- Effect of MK801 and CNQX on Retinal Injury Induced by Ischemia, NMDA, or Kainate
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Choi JS, Gwag BJ, Yoon SK, Joo CK
- KMID: 2108525
- J Korean Ophthalmol Soc.
- 1998 Aug;39(8):1794-1800.
To examine the protection of retinal cell death by glutamate antagonists in vivo, this study was carried out in pressure-induced ischemia model. Firstly, we observed that ischemia resulted in the... -
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- The Effect of Intrathecal NMDA and non-NMDA Receptor Antagonist on the Hyperalgesia Observed after Thermal Injury in the Rat
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Jun JH
- KMID: 2039879
- Korean J Anesthesiol.
- 1998 Apr;34(4):708-715.
- doi: 10.4097/kjae.1998.34.4.708
BACKGROUND: Previous reports have described NMDA antagonist reduced the nerve injury induced or inflammatory thermal hyperalgesia. This study evaluated the effects of spinally administered excitatory amino acid antagonists on the... -
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- Meta-analysis on the Efficacy of Glutamate Receptor Antagonists for Acute Migraine Treatment
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Kim S, Baek IH
- KMID: 2470462
- Korean J Clin Pharm.
- 2019 Dec;29(4):247-253.
- doi: 10.24304/kjcp.2019.29.4.247
BACKGROUND: Glutamate is implicated in the pathophysiology of migraine, a common neurological disorder. Therefore, glutamate receptor antagonists (GluRAs) have been suggested as a novel migraine treatment that are able to... -
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- Treatment Effects of Glutamate Antagonist for Tinnitus
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Choung YH, Park HJ, Song JW, Ryu SJ, Moon SK, Park K
- KMID: 2276063
- Korean J Otolaryngol-Head Neck Surg.
- 2003 Nov;46(11):935-939.
BACKGROUND AND OBJECTIVES: Tinnitus is one of the most widespread disorders of the auditory system, affecting approximately 17% of the general population, with the frequency increasing to about 33% in... -
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- Mechanism of Hypoxia-Induced Cytotoxicity in Cultured Rat Retinal Neurons
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Yoon YH, Lee J
- KMID: 2123632
- J Korean Ophthalmol Soc.
- 1997 Nov;38(11):1975-1986.
Retinal neurons are highly vulnerable to hypoxia/ischemia. Excitotoxicity and free radical injury have been proposed as the major mechanisms of ischemic retinal injury have been proposed as the major mechanisms... -
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- Dual control of the vestibulosympathetic reflex following hypotension in rats
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Park SE, Jin YZ, Park BR
- KMID: 2395263
- Korean J Physiol Pharmacol.
- 2017 Nov;21(6):675-686.
- doi: 10.4196/kjpp.2017.21.6.675
Orthostatic hypotension (OH) is associated with symptoms including headache, dizziness, and syncope. The incidence of OH increases with age. Attenuation of the vestibulosympathetic reflex (VSR) is also associated with an... -
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- Effects of glutamate receptor antagonists and protein synthesis inhibitor on delayed neuronal death induced by transient global ischemia in rat brain
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Ko JS, Bae CS, Kim JK
- KMID: 1849835
- Korean J Physiol Pharmacol.
- 1998 Jun;2(3):279-286.
It has been well documented that transient forebrain global ischemia causes selective neuronal degeneration in hippocampal CA1 pyramidal neurons with a delay of a few days. The mechanism of this delayed hippocampal CA1... -
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- Functional Connections of the Vestibulo-spino-adrenal Axis in the Control of Blood Pressure Via the Vestibulosympathetic Reflex in Conscious Rats
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Lu HJ, Li MH, Li MZ, Park SE, Kim MS, Jin YZ, Park BR
- KMID: 2285587
- Korean J Physiol Pharmacol.
- 2015 Sep;19(5):427-434.
- doi: 10.4196/kjpp.2015.19.5.427
Significant evidence supports the role of the vestibular system in the regulation of blood pressure during postural movements. In the present study, the role of the vestibulo-spino-adrenal (VSA) axis in... -
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- Effect of Glutamate on the Vestibulo-Solitary Projection after Sodium Nitroprusside-Induced Hypotension in Conscious Rats
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Li LW, Jin GS, Yang YZ, Ameer AN, Kim MS, Park BR, Jin YZ
- KMID: 1791430
- Korean J Physiol Pharmacol.
- 2015 May;19(3):275-281.
- doi: 10.4196/kjpp.2015.19.3.275
Orthostatic hypotension is most common in elderly people, and its prevalence increases with age. Attenuation of the vestibulo-sympathetic reflex (VSR) is commonly associated with orthostatic hypotension. In this study, we... -
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- Involvement of Ionotropic, rather than Metabotropic, Glutamate Receptors in Hyperexcitability of Spinal orsal Neurons Induced after Spinal Cord Injury
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Gwak YS, Shim B, Yoon DM, Nam TS, Paik KS, Leem JW
- KMID: 1946656
- J Korean Pain Soc.
- 2002 Jun;15(1):48-57.
BACKGROUND: Spinal cord injury (SCI) induces the development of central neuropathic pain which is characterized by symptoms such as allodynia, hyperalgesia, and spontaneous pain. However, the underlying mechanism is not... -
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- The Effects of Glutamate Receptor Antagonists on Cultured Cerebral Cortical Neurons of Neonatal Mouse Damaged by Oxidative Stress
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Choi DH, Oh YK, Park ST
- KMID: 2335420
- J Korean Pediatr Soc.
