- Preferential Cytotoxic Effect of Genistein on G361 Melanoma Cells Via Inhibition of the Expression of Focal Adhesion Kinase
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Park SR, Kwak HH, Park BS, Kim GC
- KMID: 1431133
- Int J Oral Biol.
- 2012 Dec;37(4):189-195.
Resistance to the induction of apoptosis is a possible mechanism by which tumor cells can survive anti-neoplastic treatments. Melanoma is notoriously resistant to anti-neoplastic therapy. Previous studies have demonstrated focal... -
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- Signal Transduction of Ras-like GTPase Activation in the Nervous System
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Kim DH, Park JK, Bae KW, Park HT
- KMID: 2030735
- Korean J Anat.
- 2001 Feb;34(1):13-21.
Synaptic plasticity has been thought to be a mechanism of synaptic maturation, learning and memory. In this study, the possible involvement of Rac, RhoA, proline-rich tyrosine kinase 2 (PYK2) and... -
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- Effect of Cryotherapy on Focal Adhesion Kinase in Retinal Pigment Epithelial Cells
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Lee JG, Heo JW, Chung H
- KMID: 2207660
- J Korean Ophthalmol Soc.
- 2005 Feb;46(2):360-365.
PURPOSE: In the pathogenesis of proliferative vitreoretinopathy (PVR), retinal pigment epithelial (RPE) cells do not undergo apoptosis after separation from the basement membrane. In order to investigate the mechanism by... -
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- The Expression of beta- & alpha-Catenin and Focal Adhesion Kinase in Invasive Cervical Cancers
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Moon HS, Choi EA, Chung HW, Kim SC
- KMID: 1925515
- Korean J Obstet Gynecol.
- 2002 Aug;45(8):1317-1323.
OBJECTIVE: E-cadherin/catenin adhesion complex is fundamentally involved in epithelial cancer invasion and metastasis. Focal adhesion kinase (FAK) is one of the molecules that may be involved in the regulation of... -
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- The Role of Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN) in Lung Cancer
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Lee HK, Lee YC
- KMID: 2325380
- J Lung Cancer.
- 2004 Mar;3(1):1-5.
Lung cancer remains the primary cause of cancer-related death in the world, and the number of cases continues to increase. Like any other human cancer, the development of lung cancer... -
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- Expression of Cortactin and Focal Adhesion Kinase in Colorectal Adenocarcinoma: Correlation with Clinicopathologic Parameters and Their Prognostic Implication
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Kim YN, Choi JE, Bae JS, Jang KY, Chung MJ, Moon WS, Kang MJ, Lee DG, Park HS
- KMID: 2277486
- Korean J Pathol.
- 2012 Oct;46(5):454-462.
BACKGROUND: Cortactin and focal adhesion kinase (FAK) are two important components among actin cross-linking proteins that play a central role in cell migration. METHODS: The aims of this study were to... -
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- Luteolin attenuates migration and invasion of lung cancer cells via suppressing focal adhesion kinase and non-receptor tyrosine kinase signaling pathway
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Masraksa W, Tanasawet , Hutamekalin P, Wongtawatchai T, Sukketsiri W
- KMID: 2471880
- Nutr Res Pract.
- 2020 Apr;14(2):127-133.
- doi: 10.4162/nrp.2020.14.2.127
BACKGROUND/OBJECTIVES: Non-small cell lung cancer is mostly recognized among other types of lung cancer with a poor prognosis by cause of chemotherapeutic resistance and increased metastasis. Luteolin has been found... -
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- The Control of Tumor Cell Invasiveness in Chondrosarcoma Cell Lines by Modifying Focal Adhesion Kinase Expression
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Kim YH, Park HB, Shin KH, Hahn SB, Lee JW
- KMID: 2105890
- J Korean Orthop Assoc.
- 2002 Aug;37(4):552-558.
PURPOSE: We propose that cell attachment and invasion can be regulated by the modulation of FAK expression in chondrosarcoma cell lines. MATERIALS AND METHODS: The C-terminal domain of FAK (FAK-CD) was... -
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- Syntenin Is Expressed in Human Follicular Dendritic Cells and Involved in the Activation of Focal Adhesion Kinase
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Cho W, Kim H, Lee JH, Hong SH, Choe J
- KMID: 1493614
- Immune Netw.
- 2013 Oct;13(5):199-204.
- doi: 10.4110/in.2013.13.5.199
Syntenin is an adaptor molecule containing 2 PDZ domains which mediate molecular interactions with diverse integral or cytoplasmic proteins. Most of the results on the biological function of syntenin were... -
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- Role of Tumor Necrosis Factor Alpha, Interleukin 8 and Dexamethasone in the FAK Expression by Human Nucleus Pulposus Cells
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Yoon JH, Lee JH
- KMID: 1575167
- J Korean Orthop Res Soc.
- 2006 Apr;9(1):40-47.
PURPOSE: Human nucleus pulposus cells from intervertebral disc specimens were cultured to study the effects of TNF-alphaand IL-8 on the FAK expression by these cells. The effect of co-stimulation with... -
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- LRRK2 Inhibits FAK Activity by Promoting FERM-mediated Autoinhibition of FAK and Recruiting the Tyrosine Phosphatase, SHP-2
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Choi I, Byun JW, Park SM, Jou I, Joe EH
- KMID: 2354880
- Exp Neurobiol.
