- Loss of the retinoblastoma gene in non-small cell lung cancer
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Lee CT, Kim CM, Zo JI, Shim YM, Hong WS, Lee JO, Kang TW
- KMID: 2049913
- Tuberc Respir Dis.
- 1993 Apr;40(2):98-103.
No abstract available. -
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- Deletion of Rb1 gene in late osteosarcoma from survivor of unilateral retinoblastoma: a case report
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Lee SY, Jeon DG, Lee JS, Hwang CS, Huh K, Lee TW, Hong SI
- KMID: 932138
- J Korean Med Sci.
- 1996 Feb;11(1):94-98.
- doi: 10.3346/jkms.1996.11.1.94
It has been well known that the survivors of retinoblastoma are prone to have osteosarcoma. But the secondary tumor usually occurs in bilateral, hereditary type of retinoblastoma. We report one... -
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- Loss of retinoblastoma gene and amplification of N-myc gene in retinoblastoma
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Choi SW, Lee TW, Yang SW, Hong WS, Kim CM, Lee JO
- KMID: 1421955
- J Korean Med Sci.
- 1993 Feb;8(1):73-77.
- doi: 10.3346/jkms.1993.8.1.73
We have analyzed paired samples of genomic DNA from peripheral leukocyte and primary tumor tissue from nine patients with retinoblastoma (RB) and from two RB cell lines, WERI-Rb-1 and Y79,... -
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- Mutation Analysis of RB1 Gene in Peripheral Blood of Retinoblastoma Patients
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Park JS, Choo YA, Kim DK
- KMID: 1559316
- Korean J Anat.
- 2002 Aug;35(4):335-342.
Retinoblastoma, a child tumor of the eye, is caused by two mutational events at the retinoblastoma gene (RB1). Retinoblastoma occurs in both hereditary and nonhereditary forms, and this distinction has... -
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- Expression of Retinoblastoma Protein in Cutaneous Squamous Cell Carcinomas and Basal Cell Carcinomas
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Cho SY, Ahn HB, Kim DY, Lee SY, Cho BH
- KMID: 2322490
- J Korean Soc Plast Reconstr Surg.
- 1999 Mar;26(2):199-203.
There is increasing evidence that inactivation of tumor-suppressor genes can promote tumor growth. Retinoblastoma protein (pRb) is the product of the retinoblastoma gene located on chromosome 13q14. pRb negatively regulates... -
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- Comparative Analysis of the Expression of p53, Rb, PCNA in thc Gastric Carcinoma
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Lee S, Moon B, Choi SK, Rew CS, Yoon CM, Park CS
- KMID: 2080536
- Korean J Med.
- 1997 Jun;52(6):846-857.
OBJECTIVES: Recently, the studies for oncogene and tumor marker have been actively performed to investigate the carcinogenesis of gastric carcinoma, but it is not clearly understood. We investigated the expression... -
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- Treatment of Retinoblastoma: The Role of External Beam Radiotherapy
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Kim JY, Park Y
- KMID: 2345873
- Yonsei Med J.
- 2015 Nov;56(6):1478-1491.
- doi: 10.3349/ymj.2015.56.6.1478
The risk of radiotherapy-related secondary cancers in children with constitutional retinoblastoma 1 (RB1) mutations has led to reduced use of external beam radiotherapy (EBRT) for RB. Presently, tumor reduction with... -
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- The Genetic Alterations of Retinoblastoma Gene in Human Gliomas
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Rhee CH, Lee SH, Kim MS, Park SY, Hong SI, Han DH
- KMID: 2018958
- J Korean Neurosurg Soc.
- 1996 Nov;25(11):2165-2172.
The formation and malignant progression of gliomas are generally considered to undergo multistepped process like other tumors. Loss of 13q is implicated in the later stage of progression of gliomas.... -
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- A Study on Expression Pattern of p53, Rb Gene and Apoptosis in Ovarian Epithelial Borderline Tumors and Invasive Carcinoma
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Ha MW, Ko HK, Kang GJ, Yoon MS, Sol MY
- KMID: 2269976
- Korean J Obstet Gynecol.
- 2000 Mar;43(3):407-413.
OBJECTIVE: The aim of this study is to evaluate the role of tumor suppressor genes, p53 and Rb gene, as well as apoptosis in the carcinogenesis of ovarian epithelial tumors.... -
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- An Immunohistochemical Study of p53 and RB Protein Expression in Normal Cervical Tissue, Cervical Intraepithelial Neoplasia and Invasive Cervical Carcinoma
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Lee C, Sunwoo TW, Ahn HJ
- KMID: 2261142
- Korean J Obstet Gynecol.
- 1998 Sep;41(9):2295-2303.
