- In Vitro Effect of Liposome-mediated Combined p16 and p53 Gene Transfer to the Human Glioblastoma Cell Lines
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Kim CH, Kwon JT, Min BK, Hwang SN, Hwang DY, Choi DY
- KMID: 1955924
- J Korean Neurosurg Soc.
- 2002 Feb;31(2):152-160.
OBJECTIVE: To overcome the limitations of the single gene transfer, the authors present the results of wild-type p16 and p53 combined genes transfer in vitro to the U251MG and U373MG... -
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- Enhanced Growth inhibition by Combined Gene Transfer of p53 and p16INK4a in Adenoviral Vectors to Lung Cancer Cell Lines
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Choi SH, Park KH, Seol JY, Yoo CG, Lee CT, Kim YW, Han SK, Shim YS
- KMID: 2160057
- Tuberc Respir Dis.
- 2001 Jan;50(1):67-75.
- doi: 10.4046/trd.2001.50.1.67
BACKGROUND: Two tumor suppressor genes, p53 and p16, which have different roles in controlling the cell cycle and inducing apoptosis, are frequently inactivated during carcinogenesis including lung cancer. Single tumor... -
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- Mutation of p53 and p16 Tumor Suppressor Genes in Cancer and Precancerous Lesions of the Gallbladder
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Yoon YB, Kim CY, Kim WH, Kim SW, Kim YT, Ryu JK, Lee WJ
- KMID: 2084961
- Korean J Gastroenterol.
- 1999 Sep;34(3):390-398.
BACKGROUND/AIMS: The purpose of this study was to analyze the frequencies of p53 and p16 gene mutations in gallbladder cancer and precancerous lesions such as dysplasia or adenoma. METHODS: Tissues... -
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- Inactivation Pattern of p16 Gene in Non-Hodgkin's Lymphomas
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Cho HD, Kim IS
- KMID: 1725935
- Korean J Pathol.
- 2002 Dec;36(6):365-373.
BACKGROUND: Loss of heterozygosity (LOH) and mutation of the p16 tumor suppressor gene have been detected in non-Hodgkin's lymphomas (NHLs). Recently, hypermethylation of the p16 gene has been reported. The... -
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- Methylation of P16 and hMLH1 in Gastric Carcinoma
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Sung GY, Chun KH, Kim JJ, Chin HM, Kim W, Park CH, Park SM, Lim KW, Park WB, Kim SN, Jeon HM
- KMID: 2372787
- J Korean Gastric Cancer Assoc.
- 2005 Dec;5(4):228-237.
PURPOSE: We investigated the impacts of the methylation states of the P16 and the hMLH1 genes on pathogenesis and genetic expression of stomach cancer and their relationships with Helicobater pylori... -
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- Methylation Status of CpG Island of p16 in Benign, Atypical and Malignant Meningiomas
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Kim JH, Ahn JS, Jeon SR, Shim YH, Kim CJ, Lee JK
- KMID: 2188848
- J Korean Neurosurg Soc.
- 2003 Feb;33(2):126-131.
OBJECTIVE: Hypermethylation of p16, a tumor suppressor gene, has been frequently detected in a variety of cancer cells and is known to represent the level of p16 transcription. In human... -
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- Disappearance of Serum Methylated p16 Indicates Longer Survival in Patients with Gastric Cancer
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Lim HK, Park JM, Chi KC, Lee EJ, Jeong EM
- KMID: 2372464
- J Gastric Cancer.
- 2013 Sep;13(3):157-163.
PURPOSE: The aim of this study was to assess clinical correlations with postoperative alteration of p16 DNA methylation, and to clarify whether postoperative changes in the serum DNA methylation status... -
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- The Loss of p16(ink4)Expression is Strongly Associated with Hyperme thylation-Related Inactivation in Breast Carcinoma
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Gong G, Kim MJ, Shim YH, Kang GH, Ahn SH, Ro JY
- KMID: 2286624
- J Breast Cancer.
- 2006 Jun;9(2):84-90.
- doi: 10.4048/jbc.2006.9.2.84
PURPOSE: The loss of p16 protein has been frequently detected in breast carcinoma, but genetic alterations are infrequent. CpG islands of methylation within the p16 promotor have been identified as... -
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- Methylation of p16 and E-cadherin in ameloblastoma
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Park CW, Yoon HK, Park SJ
- KMID: 2328581
- J Korean Assoc Oral Maxillofac Surg.
- 2010 Dec;36(6):453-459.
INTRODUCTION: Ameloblastic carcinoma is a rare malignant lesion, and may arise from either carcinoma ex-ameloblastoma or de novo carcinoma. Aberrant promoter hypermethylation of the tumor-associated genes leading to their inactivation... -
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- Clinical Significance of p16 Protein Expression Loss and Aberrant p53 Protein Expression in Pancreatic Cancer
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Jeong J, Park YN, Park JS, Yoon DS, Chi HS, Kim BR
- KMID: 1716522
- Yonsei Med J.
- 2005 Aug;46(4):519-525.
- doi: 10.3349/ymj.2005.46.4.519
Pancreatic cancer is a disease with poor prognosis mainly due to low resection rates and late diagnosis. To increase resectability and improve survival rates, a better understanding of pancreatic cancer... -
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- Association between Promoter Hypermethylation of the p16INK4a and hTERT Genes and Their Protein Expressions in Human Breast Cancer
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Lee SM, Yim HW, Lee A, Park WC, Lee JS, Lee WC
- KMID: 2175002
- J Breast Cancer.