- 2016 Oct;25(5):269-276.
- doi: 10.5607/en.2016.25.5.269
Mutation of leucine-rich repeat kinase 2 (LRRK2) causes an autosomal dominant and late-onset familial Parkinson's disease (PD). Recently, we reported that LRRK2 directly binds to and phosphorylates the threonine 474... -
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- The control of chondroid cell's adhesiveness by modulation of focal adhesion kinase(FAK) expression
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Lee JW, Kim YH, Hahn SB, Shin KH, Park HB
- KMID: 1828540
- J Korean Orthop Res Soc.
- 2001 Oct;4(2):159-166.
PURPOSE: We propose that cell attachment can be regulated by the modulation of FAK expression using an adenovirus vector. MATERIALS AND METHODS: Chondrocytes and chondroid cells were used in cell... -
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- The Role of Focal Adhesion Kinase in the TGF-beta-Induced Myofibroblast Transdifferentiation of Human Tenon's Fibroblasts
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Hong S, Lee JB, Iizuka Y, Song YK, Seong GJ, Han SH
- KMID: 1120181
- Korean J Ophthalmol.
- 2012 Feb;26(1):45-48.
- doi: 10.3341/kjo.2012.26.1.45
PURPOSE: To investigate the role of focal adhesion kinase (FAK) in transforming growth factor (TGF)-beta-induced myofibroblast transdifferentiation of human Tenon's fibroblasts. METHODS: Primary cultured human Tenon's fibroblasts were exposed to TGF-beta1... -
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- Cross-linking of CD80 and CD86 Diminishes Expression of CD54 on EBV-transformed B Cells through Inactivation of RhoA and Ras
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Park GB, Kim YS, Song H, Kim S, Park DM, Lee WJ, Hur DY
- KMID: 2150725
- Immune Netw.
- 2011 Dec;11(6):390-398.
- doi: 10.4110/in.2011.11.6.390
BACKGROUND: Epstein Barr virus (EBV) infected B cells are transformed into lymphoblastoid cell lines. Some researchers suggested some a few similarities between this process and carcinogenesis. We observed the expression... -
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- Identification of the Marker-Genes for Dioxin(2,3,7,8-tetradibenzo-p-dioxin)-Induced Immune Dysfunction by Using the High-Density Oligonucleotide Microarray
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Kim JA, Lee EJ, Kim HL
- KMID: 2166168
- Genomics Inform.
- 2004 Jun;2(2):75-80.
In a variety of animal species, the perinatal exposure of experimental animals to the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) leads to the immune dysfunction, which is more severe and persistent than that caused... -
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- Induction of Integrin Signaling by Steroid Sulfatase in Human Cervical Cancer Cells
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Ye DJ, Kwon YJ, Shin S, Baek HS, Shin DW, Chun YJ
- KMID: 2378811
- Biomol Ther.
- 2017 May;25(3):321-328.
- doi: 10.4062/biomolther.2016.155
Steroid sulfatase (STS) is an enzyme responsible for the hydrolysis of aryl and alkyl sulfates. STS plays a pivotal role in the regulation of estrogens and androgens that promote the... -
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- Roles of FGF-4 on the Differentiation of Trophoblast Stem (TS) Cells
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Choi MK, Oh JT, Oh JM
- KMID: 2030758
- Korean J Anat.
- 2004 Apr;37(2):141-148.
Fibroblast growth factor-4 (FGF-4) has various functions, affecting many signaling pathways, and leading to cellular proliferation and differentiation and to the regulation of cell migration, invasion, and angiogenesis. However, there... -
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- Syntenin increases the invasiveness of small cell lung cancer cells by activating p38, AKT, focal adhesion kinase and SP1
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Kim WY, Jang JY, Jeon YK, Chung DH, Kim YG, Kim CW
- KMID: 2155355
- Exp Mol Med.
- 2014 Apr;46(4):e90.
- doi: 10.1038/emm.2014.1
Syntenin is a PDZ domain-containing adaptor protein that has been recently shown to regulate migration and invasion in several tumors. Small cell lung cancer (SCLC) is notorious for its invasiveness... -
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- Bacitracin Inhibits the Migration of U87-MG Glioma Cells via Interferences of the Integrin Outside-in Signaling Pathway
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Li S, Li C, Ryu HH, Lim SH, Jang WY, Jung S
- KMID: 2192039
- J Korean Neurosurg Soc.
- 2016 Mar;59(2):106-116.
- doi: 10.3340/jkns.2016.59.2.106
OBJECTIVE: Protein disulfide isomerase (PDI) acts as a chaperone on the cell surface, and it has been reported that PDI is associated with the tumor cell migration and invasion. The... -
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- The Effect of Hydrogen Peroxide on the Migration and FAK Activation in Lens Epithelial Cells
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Park YM, Kim JA, Ahn BT, Wee WR, Lee JH, Lee YC, Kim HS, Joo CK
- KMID: 2109218
- J Korean Ophthalmol Soc.
- 2001 Sep;42(9):1336-1343.
PURPOSE: Hydrogen peroxide has been implicated as a causative factor of various cellular dysfunction, cell death, transformation. In addition, oxidative stress has been suggested as a crucial inducer of cataract... -
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