- Small GTPases and formins in mammalian oocyte maturation: cytoskeletal organizers
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Kwon S, Lim HJ
- KMID: 1805481
- Clin Exp Reprod Med.
- 2011 Mar;38(1):1-5.
- doi: 10.5653/cerm.2011.38.1.1
The maturation process of mammalian oocytes accompanies an extensive rearrangement of the cytoskeleton and associated proteins. As this process requires a delicate interplay between the cytoskeleton and its regulators, it... -
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- Rap Signaling in Normal Lymphocyte Development and Leukemia Genesis
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Minato N
- KMID: 1474592
- Immune Netw.
- 2009 Apr;9(2):35-40.
- doi: 10.4110/in.2009.9.2.35
Although Rap GTPases of the Ras family remained enigmatic for years, extensive studies in this decade have revealed diverse functions of Rap signaling in the control of cell proliferation, differentiation,... -
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- Regulation of GTP-binding state in RalA through Ca2+ and calmodulin
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Park JB
- KMID: 755118
- Exp Mol Med.
- 2001 Mar;33(1):54-58.
RalA GTPase, a member of Ras superfamily proteins, shows alternative forms between the active GTP-binding and the inactive GDP-binding states. Ral-specific guanine nucleotide exchange factor such as RalGDS interacts with... -
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- Role of Regulators of G-Protein Signaling 4 in Ca2+ Signaling in Mouse Pancreatic Acinar Cells
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Park S, Lee SI, Shin DM
- KMID: 2285425
- Korean J Physiol Pharmacol.
- 2011 Dec;15(6):383-388.
- doi: 10.4196/kjpp.2011.15.6.383
Regulators of G-protein signaling (RGS) proteins are regulators of Ca2+ signaling that accelerate the GTPase activity of the G-protein alpha-subunit. RGS1, RGS2, RGS4, and RGS16 are expressed in the pancreas,... -
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- Viriditoxin Induces G2/M Cell Cycle Arrest and Apoptosis in A549 Human Lung Cancer Cells
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Park JH, Noh TH, Wang H, Kim ND, Jung JH
- KMID: 2312911
- Nat Prod Sci.
- 2015 Dec;21(4):282-288.
- doi: 10.20307/nps.2015.21.4.282
Viriditoxin is a fungal metabolite isolated from Paecilomyces variotii, which was derived from the giant jellyfish Nemopilema nomurai. Viriditoxin was reported to inhibit polymerization of FtsZ, which is a key... -
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- The role of the exocyst in renal ciliogenesis, cystogenesis, tubulogenesis, and development
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Lipschutz
- KMID: 2457718
- Kidney Res Clin Pract.
- 2019 Sep;38(3):260-266.
- doi: 10.23876/j.krcp.19.050
The exocyst is a highly conserved eight-subunit protein complex (EXOC1–8) involved in the targeting and docking of exocytic vesicles translocating from the trans-Golgi network to various sites in renal cells.... -
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- Rab GTPases as Physiological Substrates of LRRK2 Kinase
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Seol W, Nam D, Son I
- KMID: 2450209
- Exp Neurobiol.
- 2019 Apr;28(2):134-145.
- doi: 10.5607/en.2019.28.2.134
LRRK2 (Leucine-Rich Repeat Kinase 2) is a gene whose specific mutations cause Parkinson's disease (PD), the most common neurodegenerative movement disorder. LRRK2 harbors GTPase and kinase activities, two enzyme activities... -
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- Involvement of Protein Kinase C Isoforms and Rho GTPase in Contractile Response of Swine Pulmonary Artery
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Kim BK, Kim JH, Kim SH, Kim MJ, Kim YS, Lim JA, Choi YJ, Woo NS, Lee YC, Cho SI
- KMID: 2236828
- Korean J Anesthesiol.
- 2001 Feb;40(2):229-237.
- doi: 10.4097/kjae.2001.40.2.229
BACKGROUND: It is well established that vascular contraction is caused by not only an increase in cytosolic Ca2+ level but also activations of Ca2+-sensitizing mechanisms including protein kinase C (PKC)... -
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- Signal Transduction of Ras-like GTPase Activation in the Nervous System
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Kim DH, Park JK, Bae KW, Park HT
- KMID: 2030735
- Korean J Anat.
- 2001 Feb;34(1):13-21.
Synaptic plasticity has been thought to be a mechanism of synaptic maturation, learning and memory. In this study, the possible involvement of Rac, RhoA, proline-rich tyrosine kinase 2 (PYK2) and... -
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- The Changes in Insulin Secretion and GTPase Activity after the Exposure to High Glucose in Rat Pancreatic Islets
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Hong YS, Sung YA, Kyung NH
- KMID: 2331727
- J Korean Diabetes Assoc.
- 2000 Oct;24(5):515-523.
BACKGROUND: Type 2 diabetes mellitus is characterized by defective glucose- induced and glucose-potentiated insulin secretion. Chronic elevation of glucose levels are considered to be a cause of impaired insulin secretion.... -
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- Expression of RhoA in Colorectal Cancers and Its Clinicopathological Significance
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Jung HI, Choi YY, Baek MJ, Bae SH, Bae SB, Jung DJ, Kim SY, Lee MS, Cho MS, Kim CH
- KMID: 2198862
- J Korean Soc Coloproctol.
