- Cell Therapy for Wound Healing
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You HJ, Han SK
- KMID: 1734915
- J Korean Med Sci.
- 2014 Mar;29(3):311-319.
- doi: 10.3346/jkms.2014.29.3.311
In covering wounds, efforts should include utilization of the safest and least invasive methods with goals of achieving optimal functional and cosmetic outcome. The recent development of advanced wound healing... -
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- Synthesized TGF-beta s in RPE regulates cellular proliferation
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Lee SC, Seong GJ, Kim SH, Kwon OW
- KMID: 1081831
- Korean J Ophthalmol.
- 1999 Jun;13(1):16-24.
- doi: 10.3341/kjo.1999.13.1.16
Retinal pigment epithelial (RPE) cells transdifferentiate in culture, a transition which is accompanied by a shift in biological activity. The present study investigates whether transforming growth factor (TGF)-beta has the... -
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- Evaluation of Stem Cell Components in Retrocorneal Membranes
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Lee SH, Kim KW, Kim MK, Chun YS, Kim JC
- KMID: 1796949
- J Korean Med Sci.
- 2014 Jun;29(6):846-851.
- doi: 10.3346/jkms.2014.29.6.846
The purpose of this study was to elucidate the origin and cellular composition of retrocorneal membranes (RCMs) associated with chemical burns using immunohistochemical staining for primitive cell markers. Six cases... -
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- Protective Effect of Heat Shock Protein 70 Against Oxidative Stresses in Human Corneal Fibroblasts
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Kim YS, Han JA, Cheong TB, Ryu JC, Kim JC
- KMID: 2157691
- J Korean Med Sci.
- 2004 Aug;19(4):591-597.
- doi: 10.3346/jkms.2004.19.4.591
We evaluated DNA protection effect of heat shock protein (HSP) against cytotoxic effects of exogenous nitric oxide (NO) and reactive oxygen intermediate (ROI). Cultured human corneal fibroblasts were divided into... -
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- The Role of Focal Adhesion Kinase in the TGF-beta-Induced Myofibroblast Transdifferentiation of Human Tenon's Fibroblasts
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Hong S, Lee JB, Iizuka Y, Song YK, Seong GJ, Han SH
- KMID: 1120181
- Korean J Ophthalmol.
- 2012 Feb;26(1):45-48.
- doi: 10.3341/kjo.2012.26.1.45
PURPOSE: To investigate the role of focal adhesion kinase (FAK) in transforming growth factor (TGF)-beta-induced myofibroblast transdifferentiation of human Tenon's fibroblasts. METHODS: Primary cultured human Tenon's fibroblasts were exposed to TGF-beta1... -
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- Efficient culture system for human embryonic stem cells using autologous human embryonic stem cell-derived feeder cells
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Yoo SJ, Yoon BS, Kim JM, Song JM, Roh SI, You S, Yoon HS
- KMID: 1089449
- Exp Mol Med.
- 2005 Oct;37(5):399-407.
Human embryonic stem cells (hESCs) need feeder cells for their maintenance in an undifferentiated state. In conventional culture systems, mouse embryonic fibroblasts (MEFs) serve as feeder cells to maintain hESCs.... -
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- A Comparative Study of Magnetic-Activated Cell Sorting, Cytotoxicity and Preplating for the Purification of Human Myoblasts
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Park YG, Moon JH, Kim J
- KMID: 1110739
- Yonsei Med J.
- 2006 Apr;47(2):179-183.
- doi: 10.3349/ymj.2006.47.2.179
Although cultured myoblast transplantation has been extensively studied as a gene complementation approach to muscular dystrophy treatment, clinical success has still been limited. The inability to adequately isolate and purify... -
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- Recombinant tetra-cell adhesion motifs supports adhesion, migration and proliferation of keratinocytes/fibroblasts, and promotes wound healing
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Jung MY, Thapa N, Kim JE, Yang JD, Cho BC, Kim IS
- KMID: 1090969
- Exp Mol Med.
- 2007 Oct;39(5):663-672.
An extracellular matrix protein plays an important role in skin wound healing. In the present study, we engineered a recombinant protein encompassing the 9th and 10th type III domains of... -
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- Little role of anti-gB antibodies in neutralizing activity of patient's sera with human cytomegalovirus (HCMV) infection
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Park JW, Kim DJ, Kim J, Park CG, Hwang ES, Cha CY
- KMID: 648113
- J Korean Med Sci.
- 2000 Apr;15(2):133-138.
- doi: 10.3346/jkms.2000.15.2.133
Human cytomegalovirus (HCMV) gB is known to play important roles in cell surface attachment, virion penetration, spread of infection from cell to cell, and provocation of neutralizing antibody. This study... -
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- Cytotoxicity and multinucleate giant cell formation in Chinese hamster lung fibroblast caused by crocidolite and chrysotile
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Hong YC, Choi SS
- KMID: 1079654
- J Korean Med Sci.
- 1997 Apr;12(2):99-104.