Carcinoma of the uterine cervix is the most common malignant tumor in Korean women. It is well known that carcinogenesis is a multi-step event involoving the inactivation of tumor supressor... -
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- Impact of methylation of the p16INK4a gene on the prognosis ofhead and neck squamous cell carcinoma patients
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Lee EH, Hwang DS, Shin SH, Kim UK, Chung IK, Kim YD
- KMID: 2189706
- J Korean Assoc Oral Maxillofac Surg.
- 2012 Apr;38(2):101-109.
- doi: 10.5125/jkaoms.2012.38.2.101
OBJECTIVES: The inactivation of the tumor suppressor gene p16INK4a plays an important role in the development of malignant tumors, including oral squamous cell carcinoma. The p16 gene is involved in... -
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- Clinical significance of molecular genetic changes in sporadic invasive pituitary adenomas
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Nam DH, Song SY, Park KS, Kim MH, Suh YL, Lee JI, Kim JS, Hong SC, Shin HJ, Park K, Eoh W, Kim JH
- KMID: 938873
- Exp Mol Med.
- 2001 Sep;33(3):111-116.
Several molecular and genetic changes have been found in pituitary adenomas. We looked for correlations between these changes and the degree of invasiveness of the tumors. The invasiveness of 11... -
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- DNA Ploidy and Mutant p53 and Rb Gene Expression in the Ovarian Tumors
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Kim YW, Ku PS, Kim IS
- KMID: 2115534
- Korean J Obstet Gynecol.
- 1997 Dec;40(12):2717-2727.
No abstract available. -
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- The Molecular Biologic Study about the Role of Deubiquitination Gene in Bladder Tumor Progression
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Kim HY, Lee YG, Lee SE
- KMID: 2292517
- Korean J Urol.
- 2002 Dec;43(12):1019-1023.
PURPOSE: Ubiqutin-proteasome-mediated proteolysis is an important pathway of nonlysosomal protein degradation, which controls the timed destruction of cellular regulatory proteins of the p21, p27, p53 gene (p53), Retinoblastoma gene (Rb),... -
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- The Roles of P53, Rb and Ki-67 LI on Bladder Tumor
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Lee HL, Kim TW, Lee SC, Kim YT, Kim WJ
- KMID: 2289906
- Korean J Urol.
- 1999 Sep;40(9):1111-1118.
PURPOSE: This study was performed to evaluate whether the overexpression of p53 and Ki-67, and loss or overexpression of Rb were associated with clinical parameters of bladder tumor. MATERIALS AND METHODS:... -
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- Loss of heterozygosity on chromosome 10, 13q(Rb), 17p, and p53 gene mutations in human brain gliomas
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Lee SH, Kim JH, Rhee CH, Kang YS, Lee JH, Hong SI, Choi KS
- KMID: 927177
- J Korean Med Sci.
- 1995 Dec;10(6):442-448.
- doi: 10.3346/jkms.1995.10.6.442
Using the methods of restriction fragment length polymorphism (RFLP) and single strand conformation polymorphism (SSCP) analyses, we have examined 33 cases of human gliomas with various malignant grades to detect... -
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- Prognostic Role of Rb, p16, Cyclin D1 Proteins in Soft Tissue Sarcomas
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Shim BY, Yoo J, Lee YS, Hong YS, Kim HK, Kang JH
- KMID: 2270803
- Cancer Res Treat.
- 2010 Sep;42(3):144-150.
PURPOSE: The aim of this study was to determine the expressions of Rb, p16, and cyclin D1 in soft tissue sarcomas, and we also wanted to identify the prognostic factors... -
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- Analysis of p53 and Retinoblasoma(Rb) Gene Polymorphisms in Relation to Lung Cancer in Koreans
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Lee KS, Sohn JW, Yang SC, Yoon HJ, Shin DH, Park SS, Lee JH, Lee CG, Cho YH
- KMID: 2318033
- Tuberc Respir Dis.
- 1997 Jun;44(3):534-546.
BACKGROUND: The p53 and retinoblastoma(Rb) tumor suppressor genes are associated with the pathogenesis of several types of human cancer. Substantial. proportion of the primary lung cancers or cell lines have... -
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- The Correlation between the Expression of CD99 and the Cell Cycle
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Yu CS, Chang MC, Oh SK
- KMID: 2145187
- J Korean Surg Soc.
- 2001 Oct;61(4):347-356.
PURPOSE: The cell cycle control system is necessary for the normal growth and differentiation of cells. The purposes of this study were to compare CD99 expression with a known... -
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- Loss of Heterozygosity of Major Tumor Suppressor Genes in Invasive Ductal Carcinomas
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Byun WS, Park CH, Cho SJ, Ahn HG, Nam ES, Cha HJ, Kim KS
- KMID: 2175003
- J Breast Cancer.
- 2007 Mar;10(1):68-76.
- doi: 10.4048/jbc.2007.10.1.68
PURPOSE: Breast cancer is one of the most frequent malignant tumors in Korea. The major tumor suppressor genes (TSGs) such as p16, Rb, E-cadherin and p53 may play important roles... -
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