- 1999 Aug;42(8):1096-1103.
PURPOSE: To evaluate neurotoxic effects induced by oxygen-radicals, which were generated by adding xanthine oxidase(XO) and hypoxanthine(HX), and protective effects of glutamate receptor antagonist such as MK-801 and 6-cyano-7-nitroquinoxaline(CNQX). METHODS:... -
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- The Role of NMDA Receptor Antagonists in Nicotine Tolerance, Sensitization, and Physical Dependence: A Preclinical Review
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Jain R, Mukherjee , Balhara YP
- KMID: 1084488
- Yonsei Med J.
- 2008 Apr;49(2):175-188.
- doi: 10.3349/ymj.2008.49.2.175
Nicotine, the primary psychoactive component of tobacco products, produces diverse neurophysiological, motivational, and behavioral effects through several brain regions and neurochemical pathways. Various neurotransmitter systems have been explored to understand... -
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- 6-hydroxydopamine Induces Neuronal Apoptosis in Mouse Cortical Cell Cultures
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Jung JH, Kang HJ, Sohn S, Chung YK, Gwag BJ, Noh JS
- KMID: 2340467
- J Korean Neuropsychiatr Assoc.
- 2000 May;39(3):656-665.
OBJECTIVES: We examined the patterns of cell death induced by the 6-hydroxydopamine, a selective dopaminergic toxin that used to produce Parkinson's disease model. METHOD: Neocortices from 14- or 15-day-old fetal mice... -
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- Effects of MK-801 (dizocilpine) on Brain Cell Membrane Function and Energy Metabolism in Experimental Escherichia coli Meningitis in the Newborn Piglet
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Ko SY, Shim JW, Kim SS, Kim MJ, Chang YS, Park WS, Shin SM, Lee MH
- KMID: 2157628
- J Korean Med Sci.
- 2003 Apr;18(2):236-241.
- doi: 10.3346/jkms.2003.18.2.236
We evaluated the efficacy of non-competitive N-methyl-D-aspartate receptor antagonist MK-801 (dizocilpine) as an adjuvant therapy in experimental neonal bacterial meningitis. Meningitis was induced by injecting 10(6) colony forming units of... -
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- Antinociceptive Interactions between Intrathecal Gabapentin and MK801 or NBQX in Rat Formalin Test
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Yoon MH, Bae HB, Choi JI
- KMID: 1095209
- J Korean Med Sci.
- 2005 Apr;20(2):307-312.
- doi: 10.3346/jkms.2005.20.2.307
Antagonists for spinal N-methyl-D-aspartate (NMDA) and amino-hydroxy-methtyl-isoxazolepropionate (AMPA) receptors are effective in attenuating acute nociception or injury-induced hyperalgesia. The antinociception of spinal gabapentin is developed in injury-induced hyperalgesia without affecting... -
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- Application of pulsed Doppler ultrasound for the evaluation of small intestinal motility in dogs
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An YJ, Lee H, Chang D, Lee Y, Sung JK, Choi M, Yoon J
- KMID: 1103510
- J Vet Sci.
- 2001 Apr;2(1):71-74.
The purpose of this study was to verify whether small intestinal peristalsis could be observed and quantitatively assessed using pulsed-Doppler ultrasound. Pulsed-Doppler ultrasound was used to evaluate small intestinal peristalsis... -
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- Neuroprotective effect of memantine in a rabbit model of optic nerve ischemia
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Kim TW, Kim DM, Park KH, Kim H
- KMID: 754312
- Korean J Ophthalmol.
- 2002 Jun;16(1):1-7.
- doi: 10.3341/kjo.2002.16.1.1
The purpose of this study was to evaluate the neuroprotective effect of memantine, a N-methyl-D-aspartate antagonist, in an experimental optic nerve ischemia. Endothelin-1 (ET-1) in a dosage of 0.1 microg/day... -
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- Immobilization with Ketamine HCl and Tiletamine-Zolazepam in Cynomolgus Monkeys
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Lee JI, Hong SH, Lee SJ, Kim YS, Kim MC
- KMID: 1089411
- J Vet Sci.
- 2003 Aug;4(2):187-191.
To compare the effects of ketamine and tiletaminezolazepam (TZ) drugs widely used for the chemical restraint and immobilization of primates, on various physiological parameters and blood gas values in cynomolgus... -
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- Functional Role of Serine Residues of Transmembrane Dopamin VII in Signal Transduction of CB2 Cannabinoid Receptor
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Rhee MH
- KMID: 1095120
- J Vet Sci.
- 2002 Sep;3(3):185-191.
Using site-directed mutagenesis technique, I have replaced serine 285 and serine 292 with the alanine, and assessed the binding of agonist and signaling such as the inhibition of adenylyl cyclase... -
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- Effects of MK-801 and Morphine on Spinal C-Fos Expression during the Development of Neuropathic Pain
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Lee YW, Park KA, Lee WT
- KMID: 1105109
- Yonsei Med J.
- 2002 Jun;43(3):370-376.
- doi: 10.3349/ymj.2002.43.3.370
The purpose of this study was to investigate the expression of c-fos in the spinal cord during the development of allodynia, induced by peripheral nerve injury. Following tight ligation of... -
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