Ewha Med J.  1990 Dec;13(4):301-306. 10.12771/emj.1990.13.4.301.

The Experimental Study on the Effect of Radiation and Cis-Dichlorodiammineplatinum(II) in Rat Skin

• Lee KJ

• KMID: 2170843
• DOI: http://doi.org/10.12771/emj.1990.13.4.301

Abstract

The interaction of Cis-dichlorodiammineplatinum(II)(Cis-DDP) with irradiation may be important in the clinical settings for which this drug is currently used. Since the skin is a major tissue for the uptake of Cis-DDP and its uptake level persists for several days, experiments were designed to evaluate the potential of Cis-DDP for enhancing the damage or the irradiated skin in rats. For experiments, 42 rats were used and radiation dose was 30Gy in single fraction and the dose of Cis-DDP was 2.5mg/kg. The results of these experiments suggest that a Cis-DDP dose of 2.5mg/kg produces no incrase skin damage when the drug was administered IP 30min before, or 15min after irradiation.

MeSH Terms

Animals
Cisplatin*
Rats*
Skin*
Cisplatin