- Effects of Benzo[a]pyrene, 2-Bromopropane, Phenol and 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on Proinflammatory Cytokines Gene Expression by Mice Spleen Cells
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Kim HJ, Kang BN, Cho SW, Son HY, Jeong KS, Park SJ, Kim SH, Kim SR, Kim TH, An MY, Ryu SY
- KMID: 1097340
- J Vet Sci.
- 2002 Dec;3(4):247-254.
The detrimental effects of environmental pollutants on the health of the individual are generally accepted, although the mechanisms of these effects remain to be incompletely understood. In the present study,... -
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- Apoptosis, bcl2 expression, and cell cycle analyses in nickel(II)-treated normal rat kidney cells
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Lee SH, Choi JG, Cho MH
- KMID: 648251
- J Korean Med Sci.
- 2001 Apr;16(2):165-168.
- doi: 10.3346/jkms.2001.16.2.165
Nickel compounds are carcinogenic to human and are potent inducers of kidney and lung tumors in experimental animals. In this study, the effects of nickel(II) acetate on apoptosis, cell cycle... -
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- Alterations in antioxidant function and cell apoptosis in duck spleen exposed to molybdenum and/or cadmium
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Zhang M, Luo J, Zhang C, Cao H, Xia B, Hu G
- KMID: 2412572
- J Vet Sci.
- 2017 Jun;18(2):193-200.
- doi: 10.4142/jvs.2017.18.2.193
To investigate the effects of molybdenum (Mo) and/or cadmium (Cd) on antioxidant function and the apoptosis-related genes in duck spleens. Sixty healthy 11-day-old ducks were randomly divided into six groups... -
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- Rolipram, a Phosphodiesterase 4 Inhibitor, Stimulates Inducible cAMP Early Repressor Expression in Osteoblasts
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Cho ES, Yu JH, Kim MS, Yim M
- KMID: 2158125
- Yonsei Med J.
- 2005 Feb;46(1):149-154.
- doi: 10.3349/ymj.2005.46.1.149
Phosphodiesterase (PDE) 4 inhibitors have been shown to induce the cAMP-mediated signaling pathway by inhibiting cAMP hydrolysis. This study investigated the effect of a PDE4 inhibitor on the expression of... -
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- Development of an angiogenesis-focused cDNA chip and validation of its functionality
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Shim JS, Lee HK, Park HM, Kim JO, Kim EK, Hwang KH, Kim KT, Park SW, Lee JH, Kwon HJ
- KMID: 1093471
- Exp Mol Med.
- 2005 Aug;37(4):365-370.
DNA chip has been used as a powerful tool to study the genetic reprogramming of cells and its link to cellular phenotype such as angiogenesis. To evaluate the angiogenesis related... -
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- Kurarinone promotes TRAIL-induced apoptosis by inhibiting NF-kappaB-dependent cFLIP expression in HeLa cells
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Seo OW, Kim JH, Lee KS, Lee KS, Kim JH, Won MH, Ha KS, Kwon YG, Kim YM
- KMID: 1401757
- Exp Mol Med.
- 2012 Nov;44(11):653-664.
This study was designed to investigate the effects of the prenylated flavonoid kurarinone on TNF-related apoptosis inducing ligand (TRAIL)-induced apoptosis and its underlying mechanism. A low dose of kurarinone had... -
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- Tanshinone IIA inhibits osteoclast differentiation through down-regulation of c-Fos and NFATc1
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Kwak HB, Yang D, Ha H, Lee JH, Kim HN, Woo ER, Lee S, Kim HH, Lee ZH
- KMID: 1094151
- Exp Mol Med.
- 2006 Jun;38(3):256-264.
Bone is a dynamic tissue that is regulated by the activity of bone-resorbing osteoclasts and bone-forming osteoblasts. Excessive osteoclast formation causes diseases such as osteoporosis and rheumatoid arthritis. Natural substances... -
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- Netrin Inhibits Regenerative Axon Growth of Adult Dorsal Root Ganglion Neurons in Vitro
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Park JI, Seo IA, Lee HK, Park HT, Shin SW, Park YM, Ahn KJ
- KMID: 1127079
- J Korean Med Sci.
- 2007 Aug;22(4):641-645.
- doi: 10.3346/jkms.2007.22.4.641
Netrin is a neuronal guidance molecule implicated in the development of spinal commissural neurons and cortical neurons. The attractive function of netrin requires the receptor, Deleted in Colorectal Cancer (DCC),... -
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- Parthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in an in vivo rat model
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Kim IH, Kim SW, Kim SH, Lee SO, Lee ST, Kim DG, Lee MJ, Park WH
- KMID: 1397449
- Exp Mol Med.
- 2012 Jul;44(7):448-456.
Parthenolide (PT), a sesquiterpene lactone derived from the plant feverfew, has pro-apoptotic activity in a number of cancer cell types. We assessed whether PT induces the apoptosis of hepatic stellate... -
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- Bee venom stimulates human melanocyte proliferation, melanogenesis, dendricity and migration
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Jeon S, Kim NH, Koo BS, Lee HJ, Lee AY
- KMID: 1090963
- Exp Mol Med.
- 2007 Oct;39(5):603-613.
Pigmentation may result from melanocyte proliferation, melanogenesis, migration or increases in dendricity. Recently, it has been reported that secreted phospholipase A2(sPLA2) known as a component of bee venom (BV), stimulates... -
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- IL-4 inhibits proliferation of renal carcinoma cells by increasing the expression of p21WAF1 and IRF-1
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Yu SJ, Kim HS, Cho SW, Sohn J
- KMID: 1094082
- Exp Mol Med.
