- Suppression of ROS generation by 4,4'-diaminodiphenylsulfone in non-phagocytic human diploid fibroblasts
-
Cho SC, Rhim JH, Son YH, Lee SJ, Park SC
- KMID: 946655
- Exp Mol Med.
- 2010 Mar;42(3):223-232.
- doi: 10.3858/emm.2010.42.3.024
The action mode of 4,4'-diaminodiphenylsulfone (DDS) is still under debate, although it has long been used in treatment of several dermatologic diseases including Hansen's disease. In this study, we tested... -
- CITED
-
- Close
- SHARE
-
- Close
- Expression of hOGG1 protein during differentiation of HL-60 cells
-
Lee YS, Lee KH, Chung MH
- KMID: 1097257
- Exp Mol Med.
- 2003 Apr;35(2):98-105.
Human 8-oxo-G-DNA glycosylase 1 (hOGG1) is a DNA glycosylase to cleave 8-oxo-7,8-dihydroguanine (8-oxo-G), a mutagenic DNA adduct formed by oxidant stresses. Here, we examined hOGG1 protein expression and repair activity... -
- CITED
-
- Close
- SHARE
-
- Close
- Effect of ceramide on apoptosis and phospholipase D activity in FRTL-5 thyroid cells
-
Park BJ, Kim JH, Han JS, Jung PM
- KMID: 755043
- Exp Mol Med.
- 1999 Sep;31(3):142-150.
Ceramide, a product of sphingomyelin hydrolysis, is now recognized as an intracellular lipid messenger, which mediates the effects of extracellular agents on cellular growth, differentiation and apoptosis. Recently, ceramide has been implicated in... -
- CITED
-
- Close
- SHARE
-
- Close
- Triptolide inhibits ovarian cancer cell invasion by repression of matrix metalloproteinase 7 and 19 and upregulation of E-cadherin
-
Zhao H, Yang Z, Wang X, Zhang X, Wang M, Wang Y, Mei Q, Wang Z
- KMID: 1401755
- Exp Mol Med.
- 2012 Nov;44(11):633-641.
Triptolide, a compound extracted from the traditional Chinese medicine preparation of Tripterygium wilfordii Hook F., has been reported to have anti-inflammatory and anti-cancer activities. However, its effect on ovarian cancer... -
- CITED
-
- Close
- SHARE
-
- Close
- The Ketogenic Diet Suppresses the Cathepsin E Expression Induced by Kainic Acid in the Rat Brain
-
Jeong HJ, Kim H, Kim YK, Park SK, Kang DW, Yoon D
- KMID: 1071415
- Yonsei Med J.
- 2010 Sep;51(5):653-660.
- doi: 10.3349/ymj.2010.51.5.653
PURPOSE: The ketogenic diet has long been used to treat epilepsy, but its mechanism is not yet clearly understood. To explore the potential mechanism, we analyzed the changes in gene... -
- CITED
-
- Close
- SHARE
-
- Close
- Role of phospholipase D1 in glucose-induced insulin secretion in pancreatic beta cells
-
Ma WN, Park SY, Han JS
- KMID: 1078361
- Exp Mol Med.
- 2010 Jun;42(6):456-464.
- doi: 10.3858/emm.2010.42.6.047
As glucose is known to induce insulin secretion in pancreatic beta cells, this study investigated the role of a phospholipase D (PLD)-related signaling pathway in insulin secretion caused by high... -
- CITED
-
- Close
- SHARE
-
- Close
- Epigallocatechin-3-gallate Suppresses Galactose-alpha1,4-galactose-beta1,4-glucose Ceramide Expression in TNF-alpha Stimulated Human Intestinal Epithelial Cells Through Inhibition of MAPKs and NF-kappa B
-
Moon DO, Choi SR, Lee CM, Kim GY, Lee HJ, Park YM
- KMID: 1712731
- J Korean Med Sci.
- 2005 Aug;20(4):548-554.
- doi: 10.3346/jkms.2005.20.4.548
Intestinal epithelial cells (IECs) have been known to produce galactose-alpha1,4-galactose-beta1,4-glucose ceramide (Gb3) that play an important role in the mucosal immune response. The regulation of Gb3 is important to prevent... -
- CITED
-
- Close
- SHARE
-
- Close
- Curcumin reduces cold storage-induced damage in human cardiac myoblasts
-
Abuarqoub , Green CJ, Foresti R, Motterlini R
- KMID: 1094654
- Exp Mol Med.
- 2007 Apr;39(2):139-148.
Curcumin is a polyphenolic compound possessing interesting anti-inflammatory and antioxidant properties and has the ability to induce the defensive protein heme oxygenase-1 (HO-1). The objective of this study was to... -
- CITED
-
- Close
- SHARE
-
- Close
- The inhibitory effect of quercitrin gallate on iNOS expression induced by lipopolysaccharide in Balb/c mice
-
Jo HY, Kim Y, Nam SY, Lee BJ, Kim YB, Yun YW, Ahn B
- KMID: 1718579
- J Vet Sci.
