290475
- Transl Clin Pharmacol.
- 2016 Jun;24(2):90-95.
- doi: 10.12793/tcp.2016.24.2.90
While phosphodiesterase type 5 inhibitors have been used for erectile dysfunction with acceptable safety profile, they can induce orthostatic hypotension in patients taking antihypertensive drugs with blood pressure lowering effect.... -
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- Comparison of Pharmacokinetics and Safety of Two Formulations of Letrozole (2.5 mg) in Healthy Male Volunteers
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Noh YH, Bae KS, Cho SH, Choe S, Ghim JL, Jung JA, Kim UJ, Jin SJ, Park HJ, Kim JC, Lim HS
- KMID: 2334533
- J Korean Soc Clin Pharmacol Ther.
- 2012 Dec;20(2):135-144.
BACKGROUND: Letrozole is an oral non-steroidal inhibitor of the aromatase enzyme, which has proven to be a useful drug against breast cancer. METHODS: This single-dose, randomized 2 x 2 crossover study... -
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- Development of a validated liquid chromatography-tandem mass spectrometry assay for the quantification of simvastatin acid, the active metabolite of simvastatin, in human plasma
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Park HJ, Hwang AK, Kim AR, Kim SH, Kim EH, Cho SH, Ghim JL, Choe S, Jung JA, Jin SJ, Bae KS, Lim HS
- KMID: 2383596
- Transl Clin Pharmacol.
- 2016 Mar;24(1):22-29.
- doi: 10.12793/tcp.2016.24.1.22
Simvastatin is a lipid-lowering drug that is metabolized to its active metabolite simvastatin acid (SA). We developed and validated a sensitive liquid chromatography-tandem mass spectrometry (LC/MS/MS) method to quantitate SA... -
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- Antiepileptic drug-induced severe cutaneous adverse reactions and HLA alleles: A report of five cases with lymphocyte activation test
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Kim EY, Kim MY, Park CS, Choi JH, Ghim JL, Kim HS, Shin JG
- KMID: 2457573
- Transl Clin Pharmacol.
- 2019 Jun;27(2):64-68.
- doi: 10.12793/tcp.2019.27.2.64
Antiepileptic drugs (AEDs) can induce severe cutaneous adverse reactions (SCARs) such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. We... -
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- A Simple Dosing Scheme for Intravenous Busulfan Based on Retrospective Population Pharmacokinetic Analysis in Korean Patients
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Choe S, Kim G, Lim HS, Cho SH, Ghim JL, Jung JA, Kim UJ, Noh G, Bae KS, Lee D
- KMID: 2011162
- Korean J Physiol Pharmacol.
- 2012 Aug;16(4):273-280.
- doi: 10.4196/kjpp.2012.16.4.273
Busulfan is an antineoplastic agent with a narrow therapeutic window. A post-hoc population pharmacokinetic analysis of a prospective randomized trial for comparison of four-times daily versus once-daily intravenous busulfan was... -
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