- 2008 Dec;24(6):460-466.
- doi: 10.3393/jksc.2008.24.6.460
PURPOSE: The Rho family of GTPases are involved in actin cytoskeleton organization and are associated with carcinogenesis and progression of human cancers. The clinicopathological significance of RhoA is not yet... -
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- Radiologic and Pathologic Findings of a Follicular Variant of Papillary Thyroid Cancer with Extensive Stromal Fat: A Case Report
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Choi JW, Kim TH, Roh HG, Moon WJ, Lee SH, Hwang TS, Park KS
- KMID: 2344291
- Korean J Radiol.
- 2015 Dec;16(6):1349-1352.
- doi: 10.3348/kjr.2015.16.6.1349
Thyroid cancer may have small adipose structures detected by microscopy. However, there are no reports of thyroid cancer with gross fat evaluated by radiological methods. We reported a case of... -
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- Survive or thrive: tradeoff strategy for cellular senescence
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Park SC
- KMID: 2386962
- Exp Mol Med.
- 2017 Jun;49(6):e342.
- doi: 10.1038/emm.2017.94
Aging-dependent cellular behaviors toward extrinsic stress are characterized by the confined localization of certain molecules to either nuclear or perinuclear regions. Although most growth factors can activate downstream signaling in... -
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- Characteristics of the Molecular Interaction of Adaptor Proteins in Protein Tyrosine Kinase Cascades
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Park YK, Choi SJ, Park RK, Chung SY, Kim SK
- KMID: 2048558
- Chonnam Med J.
- 1998 Dec;34(2):157-176.
Recent evidence suggests that FcgammaR and FcgammaR receptors signal through the low molecular weight GTPase, Ras. Ras is regulated by the nucleotide exchange protein, Sos, via formation of Grb2/Sos complex.... -
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- Clathrin and Lipid Raft-dependent Internalization of Porphyromonas gingivalis in Endothelial Cells
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Kim SY, Kim SH, Choi EK, Paek YW, Kang IC
- KMID: 1727430
- Int J Oral Biol.
- 2014 Sep;39(3):131-136.
Porphyromonas gingivalis is one of the most important periodontal pathogens and has been to known to invade various types of cells, including endothelial cells. The present study investigated the mechanisms... -
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- Mon1 Is Essential for Fungal Virulence and Stress Survival in Cryptococcus neoformans
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Son YE, Jung WH, Oh SH, Kwak JH, Cardenas M, Park HS
- KMID: 2428809
- Mycobiology.
- 2018 Jun;46(2):114-121.
- doi: 10.1080/12298093.2018.1468053
Mon1 is a guanine nucleotide exchange factor subunit that activates the Ypt7 Rab GTPase and is essential for vacuole trafficking and autophagy in eukaryotic organisms. Here, we identified and characterized... -
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- Polymorphisms in RAS Guanyl-releasing Protein 3 are Associated with Chronic Liver Disease and Hepatocellular Carcinoma in a Korean Population
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Oh AR, Lee SK, Kim MH, Cheong JY, Cho SW, Yang KS, Kwack K
- KMID: 2166418
- Genomics Inform.
- 2008 Dec;6(4):181-191.
RAS guanyl-releasing protein 3 (RasGRP3), a member of the Ras subfamily of GTPases, functions as a guanosine triphosphate (GTP)/guanosine diphosphate (GDP)-regulated switch that cycles between inactive GDP- and active GTP-bound... -
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- Regulation of Guanine Nucleotide Binding Protein Activity in Normal Rat Pancreatic Islet Secretory Granule by Arachidonic Acid and its Metabolites
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Sung YA
- KMID: 2331717
- J Korean Diabetes Assoc.
- 1999 Apr;23(2):120-130.
BACKGROUND: Arachidonic acid (AA) generated by the activation of phospholipase A2. and 12hydroxyeicasateraenoic acid (12-HEIE), a lipoxygenase metabolite of AA stimulates glucose induced insulin secretion in pancreatic islets, whereas prostaglandin... -
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- Multiple Effects of a Novel Epothilone Analog on Cellular Processes and Signaling Pathways Regulated by Rac1 GTPase in the Human Breast Cancer Cells
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Zhang H, An F, Tang L, Qiu R
- KMID: 2285499
- Korean J Physiol Pharmacol.
- 2014 Apr;18(2):109-120.
- doi: 10.4196/kjpp.2014.18.2.109
The epothilones are a class of microtubule inhibitors that exhibit a strong antitumor activity. UTD2 is a novel epothilone analog generated by genetic manipulation of the polyketide biosynthetic gene cluster.... -
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- Diverse Effects of Small Molecule Inhibitors on Actin Cytoskeleton Dynamics in HIV-1 Infection
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Shin Y, Choi BS, Kim KC, Kim K, Yoon CH
- KMID: 2452048
- J Bacteriol Virol.
- 2019 Jun;49(2):69-80.
- doi: 10.4167/jbv.2019.49.2.69
The dynamics of the actin cytoskeleton plays a pivotal role in the process of cell division, the transportation of organelles, vesicle trafficking and cell movement. Human immunodeficiency virus type 1... -
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