- 2004 Aug;36(4):372-379.
Interleukin (IL)-4 inhibits proliferation of several human cancer cell lines in vitro. Although IL-4 is known to regulate proliferation of lymphocytes by modulating p27KIP1 expression, the mechanism involved in the... -
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- Combinational Treatment with Retinoic Acid Derivatives in Non-small Cell Lung Carcinoma In Vitro
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Choi EJ, Whang YM, Kim SJ, Kim HJ, Kim YH
- KMID: 1785789
- J Korean Med Sci.
- 2007 Sep;22(Suppl):S52-S60.
- doi: 10.3346/jkms.2007.22.S.S52
The growth inhibitory effects of four retinoic acid (RA) derivatives, 9-cis RA, 13-cis RA, N-(4-hydroxyphenyl) retinamide (4-HPR), and all-trans retinoic acid (ATRA) were compared. In addition, the effects of various... -
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- Apical acidity decreases inhibitory effect of omeprazole on Mg2+ absorption and claudin-7 and -12 expression in Caco-2 monolayers
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Thongon N, Krishnamra N
- KMID: 1401760
- Exp Mol Med.
- 2012 Nov;44(11):684-693.
Clinical studies reported hypomagnesaemia in long-term omeprazole usage that was probably due to intestinal Mg2+ wasting. Our previous report demonstrated the inhibitory effect of omeprazole on passive Mg2+ transport across... -
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- Regulation of Glomerular Endothelial Cell Proteoglycans by Glucose
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Ha TS, Duraisamy , Faulkner J, Kasinath B
- KMID: 1733484
- J Korean Med Sci.
- 2004 Apr;19(2):245-252.
- doi: 10.3346/jkms.2004.19.2.245
The presence of heparan sulfate proteoglycan (HSPG) in anionic sites in the lamina rara interna of glomerular basement membrane suggests that the proteoglycan may be deposited by the glomerular endothelial... -
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- The Effect of Simvastatin on the Proliferation and Differentiation of Human Bone Marrow Stromal Cells
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Baek KH, Lee WY, Oh KW, Tae HJ, Lee JM, Lee EJ, Han JH, Kang MI, Cha BY, Lee KW, Son HY, Kang SK
- KMID: 1778503
- J Korean Med Sci.
- 2005 Jun;20(3):438-444.
- doi: 10.3346/jkms.2005.20.3.438
Statins have been postulated to affect the bone metabolism. Recent experimental and epidemiologic studies have suggested that statins may also have bone protective effects. This study assessed the effects of... -
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- An antioxidant modulates expression of receptor activator of NF-kappaB in asthma
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Lee KS, Park HS, Park SJ, Kim SR, Min KH, Jin SM, Li L, Lee YC
- KMID: 1094147
- Exp Mol Med.
- 2006 Jun;38(3):217-229.
Oxidative stress plays critical roles in airway inflammation that is usually accompanied by increased vascular permeability and plasma exudation. VEGF increases vascular permeability and leads to airway inflammation. In addition,... -
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- The Protective Effect of Sodium Hyaluronate on the Cartilage of Rabbit Osteoarthritis by Inhibiting Peroxisome Proliferator-Activated Receptor-Gamma Messenger RNA Expression
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Zhou JL, Liu SQ, Qiu B, Hu QJ, Ming JH, Peng H
- KMID: 1777099
- Yonsei Med J.
- 2009 Dec;50(6):832-837.
- doi: 10.3349/ymj.2009.50.6.832
PURPOSE: The purpose of this study was to study the protective effect and influence of sodium hyaluronate (Na-HA) on mRNA expression of peroxisome proliferators-activated receptor gamma (PPAR-gamma) in cartilage of... -
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- LYR71, a derivative of trimeric resveratrol, inhibits tumorigenesis by blocking STAT3-mediated matrix metalloproteinase 9 expression
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Kim JE, Kim HS, Shin YJ, Lee CS, Won C, Lee SA, Lee JW, Kim Y, Kang JS, Ye SK, Chung MH
- KMID: 1104805
- Exp Mol Med.
- 2008 Oct;40(5):514-522.
- doi: 10.3858/emm.2008.40.5.514
Tumor migration/invasion is the main cause of tumor progression and STAT3 is needed to enhance tumor migration/invasion by up-regulating MMP-9. Thus, agents that inhibit STAT3 activation may be used as... -
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- Transdifferentiation of Cultured Bovine Lens Epithelial Cells into Myofibroblast-like Cells by Serum Modulation
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Kim JT, Lee EH, Chung KH, Kang IC, Lee DH, Joo CK
- KMID: 1734118
- Yonsei Med J.
- 2004 Jun;45(3):380-391.
- doi: 10.3349/ymj.2004.45.3.380
An after-cataract is caused by the proliferation of residual cells over the equator of the lens. These cells subsequently migrate to the posterior lens capsule, where they undergo aberrant differentiation... -
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- Anti-obesity effects of Lysimachia foenum-graecum characterized by decreased adipogenesis and regulated lipid metabolism
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Seo JB, Choe SS, Jeong HW, Park SW, Shin HJ, Choi SM, Park JY, Choi EW, Kim JB, Seen DS, Jeong JY, Lee TG
- KMID: 1104390
- Exp Mol Med.
- 2011 Apr;43(4):205-215.
- doi: 10.3858/emm.2011.43.4.025
Lysimachia foenum-graecum has been used as an oriental medicine with anti-inflammatory effect. The anti-obesity effect of L. foenum-graecum extract (LFE) was first discovered in our screening of natural product extract... -
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