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A Case of Sulfasalazine-Induced Hypersensitivity Syndrome Confirmed by Enzyme-Linked Immunospot Assay

Phatharacharukul P, Klaewsongkram J

A 24-year-old male with a history of spondyloarthropathy presented with high fever, cervical lymphadenopathy and generalized maculopapular rash. He was treated with prednisolone for chronic uveitis before being switched to...
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Optimal Timing of Zoster Vaccination After Shingles: A Prospective Study of the Immunogenicity and Safety of Live Zoster Vaccine

Lee E, Chun JY, Song KH, Choe PG, Bang JH, Kim ES, Kim HB, Park SW, Kim NJ, Park WB, Oh MD

BACKGROUND: Zoster vaccination is recommended for people with a history of herpes zoster (HZ), but the most effective timing of vaccine administration after zoster illness is unresolved. This prospective observational...
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Interferon-gamma Enzyme-Linked Immunospot Assay in Patients with Tuberculosis and Healthy Adults

Kim CH, Kim JY, Hwang YI, Lee CY, Choi JH, Park YB, Jang SH, Woo H, Kim DG, Lee MG, Hyun IG, Jung KS, Kim HS

  • KMID: 2320485
  • Tuberc Respir Dis.
  • 2014 Jan;76(1):23-29.
BACKGROUND: Interferon-gamma assays based on tuberculosis (TB)-specific antigens have been utilized for diagnosing and ruling out latent TB and active TB, but their utility is still limited for TB incidence...
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Accuracy of an Interferon-gamma Release Assay to Detect Active Tuberculosis in Children: A Pilot Study

Lee YJ, Chun P, We JH, Park SE

  • KMID: 2278963
  • Korean J Pediatr Infect Dis.
  • 2011 Jun;18(1):48-53.
PURPOSE: Early diagnosis of active tuberculosis (TB) in children is difficult. The widely used tuberculin skin test has low sensitivity and cross reactivity with non-tuberculous mycobacteria or Bacille Calmette-Guerin vaccination....
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Potential Role of Immunodiagnosis for Pulmonary Tuberculosis Using Induced Sputum Cells

Jeon D, Lee SE, Cho WH, Lee BH, Kim YS, Lee JE, Son ES, Lee YJ, Hong MS, Eum SY

PURPOSE: To evaluate the diagnostic utility and predictors for determinate results of an enzyme-linked immunospot assay using induced sputum cells (IS ELISPOT) for a rapid diagnosis of pulmonary tuberculosis (TB). MATERIALS...
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Immunological Prediction of Cytomegalovirus (CMV) Replication Risk in Solid Organ Transplantation Recipients: Approaches for Regulating the Targeted Anti-CMV Prevention Strategies

Han SH

The current cytomegalovirus (CMV) prevention strategies in solid organ transplantation (SOT) recipients have contributed towards overcoming the detrimental effects caused by CMV lytic infection, and improving the long-term success rate...
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Comparison of the Commercial QuantiFERON-CMV and Overlapping Peptide-based ELISPOT Assays for Predicting CMV Infection in Kidney Transplant Recipients

Kwon JS, Kim T, Kim SM, Sung H, Shin S, Kim YH, Shin EC, Kim SH, Han DJ

Cytomegalovirus (CMV) is one of the most important opportunistic infections in transplant recipients. Tests for CMV-specific T cell responses have been proposed to change the current risk stratification strategy using...
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Diagnostic Usefulness of Cytomegalovirus (CMV)-Specific T Cell Immunity in Predicting CMV Infection after Kidney Transplantation: A Pilot Proof-of-Concept Study

Kim SH, Lee HJ, Kim SM, Jung JH, Shin S, Kim YH, Sung H, Lee SO, Choi SH, Kim YS, Woo JH, Han DJ

BACKGROUND: Cytomegalovirus (CMV) is one of the most important opportunistic infections in transplant recipients. Currently sero-positivity for CMV IgG before solid organ transplantation is the laboratory test of choice for...
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Evaluation Methods for the Immunogenicity of Varicella and Zoster Vaccines

Park H

Varicella vaccine has been included in the national immunization program for children since 2005 and zoster vaccine has been released since 2012 in Korea. Even though both varicella and zoster...
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Analysis of cytomegalovirus-specific T-cell responses in patients with hypertension: comparison of assay methods and antigens

Youn JC, Kim JY, Jung MK, Yu HT, Park SH, Kim IC, Lee SK, Choi SW, Han S, Ryu KH, Park S, Shin EC

BACKGROUND: Recent studies suggest an association between cytomegalovirus (CMV) infection and hypertension. In the present study, we used a variety of antigens and different assay methods to investigate the relationship...
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Induction of Aspergillus fumigatus Specific T Cells using Dendritic Cells Pulsed with Asp f16 Recombinant Protein in vitro

