- Review of Biological Network Data and Its Applications
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Yu D, Kim M, Xiao G, Hwang TH
- KMID: 2166503
- Genomics Inform.
- 2013 Dec;11(4):200-210.
- doi: 10.5808/GI.2013.11.4.200
Studying biological networks, such as protein-protein interactions, is key to understanding complex biological activities. Various types of large-scale biological datasets have been collected and analyzed with high-throughput technologies, including DNA... -
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- PromoterWizard: An Integrated Promoter Prediction Program Using Hybrid Methods
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Park K, Kim KB
- KMID: 2053276
- Genomics Inform.
- 2011 Dec;9(4):194-196.
Promoter prediction is a very important problem and is closely related to the main problems of bioinformatics such as the construction of gene regulatory networks and gene function annotation. In... -
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- Gene Regulatory Network Analysis for Triple-Negative Breast Neoplasms by Using Gene Expression Data
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Jung HC, Kim SH, Lee JH, Kim JH, Han SW
- KMID: 2438990
- J Breast Cancer.
- 2017 Sep;20(3):240-245.
- doi: 10.4048/jbc.2017.20.3.240
PURPOSE: To better identify the physiology of triple-negative breast neoplasm (TNBN), we analyzed the TNBN gene regulatory network using gene expression data. METHODS: We collected TNBN gene expression data from The... -
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- Directed Causal Network Construction Using Linkage Analysis with Metabolic Syndrome-Related Expression Quantitative Traits
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Kim KZ, Min JY, Kwon GY, Sung J, Cho SI
- KMID: 2053270
- Genomics Inform.
- 2011 Dec;9(4):143-151.
In this study, we propose a novel, intuitive method of constructing an expression quantitative trait (eQT) network that is related to the metabolic syndrome using LOD scores and peak loci... -
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- Drug Similarity Search Based on Combined Signatures in Gene Expression Profiles
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Cha K, Kim MS, Oh K, Shin H, Yi GS
- KMID: 2166739
- Healthc Inform Res.
- 2014 Jan;20(1):52-60.
- doi: 10.4258/hir.2014.20.1.52
OBJECTIVES: Recently, comparison of drug responses on gene expression has been a major approach to identifying the functional similarity of drugs. Previous studies have mostly focused on a single feature,... -
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- Analysis of Gene Expression in Mouse Spinal Cord-derived Neural Precursor Cells During Neuronal Differentiation
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Ahn JI, Kim SY, Ko MJ, Chung HJ, Jeong HS
- KMID: 2053227
- Genomics Inform.
- 2009 Jun;7(2):85-96.
The differentiation of neural precursor cells (NPCs) into neurons and astrocytes is a process that is tightly controlled by complicated and ill-defined gene networks. To extend our knowledge to gene... -
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- Differential Tissue-specific and Pathway-specific Anti-obesity Effects of Green Tea and Taeumjowitang, a Traditional Korean Medicine, in Mice
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Kim J, Park S, An H, Choi JY, Choi MS, Choi SW, Kim SJ
- KMID: 2396163
- J Cancer Prev.
- 2017 Sep;22(3):147-158.
- doi: 10.15430/JCP.2017.22.3.147
BACKGROUND: Traditional medicines have been leveraged for the treatment and prevention of obesity, one of the fastest growing diseases in the world. However, the exact mechanisms underlying the effects of... -
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- StrokeBase: A Database of Cerebrovascular Disease-related Candidate Genes
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Kim YU, Kim IH, Bang OS, Kim YJ
- KMID: 2166413
- Genomics Inform.
- 2008 Sep;6(3):153-156.
Complex diseases such as stroke and cancer have two or more genetic loci and are affected by environmental factors that contribute to the diseases. Due to the complex characteristics of... -
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- Genome Engineering for Osteoarthritis: From Designer Cells to Disease-Modifying Drugs
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Choi YR, Collins KH, Lee JW, Kang HJ, Guilak F
- KMID: 2455043
- Tissue Eng Regen Med.
- 2019 Aug;16(4):335-343.
- doi: 10.1007/s13770-018-0172-4
BACKGROUND: Osteoarthritis (OA) is a highly prevalent degenerative joint disease involving joint cartilage and its surrounding tissues. OA is the leading cause of pain and disability worldwide. At present, there... -
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- Expressional Subpopulation of Cancers Determined by G64, a Co-regulated Module
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Min JW, Choi SS
- KMID: 2166528
- Genomics Inform.
- 2015 Dec;13(4):132-136.