- doi: 10.3346/jkms.1997.12.2.99
The mechanism of carcinogenic action of asbestos remains unclear but the physical properties of the fiber appear to be important in this process. Asbestos may cause multinucleate giant cell... -
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- Disease-specific induced pluripotent stem cells: a platform for human disease modeling and drug discovery
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Jang J, Yoo JE, Lee JA, Lee DR, Kim JY, Huh YJ, Kim DS, Park CY, Hwang DY, Kim HS, Kang HC, Kim DW
- KMID: 1245263
- Exp Mol Med.
- 2012 Mar;44(3):202-213.
- doi: 10.3858/emm.2012.44.3.015
The generation of disease-specific induced pluripotent stem cell (iPSC) lines from patients with incurable diseases is a promising approach for studying disease mechanisms and drug screening. Such innovation enables to... -
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- Overexpression of bone morphogenetic protein 4 in STO fibroblast feeder cells represses the proliferation of mouse embryonic stem cells in vitro
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Kim GH, Lee GR, Choi HI, Park NH, Chung HT, Han IS
- KMID: 1397450
- Exp Mol Med.
- 2012 Jul;44(7):457-463.
Embryonic stem cells (ESCs) can be propagated in vitro on feeder layers of mouse STO fibroblast cells. The STO cells secrete several cytokines that are essential for ESCs to maintain... -
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- The effect of dichlorotriazinyl aminofluorescein on human keratocytes in vitro
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Wee WR, Rofougaran R, Pakkar A, Hayashi S, McDonnell
- KMID: 1735160
- Korean J Ophthalmol.
- 1996 Dec;10(2):63-67.
- doi: 10.3341/kjo.1996.10.2.63
Dichlorotriazinyl aminofluorescein (DTAF) has been used to stain corneal stromal collagen as part of in vivo animal experiments for many years. Toxicity of this drug, if present, might alter the... -
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- Downstream molecular events in the altered profiles of lysophosphatidic acid-induced cAMP in senescent human diploid fibroblasts
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Jang IS, Rhim JH, Park SC, Yeo EJ
- KMID: 1111406
- Exp Mol Med.
- 2006 Apr;38(2):134-143.
Lysophosphatidic acid (LPA) is a phospholipid growth factor that acts through G-protein-coupled receptors. Previously, we demonstrated an altered profile of LPA-dependent cAMP content during the aging process of human diploid... -
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- Podoplanin, alpha-Smooth Muscle Actin or S100A4 Expressing Cancer-Associated Fibroblasts Are Associated with Different Prognosis in Colorectal Cancers
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Choi SY, Sung R, Lee SJ, Lee TG, Kim N, Yoon SM, Lee EJ, Chae HB, Youn SJ, Park SM
- KMID: 1793043
- J Korean Med Sci.
- 2013 Sep;28(9):1293-1301.
- doi: 10.3346/jkms.2013.28.9.1293
The interactions between the tumor microenvironment and tumor cells determine the behavior of the primary tumors. Whether cancer-associated fibroblasts (CAF) have a tumor progressive or a protective role likely depends... -
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- The Role of Nitric Oxide in Ocular Surface Cells
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Kim JC, Park GS, Kim JK, Kim YM
- KMID: 1101556
- J Korean Med Sci.
- 2002 Jun;17(3):389-394.
- doi: 10.3346/jkms.2002.17.3.389
The role of nitric oxide (NO) in the ocular surface remains unknown. We investigated the conditions leading to an increase of NO generation in tear and the main sources of... -
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- Human telomerase catalytic subunit (hTERT) suppresses p53-mediated anti-apoptotic response via induction of basic fibroblast growth factor
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Jin X, Beck S, Sohn YW, Kim JK, Kim SH, Yin J, Pian X, Kim SC, Choi YJ, Kim H
- KMID: 1104384
- Exp Mol Med.
- 2010 Aug;42(8):574-582.
- doi: 10.3858/emm.2010.42.8.058
Although human telomerase catalytic subunit (TERT) has several cellular functions including telomere homeostasis, genomic stability, cell proliferation, and tumorigenesis, the molecular mechanism underlying anti-apoptosis regulated by TERT remains to be... -
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- Therapeutic Effect of Allogenic Bone Marrow Transplantation in Acute TNBS-induced Colitis
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Maeng LS, Chang ED, Chae HS, Kim JS, Min JY, Sohn HS, Rho SY, Kim HK, Cho YS, Choi KY, Lee HK
- KMID: 1792762
- Korean J Gastroenterol.
- 2009 Jul;54(1):20-27.
- doi: 10.4166/kjg.2009.54.1.20
BACKGROUND/AIMS: Bone marrow-derived cells (BMDC) contribute to tissue maintenance under many kinds of pathologic conditions. We carried out a study to see how BMDC play a role in the treatment... -
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- Fibrovascularization of Intraorbital Hydroxyapatite-Coated Alumina Sphere in Rabbits
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Chung WS, Song SJ, Lee SH, Kim EA
- KMID: 1099079
- Korean J Ophthalmol.
- 2005 Mar;19(1):9-17.
- doi: 10.3341/kjo.2005.19.1.9
We investigated the fibrovascular ingrowth and fibrovascular tissue maturation of hydroxyapatite-coated, porous alumina sphere (Alumina sphere) in comparison with the hydroxyapatite sphere (HAp sphere) in rabbits. Alumina spheres and HAp... -
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