Exp Mol Med.
2003 Dec;35(6):534-537.
Melting of complexes of DNA-cis-DDP in acidic environment
- Affiliations
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- 1Department of Molecular Physics of the Physical Faculty, 375025 Yerevan, Alek Manoogian St., 1, Armenia.
- 2Department of Biophysics of the Biological Faculty of Yerevan State University, 375025 Yerevan, Alek Manoogian St., 1, Armenia. simvar@arminco.com
Abstract
- The peculiarities of helix-coil transition of DNA at complex-formation with cis-diamminedichlorplatinum (II) (cis-DDP) have been investigated in acidic environment by UV absorbance technique. It is shown that observed features of behavior delta T (pH) and T(m)(pH) DNA at pH 2.8-3.0 are possible to explain by formation in DNA of pseudo-ring structures at covalent linking of cis-DDP with DNA.
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