- doi: 10.5808/GI.2015.13.4.132
Studies of cancer heterogeneity have received considerable attention recently, because the presence or absence of resistant sub-clones may determine whether or not certain therapeutic treatments are effective. Previously, we have... -
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- Transcriptional Network Controlling Endochondral Ossification
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Hata K, Takahata Y, Murakami T, Nishimura
- KMID: 2379988
- J Bone Metab.
- 2017 May;24(2):75-82.
- doi: 10.11005/jbm.2017.24.2.75
Endochondral ossification is the fundamental process of skeletal development in vertebrates. Chondrocytes undergo sequential steps of differentiation, including mesenchymal condensation, proliferation, hypertrophy, and mineralization. These steps, which are required for... -
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- Identification of Molecular Signatures in Mild Intrinsic Atopic Dermatitis by Bioinformatics Analysis
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Yin H, Wang S, Gu C
- KMID: 2471339
- Ann Dermatol.
- 2020 Apr;32(2):130-140.
- doi: 10.5021/ad.2020.32.2.130
BACKGROUND: Atopic dermatitis (AD) is recognized as a common inflammatory skin disease and frequently occurred in Asian and Black individuals. OBJECTIVE: Since the limitation of dataset associated with human severe AD,... -
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- Bioinformatic identification of prognostic signature defined by copy number alteration and expression of CCNE1 in non-muscle invasive bladder cancer
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Song BN, Kim SK, Chu IS
- KMID: 2367528
- Exp Mol Med.
- 2017 Jan;49(1):e282.
- doi: 10.1038/emm.2016.120
Non-muscle invasive bladder cancer (NMIBC) patients frequently fail to respond to treatment and experience disease progression because of their clinical and biological diversity. In this study, we identify a prognostic... -
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- A Gene and Neural Stem Cell Therapy Platform Based on Neuronal Cell Type-Inducible Gene Overexpression
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Oh J, You Y, Yun Y, Lee HL, Yoon DH, Lee M, Ha Y
- KMID: 2366346
- Yonsei Med J.
- 2015 Jul;56(4):1036-1043.
- doi: 10.3349/ymj.2015.56.4.1036
PURPOSE: Spinal cord injury (SCI) is associated with permanent neurological damage, and treatment thereof with a single modality often does not provide sufficient therapeutic outcomes. Therefore, a strategy that combines... -
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- Integrative epigenomic and genomic analysis of malignant pheochromocytoma
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Sandgren J, Andersson , Rada-Iglesias A, Enroth S, Akerstrom , Dumanski J, Komorowski J, Westin G, Wadelius C
- KMID: 1104209
- Exp Mol Med.
- 2010 Jul;42(7):484-502.
- doi: 10.3858/emm.2010.42.7.050
Epigenomic and genomic changes affect gene expression and contribute to tumor development. The histone modifications trimethylated histone H3 lysine 4 (H3K4me3) and lysine 27 (H3K27me3) are epigenetic regulators associated to... -
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- Differentiated miRNA expression and validation of signaling pathways in apoE gene knockout mice by cross-verification microarray platform
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Han H, Wang YH, Qu GJ, Sun TT, Li FQ, Jiang W, Luo SS
- KMID: 2154232
- Exp Mol Med.
- 2013 Mar;45(3):e13.
The microRNA (miRNA) regulation mechanisms associated with atherosclerosis are largely undocumented. Specific selection and efficient validation of miRNA regulation pathways involved in atherosclerosis development may be better assessed by contemporary... -
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- Differential expression of thymic DNA repair genes in low-dose-rate irradiated AKR/J mice
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Bong JJ, Kang YM, Shin SC, Choi SJ, Lee KM, Kim HS
- KMID: 1705557
- J Vet Sci.
- 2013 Sep;14(3):271-279.
- doi: 10.4142/jvs.2013.14.3.271
We previously determined that AKR/J mice housed in a low-dose-rate (LDR) (137Cs, 0.7 mGy/h, 2.1 Gy) gamma-irradiation facility developed less spontaneous thymic lymphoma and survived longer than those receiving sham... -
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- beta1-integrin-dependent migration of microglia in response to neuron-released alpha-synuclein
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Kim C, Cho ED, Kim HK, You S, Lee HJ, Hwang D, Lee SJ
- KMID: 2155356
- Exp Mol Med.
- 2014 Apr;46(4):e91.
- doi: 10.1038/emm.2014.6
Chronic neuroinflammation is an integral pathological feature of major neurodegenerative diseases. The recruitment of microglia to affected brain regions and the activation of these cells are the major events leading... -
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