- An improved method for constructing a full-length enriched cDNA library using small amounts of total RNA as a starting material
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Oh JH, Kim YS, Kim NS
- KMID: 1119343
- Exp Mol Med.
- 2003 Dec;35(6):586-590.
We have developed an improved method for constructing a full-length cDNA library using small quantity of material by modifying the original oligo-capping method. In our devised method, total RNAs are... -
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- Melting of complexes of DNA-cis-DDP in acidic environment
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Dalyan YB, Haroutiunian TS, Haroutiunian SG, Vardevanyan PO
- KMID: 1119335
- Exp Mol Med.
- 2003 Dec;35(6):534-537.
The peculiarities of helix-coil transition of DNA at complex-formation with cis-diamminedichlorplatinum (II) (cis-DDP) have been investigated in acidic environment by UV absorbance technique. It is shown that observed features of... -
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- Adenoviral mediated hepatocyte growth factor gene attenuates hyperglycemia and beta cell destruction in overt diabetic mice
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Park MK, Kim DK, Lee HJ
- KMID: 1119330
- Exp Mol Med.
- 2003 Dec;35(6):494-500.
Hepatocyte growth factor (HGF) is a potent mitogen and promoter of proliferation of insulin producing beta cells of pancreatic islets. To study the role of HGF, an adenoviral vector carrying... -
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- Angiotensin converting enzyme I/D, angiotensinogen T174M-M235T and angiotensin II type 1 receptor A1166C gene polymorphisms in Turkish hypertensive patients
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Agachan B, Isbir T, Yilmaz H, Akoglu E
- KMID: 1119337
- Exp Mol Med.
- 2003 Dec;35(6):545-549.
Essential hypertension is a multifactorial disease in which genetic and enviromental factors play an important role. These factors differ in each population. As there are no existing data for the... -
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- Vitamin D receptor gene polymorphisms in breast cancer
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Buyru N, Tezol A, Yosunkaya-Fenerci E, Dalay N
- KMID: 1119338
- Exp Mol Med.
- 2003 Dec;35(6):550-555.
Breast cancer is the leading cause of cancer death among women around the world and its incidence is annually increasing. The vitamin D receptor (VDR) gene is a member of... -
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- Role of crosslinked protein in lung injury following total body irradiation and bone marrow transplantation
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Lee SY, Kim YJ, Kim YJ
- KMID: 1119340
- Exp Mol Med.
- 2003 Dec;35(6):565-571.
The aberrant protein crosslinks formation during lung injury as results total body irradiation (TBI) and bone marrow transplantation (BMT) therapy has been examined as apossible contributory factor in organ or... -
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- Targeting efficiency of a-1,3-galactosyl transferase gene in pig fetal fibroblast cells
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Jin DI, Lee SH, Choi JH, Lee JS, Lee JE, Park KW, Seo JS
- KMID: 1119341
- Exp Mol Med.
- 2003 Dec;35(6):572-577.
Animal cloning technology with somatic cells provides an alternative tool to conventional methods for producing transgenic animals. Gene targeting in animals is made feasible using somatic cells with homologous recombination... -
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- The binding of ethidium bromide with DNA: interaction with single- and double-stranded structures
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Vardevanyan PO, Antonyan A, Parsadanyan MA, Davtyan HG, Karapetyan AT
- KMID: 1119334
- Exp Mol Med.
- 2003 Dec;35(6):527-533.
The pH-induced helix-coil transition of DNA and its complexes with EtBr is carried out at acidic pH in a wide interval of change of concentration ratio of EtBr/DNA. The binding... -
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- Atrophy of brown adipocytes in the adult mouse causes transformation into white adipocyte-like cells
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Kim DW, Kim BS, Kwon HS, Kim CG, Lee HW, Choi WH, Kim CG
- KMID: 1119333
- Exp Mol Med.
- 2003 Dec;35(6):518-526.
Adipose tissue is an important endocrine regulator of glucose metabolism and energy homeostasis. Researches have focused on this tissue not only as a target for pharmacotherapy of obesity and insulin... -
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- Protein kinase CK2 phosphorylates and interacts with deoxyhypusine synthase in HeLa cells
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Kang KR, Chung SI
- KMID: 1119339
- Exp Mol Med.
