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The functional domains of dopamine transporter for cocaine analog, CFT binding

Lee SH, Chang MY, Jeon DJ, Oh DY, Son H, Lee CH, Lee YS, Lee YS

  • KMID: 1093603
  • Exp Mol Med.
  • 2002 Mar;34(1):90-94.
Cocaine analogue, CFT (2beta-carbomethoxy-3beta-(4-fluorophenyl) tropane) binding to dopamine transporter (DAT) in different species is quite heterogeneous. CFT is scarcely detected in bovine DAT whereas it is conspicuous in humans. To...
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Effects of chlorinated aliphatic hydrocarbons on the fidelity of cell division in human CYP2E1 expressing cells

Kim A, Parry EM, Parry JM

  • KMID: 1093602
  • Exp Mol Med.
  • 2002 Mar;34(1):83-89.
Chlorinated organic chemicals are widely used in industry and are present in the environment. Five chlorinated aliphatic hydrocarbons, namely 1-2-dichloroethane, 1,1,2-trichloroethane, trichloroethylene, 2,3-dichlorobutane and 1-chlorohexane were investigated to determine their...
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Expression of integrins, cyclooxygenases and matrix metalloproteinases in three-dimensional human endometrial cell culture system

Yang H, Han S, Kim H, Choi YM, Hwang KJ, Kwon HC, Kim SK, Cho DJ

  • KMID: 1093601
  • Exp Mol Med.
  • 2002 Mar;34(1):75-82.
The objective of this investigation was to establish a three-dimensionally cultured human endometrium which could be used as a tissue model for the mechanism study of implantation in vitro. By...
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Expression of aquaporin-5 and its regulation in skeletal muscle cells

Hwang SM, Lee RH, Song JM, Yoon S, Kim YS, Lee SJ, Kang SK, Jung JS

  • KMID: 1093600
  • Exp Mol Med.
  • 2002 Mar;34(1):69-74.
The aquaporins constitute a family of homologous intrinsic membrane proteins that function as highly selective water channels and are highly expressed in tissues where rapid water movement across the cell...
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Characterization of cis-acting elements in the rat ATP citrate-lyase gene promoter

Moon YA, Park SW, Kim KS

  • KMID: 1093599
  • Exp Mol Med.
  • 2002 Mar;34(1):60-68.
The cis-acting element in the promoter of the rat ATP-citrate lyase (ACL) and transcription factors which interact with these elements were determined. Six Sp1 binding sites and CAAT box exist...
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Enhanced expression of neuronal nitric oxide synthase and phospholipase C-gamma1 in regenerating murine neuronal cells by pulsed electromagnetic field

Kim SS, Shin HJ, Eom DW, Huh JR, Woo Y, Kim H, Ryu SH, Suh PG, Kim MJ, Kim JY, Koo TW, Cho YH, Chung SM

  • KMID: 1093598
  • Exp Mol Med.
  • 2002 Mar;34(1):53-59.
Pulsed electromagnetic field (PEMF) has been shown to improve the rate of peripheral nerve regeneration. In the present study we investigated the expression of neuronal nitric oxide synthase (nNOS) and...
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Aspartate modulates the ethanol-induced oxidative stress and glutathione utilizing enzymes in rat testes.

Oh SI, Lee MS, Kim CI, Song KY, Park SC

  • KMID: 1093597
  • Exp Mol Med.
  • 2002 Mar;34(1):47-52.
In order to develop a preventive strategy against ethanol-induced oxidative damages on various tissues and organs, we have examined the protective effect of aspartate on the pathogenesis of testes in...
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The p38 mitogen-activated protein kinase is involved in stress-induced phospholipase D activation in vascular smooth muscle cells

Min DS, Shin EY, Kim EG

  • KMID: 1093596
  • Exp Mol Med.
  • 2002 Mar;34(1):38-46.
Oxidative stress has been implicated in mediation of vascular disorders. Earlier study showed that the exposure of vascular smooth muscle cells (VSMC) to pervanadate (hydrogen peroxide plus orthovanadate) resulted in...
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D4-GDI is cleaved by caspase-3 during daunorubicin-induced apoptosis in HL-60 cells

Kwon KB, Park EK, Ryu DG, Park BH

  • KMID: 1093595
  • Exp Mol Med.
  • 2002 Mar;34(1):32-37.
Daunorubicin, an anti-cancer drug, is known to induce apoptosis in HL-60 cells in a dose-dependent manner through the activation of caspase-3 (CPP32). Caspase-3 selective inhibitor, Ac-DEVD-CHO, prevented both the activation...
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Differential modulation of zinc-stimulated p21(Cip/WAF1) and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells

Oh SY, Park KS, Kim AJ, Choi KY

  • KMID: 1093594
  • Exp Mol Med.
  • 2002 Mar;34(1):27-31.
Activation of the extra cellular signal regulated kinase (ERK) pathway is involved in both proliferation and growth arrest of cells depending on intensity and duration of stimuli. In this study,...
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Alterations of HLA class I and class II antigen expressions in borderline, invasive and metastatic ovarian cancers

Lee YS, Kim TE, Kim BK, Park YG, Kim GM, Jee SB, Ryu KS, Kim IK, Kim JW

  • KMID: 1093593
  • Exp Mol Med.
  • 2002 Mar;34(1):18-26.
In an effort to understand whether HLA class I and II plays any role in the process of tumorigenesis and metastasis, we have immunohistochemically examined expression of HLA class I...
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The stimulatory effect of IL-1beta on the insulin secretion of rat pancreatic islet is not related with iNOS pathway

Jeong IK, Oh SH, Chung JH, Min YK, Lee MS, Lee MK, Kim KW

  • KMID: 1093592
  • Exp Mol Med.
  • 2002 Mar;34(1):12-17.
Interleukin 1 (IL-1) is a pleiotropic cytokine with the potential to destroy pancreatic beta-cells, and thought to be involved in the pathogenesis of type I diabetes mellitus. Expression of inducible...
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Biomedical significance of endothelial cell specific growth factor, angiopoietin

Koh GY, Kim I, Kwak HJ, Yun MJ, Leem JC

  • KMID: 1093591
  • Exp Mol Med.
  • 2002 Mar;34(1):1-11.
Until recently, vascular endothelial growth factor (VEGF) was the only growth factor proven to be specific and critical for blood vessel formation. Other long-known factors, such as the fibroblast growth...
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