Won HY, Kim EK, Sohn HJ, Shin WS, Min WS, Kim CC, Kim TG

  • KMID: 1574183
  • J Bacteriol Virol.
  • 2005 Dec;35(4):307-314.
Invasive aspergillosis is the most common Aspergillus fumigatus infection in immunocompromised patients. Although the treatment of the invasive aspergillosis has been mostly relied on antifungal agents, there still exists the...
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Alum Directly Modulates Murine B Lymphocytes to Produce IgG1 Isotype

Jin BR, Kim SJ, Lee JM, Kang SH, Han HJ, Jang YS, Seo GY, Kim PH

Aluminum hydroxide (alum) is the most widely used adjuvant in human vaccines. Nevertheless, it is virtually unknown whether alum acts on B cells. In the present study, we explored the...
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Immunogenicity and Safety of Oral Live Attenuated Salmonella typhi Vaccine

Oh MH, Shin DH, Pee DH, Shin YK, Choi BM, Sohn JW, Kim IS

  • KMID: 1808193
  • Infect Chemother.
  • 2004 Feb;36(1):11-17.
BACKGROUND: This study is aimed at evaluating immunogenicity by measuring immunoglobulin A (IgA) seroconversion rate through common mucosal immune system and adverse reactions after vaccination of oral live attenuated Salmonella...
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Measurement of HIV-1-specific T Cell Immunity by Using Recombinant Gag Protein

Jeong H, Wie SH, Kim YJ, Kim SI, Kim YR, Kim TG, Yang SH, Sung YC, Kang MW

  • KMID: 2285068
  • Infect Chemother.
  • 2006 Dec;38(6):374-382.
BACKGROUND: HIV-specific immunity, such as strong CD4+ helper and CD8+ cytotoxic T lymphocytes (CTL) responses, develops soon after HIV infection, but usually it can not control HIV replication which ultimately...
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Humoral and Cellular Immunogenicity Induced by Avian Influenza A (H7N9) DNA Vaccine in Mice

Choi EJ, Lee HS, Noh JY, Song JY, Cheong HJ, Shin OS, Lee H, Jeong M, Kim WJ

BACKGROUND: In March 2013, human infection with avian influenza A (H7N9) virus emerged in China, causing serious public health concerns and raising the possibility of avian-source pandemic influenza. Thus, the...
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Clinical applications of interferon-γ releasing assays for cytomegalovirus to differentiate cytomegalovirus disease from bystander activation: a pilot proof-of-concept study

Kim SH, Lee HS, Lee HJ, Kim SM, Shin S, Park SH, Kim KJ, Kim YH, Sung H, Lee SO, Choi SH, Yang SK, Kim YS, Woo JH, Han DJ

BACKGROUND/AIMS: We evaluated the proposed clinical application of the combined interpretation of host factors and viral factors in two different cytomegalovirus (CMV) co-infection models. METHODS: We prospectively enrolled all human immunodeficiency...
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The Effect of Antiglaucoma Medication on Cultured Human Conjunctival Epithelial Cells

Lee JK, Ryu YH

  • KMID: 2337460
  • J Korean Ophthalmol Soc.
  • 2006 Nov;47(11):1811-1818.
PURPOSE: To investigate the toxicity of a short-term application of timolol maleate, dorzolamide, and benzalkonium chloride (BAC) on human conjunctival epithelial cells in vitro. METHODS: Chang's conjunctival epithelial cell line...
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Kinetics of T-cell-based assays on cerebrospinal fluid and peripheral blood mononuclear cells in patients with tuberculous meningitis

Park KH, Lee MS, Lee SO, Choi SH, Kim YS, Woo JH, Kang JK, Lee SA, Kim SH

BACKGROUND/AIMS: The goal of this study was to monitor tuberculosis (TB)-specific T-cell responses in cerebrospinal fluid-mononuclear cells (CSF-MCs) and peripheral blood mononuclear cells (PBMCs) in patients with tuberculous meningitis (TBM)...
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Enhanced Induction of CEA Specific Tumor Immunity by TatCEA Fusion Protein

An CH, Kang WK, Oh ST, Cho HI, Kim TG

  • KMID: 2025797
  • J Korean Soc Coloproctol.
  • 2003 Jun;19(3):121-128.
PURPOSE: The human carcinoembryonic antigen (CEA) is expressed in several tumor types, including colorectal cancer, and is a tumor-associated antigen used as a target for antigen-specific immunotheraphy. CEA is a...
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Recombinant DNA and Protein Vaccines for Foot-and-mouth Disease Induce Humoral and Cellular Immune Responses in Mice

Bae JY, Moon SH, Choi JA, Park JS, Hahn BS, Kim KY, Kim B, Song JY, Kwon DH, Lee SC, Kim JB, Yang JS

BACKGROUND: Foot-and-mouth disease virus (FMDV) is a small single-stranded RNA virus which belongs to the family Picornaviridae, genus Apthovirus. It is a principal cause of FMD which is highly contagious...
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