- 2003 Dec;35(6):556-564.
Deoxyhypusine is a modified lysine and formed posttranslationally to be the eukaryotic initiation factor eIF5A by deoxyhypusine synthase, employing spermidine as butylamine donor. Subsequent hydroxylation of this deoxyhypusine-containing intermediate completes... -
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- Biochemical properties of full-length hepatitis C virus RNA-dependent RNA polymerase expressed in insect cells
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Choi HB, Kim YG, Oh JW
- KMID: 1119328
- Exp Mol Med.
- 2003 Dec;35(6):475-485.
The hepatitis C virus (HCV) RNA-dependent RNA polymerase, NS5B protein, is the key viral enzyme responsible for replication of the HCV viral RNA genome. Although several full-length and truncated forms... -
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- Constitutive expression of 4-1BB on T cells enhances CD4+ T cell responses
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Kim J, Choi SP, La S, Seo JS, Kim KK, Nam SH, Kwon B
- KMID: 1119332
- Exp Mol Med.
- 2003 Dec;35(6):509-517.
4-1BB, a transmembrane molecule, member of the tumor necrosis factor receptor superfamily, is an important costimulatory molecule in the immune response, plays a key role in the clonal expansion and... -
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- Nonspecific association of 2',3'-cyclic nucleotide 3'-phosphodiesterase with the rat forebrain postsynaptic density fraction
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Cho SJ, Jung JS, Shin SC, Jin IN, Ko BH, Kim Kwon Y, Suh-Kim H, Moon IS
- KMID: 1119329
- Exp Mol Med.
- 2003 Dec;35(6):486-493.
The 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), a protein of unknown function in vivo, is abundantly expressed in myelinating glia in two isoforms, CNP1 and CNP2. In this study, immunoblot analysis showed... -
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- Resveratrol derivatives potently induce apoptosis in human promyelocytic leukemia cells
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Kang JH, Park YH, Choi SW, Yang EK, Lee WJ
- KMID: 1119327
- Exp Mol Med.
- 2003 Dec;35(6):467-474.
Resveratrol has been shown to possess antioxidant and anticancer activities, but little is known on the effect of resveratrol derivatives. Recently we have isolated resveratrol and its dimers and trimers... -
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- Dysferlin in a hyperCKaemic patient with caveolin 3 mutation and in C2C12 cells after p38 MAP kinase inhibition
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Capanni C, Sabatelli , Mattioli E, Ognibene A, Columbaro , Lattanzi G, Merlini L, Minetti C, Maraldi NM, Squarzoni
- KMID: 1119336
- Exp Mol Med.
- 2003 Dec;35(6):538-544.
Dysferlin is a plasma membrane protein of skeletal muscle whose deficiency causes Miyoshi myopathy, limb girdle muscular dystrophy 2B and distal anterior compartment myopathy. Recent studies have reported that dysferlin... -
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- Differential inhibition of endothelial cell proliferation and migration by urokinase subdomains: amino-terminal fragment and kringle domain
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Kim KS, Hong YK, Lee Y, Shin JY, Chang SI, Chung SI, Joe YA
- KMID: 1119342
- Exp Mol Med.
- 2003 Dec;35(6):578-585.
The serine protease urokinase-type plasminogen activator (uPA) is implicated in pericellular proteolysis in a variety of physiological and pathological processes including angiogenesis and tumor metastasis. The kringle domain of uPA... -
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- High levels of soluble herpes virus entry mediator in sera of patients with allergic and autoimmune diseases
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Jung HW, La SJ, Kim JY, Heo SK, Kim JY, Wang S, Kim KK, Lee KM, Cho HR, Lee HW, Kwon B, Kim BS, Kwon BS
- KMID: 1119331
- Exp Mol Med.
- 2003 Dec;35(6):501-508.
Herpes virus entry mediator (HVEM) is a newly discovered member of the tumor necrosis factor receptor (TNFR) superfamily that has a role in herpes simplex virus entry, in T cell... -
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