- 2008 Sep;9(3):267-272.
- doi: 10.4142/jvs.2008.9.3.267
Quercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside (QGR) is a naturally occurring quercitrin gallate, which is a polyphenolic compound that was originally isolated from Persicaria lapathifolia (Polygonaceae). QGR has been shown to have an inhibitory... -
- CITED
-
- Close
- SHARE
-
- Close
- Antiobesity activity of a sphingosine 1-phosphate analogue FTY720 observed in adipocytes and obese mouse model
-
Moon MH, Jeong JK, Lee JH, Park YG, Lee YJ, Seol JW, Park SY
- KMID: 1506224
- Exp Mol Med.
- 2012 Oct;44(10):603-614.
Higher levels of body fat are associated with an increased risk for development numerous adverse health conditions. FTY720 is an immune modulator and a synthetic analogue of sphingosine 1-phosphate (S1P),... -
- CITED
-
- Close
- SHARE
-
- Close
- Anti-apoptotic role of phospholipase D isozymes in the glutamate-induced cell death
-
Kim KO, Lee KH, Kim YH, Park SK, Han JS
- KMID: 1088656
- Exp Mol Med.
- 2003 Feb;35(1):38-45.
Abstract Phospholipase D (PLD) plays an important role as an effector in a variety of physiological processes that reveal it to be a member of the signal transducing phospholipases. Recently,... -
- CITED
-
- Close
- SHARE
-
- Close
- Celastrol inhibits production of nitric oxideandproinflammatory cytokines through MAPK signal transduction and NF-kappaB in LPS-stimulated BV-2 microglial cells
-
Jung HW, Chung YS, Kim YS, Park YK
- KMID: 1091066
- Exp Mol Med.
- 2007 Dec;39(6):715-721.
Excessive production of nitric oxide (NO) and proinflammatory cytokines from activated microglia play an important role in human neurodegenerative disorders. Here, we investigated whether celastrol, which has been used as... -
- CITED
-
- Close
- SHARE
-
- Close
- Acetyl-CoA carboxylase beta expression mediated by MyoD and muscle regulatory factor 4 is differentially affected by retinoic acid receptor and retinoid X receptor
-
Kim JY, Lee JJ, Kim KS
- KMID: 1088654
- Exp Mol Med.
- 2003 Feb;35(1):23-29.
Mammals have two major isoforms of acetyl-CoA carboxyase (ACC). The 275 kDa beta-form (ACC beta) is predominantly in heart and skeletal muscle while the 265 kDa alpha-form (ACC alpha) is... -
- CITED
-
- Close
- SHARE
-
- Close
- Inhibition of acyl-coenzyme A:cholesterol acyltransferase stimulates cholesterol efflux from macrophages and stimulates farnesoid X receptor in hepatocytes
-
An S, Jang YS, Park JS, Kwon BM, Paik YK, Jeong TS
- KMID: 1094120
- Exp Mol Med.
- 2008 Aug;40(4):407-417.
- doi: 10.3858/emm.2008.40.4.407
We investigated the mechanism of spontaneous cholesterol efflux induced by acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibition, and how an alteration of cholesterol metabolism in macrophages impacts on that in HepG2 cells.... -
- CITED
-
- Close
- SHARE
-
- Close
- Coptidis rhizoma extract protects against cytokine-induced death of pancreatic beta-cells through suppression of NF-kappa B activation
-
Kim EK, Kwon KB, Han MJ, Song MY, Lee JH, Lv N, Ka SO, Yeom SR, Kwon YD, Ryu DG, Kim KS, Park JW, Park R, Park BH
- KMID: 1094655
- Exp Mol Med.
- 2007 Apr;39(2):149-159.
We demonstrated previously that Coptidis rhizoma extract (CRE) prevented S-nitroso-N-acetylpenicillamine-induced apoptotic cell death via the inhibition of mitochondrial membrane potential disruption and cytochrome c release in RINm5F (RIN) rat insulinoma... -
- CITED
-
- Close
- SHARE
-
- Close
- Soluble factor from tumor cells induces heme oxygenase-1 by a nitric oxide-independent mechanism in murine peritoneal macrophages
-
Kim SW, Oh HM, Kim BS, Chung HT, Han WC, Kim EC, Kim TH, Seo GS, Lyou JH, Nah YH, Jung JC, Choi SC, Jun CD
- KMID: 1088658
- Exp Mol Med.
- 2003 Feb;35(1):53-59.
Tumor target-derived soluble secretary factor has been known to influence macrophage activation to induce nitric oxide (NO) production. Since heme oxigenase-1 (HO-1) is induced by a variety of conditions associated... -
- CITED
-
- Close
- SHARE
-
- Close