- 2007 Mar;10(1):59-67.
- doi: 10.4048/jbc.2007.10.1.59
PURPOSE: This study was undertaken to observe the pattern of methylation of the p16INK4a and human telomerase reverse transcriptase (hTERT) genes and the p16 and hTERT protein expressions in invasive ductal... -
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- The alteration of p16 protein in invasive cervical cancer
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Ahn SN, Kim WG
- KMID: 2262709
- Korean J Obstet Gynecol.
- 2002 Apr;45(4):602-609.
OBJECTIVE: Recently p16 gene has been found as a new factor for cervical carcinogenesis. The purpose of this study is to investigate the p16 protein alteration in invasive cervical cancers,... -
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- Impact of methylation of the p16INK4a gene on the prognosis ofhead and neck squamous cell carcinoma patients
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Lee EH, Hwang DS, Shin SH, Kim UK, Chung IK, Kim YD
- KMID: 2189706
- J Korean Assoc Oral Maxillofac Surg.
- 2012 Apr;38(2):101-109.
- doi: 10.5125/jkaoms.2012.38.2.101
OBJECTIVES: The inactivation of the tumor suppressor gene p16INK4a plays an important role in the development of malignant tumors, including oral squamous cell carcinoma. The p16 gene is involved in... -
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- p16INK4A and p15 INK4B Gene Alterations in Primary Uterine Cervical Carcinoma Tissues and Cervical Carcinoma Cell Lines
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Yoo SW, Kim JW
- KMID: 2175348
- J Korean Cancer Assoc.
- 1998 Oct;30(5):1044-1052.
PURPOSE: Alterations of the p15(INK4B) and p16(INK4A) gene which are separated by 25 kb on chromosome 9p21 have been reported in various tumor derived cell lines and primary tumors, but... -
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- Immunohistochemical Analysis of Abnormal p16INK4A Protein Expression in Human Breast Cancer
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Song TJ, Moon JS, Lee ES, Lee JB, Choi WJ, Chae GB, Mok YJ, Bae JW, Won NH, Koo BH
- KMID: 2117060
- J Korean Surg Soc.
- 1999 Mar;56(3):326-333.
BACKGROUND: The p16 protein is a cyclin-dependent kinase inhibitor (CDKI) that inhibits cell cycle progression from phase G1 to phase S in the cell cycle. Many p16 gene mutations have... -
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- Genetic Alterations of p16Ink4A and p15Ink4B in Gastric Carcinomas
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Hur K, Yang HK, Jang JJ, Kim JP, Kim DY
- KMID: 2059285
- J Korean Cancer Assoc.
- 1999 Oct;31(5):887-897.
PURPOSE: p16Ink4A and p15lnk4B, encoded by the genes located on chromosome 9p21, are cyclin-dependent kinase 4 inhibitors and are the upstream regulators of pRB (retinoblastoma protein) function and are involved... -
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- Relationship between Methylation Status of p16 Tumor Suppressor Gene and Clinicopathologic Behavior of Stomach Cancer
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Park CW, Lee DH, Kim JY, Seo SB, Ju HJ, Kim GH, Heo J, Kang DH, Cho M, Yang US
- KMID: 2143720
- Korean J Gastroenterol.
- 2002 Jun;39(6):402-408.
BACKGROUND/AIMS: Hypermethylation of the p16 tumor suppressor gene is one of the most widely reported epigenetic event to occur in the development of human cancers. The authors investigated the methylation... -
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- A study on the expression of p16 gene, methylation of p16 gene promoter and HPV typing in uterine cervical neoplasia
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Jeon S, Choi SD, Bae DH, Jeong DJ, Kim CJ, Shin YW
- KMID: 2244549
- Korean J Gynecol Oncol.
- 2007 Sep;18(3):201-208.
OBJECTIVE: p16 is cyclin-dependent kinase (CDK) inhibitor which decelerates cell cycle by inactivating CDKs that phosphorylate retinoblastoma protein (pRb). In cervical carcinogenesis, abnormality of p16 gene such as methylation of... -
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- Methylation of the p16 tumor suppressor gene in Korean patients with colon cancer and adenoma
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Kim DH, Cho M, Kim DH, Joo KR, Park NH, Yang US
- KMID: 2306037
- Korean J Med.
- 2003 Apr;64(4):396-404.
BACKGROUND: De novo methylation and transcriptional silencing of p16 gene is one of the main pathways in inactivation of p16 gene in colon neoplasm. But there has been no study... -
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- Growth Suppression of Human Ovarian Cancer Cells by the Introduction of the p16 Gene Via a Recombinant Adenovirus In Vitro
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Kim TW, Wolf JK, Shin JI, Kim YW, Kim JW, Kim JH, Namkoong S, Kim SJ, Kim SP
- KMID: 2260906
- Korean J Obstet Gynecol.
- 1998 Apr;41(4):978-986.
OBJECTIVE: The cell cycle regulatory p16 protein (the product of the CDKN2A gene also called p16INK4A, CDK4I, and MTS-1) causes cell cycle arrest at the G1 checkpoint by inhibiting activity... -
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