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Extended-spectrum beta-Lactamases: Implications for the Clinical Laboratory and Therapy

Harada S, Ishii Y, Yamaguchi

Production of extended-spectrum beta-lactamase (ESBL) is one of the most important resistance mechanisms that hamper the antimicrobial treatment of infections caused by Enterobacteriaceae. ESBLs are classified into several groups according...
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Further Modification of the Modified Hodge Test for Detecting Metallo-beta-Lactamase-Producing Carbapenem-Resistant Enterobacteriaceae

Kim HK, Park JS, Sung H, Kim MN

BACKGROUND: The modified Hodge test (MHT) was designed to detect carbapenemase-producing Enterobacteriaceae (CPE). This study evaluated variables to improve the performance of MHT. METHODS: Carbapenem-resistant Enterobacteriaceae isolated from November 2010 to...
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Antimicrobial Resistance Surveillance of Bacteria in 1999 in Korea with a Special Reference to Resistance of Enterococci to Vancomycin and Gram-Negative Bacilli to Third Generation Cephalosporin, Imipenem, and Fluoroquinolone

Lee K, Lee HS, Jang SJ, Park AJ, Lee MH, Song WK, Chong YS, Members of Korean Nationwide Surveillance of Antimicrobial Resistance Group

The trend of antimicrobial resistance of bacteria isolated from patients in 30 Korean hospitals in 1999 was analyzed with a particular attention to cefotaxime- or fluoroquinolone-resistant gram-negative bacilli, imipenem-resistant Pseudomonas...
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Combined Use of the Modified Hodge Test and Carbapenemase Inhibition Test for Detection of Carbapenemase-Producing Enterobacteriaceae and Metallo-beta-Lactamase-Producing Pseudomonas spp.

Song W, Hong SG, Yong D, Jeong SH, Kim HS, Kim HS, Kim JS, Bae IK

BACKGROUND: We evaluated the combined use of the modified Hodge test (MHT) and carbapenemase inhibition test (CIT) using phenylboronic acid (PBA) and EDTA to detect carbapenemase-producing Enterobacteriaceae (CPE) and metallo-beta-lactamase...
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Prevalence and Molecular Characteristics of Carbapenemase-Producing Enterobacteriaceae From Five Hospitals in Korea

Jeong SH, Kim HS, Kim JS, Shin DH, Kim HS, Park MJ, Shin S, Hong JS, Lee SS, Song W

BACKGROUND: The emergence of carbapenemase-producing Enterobacteriaceae (CPE) represents a major clinical problem because these bacteria are resistant to most antibiotics. CPE remain relatively uncommon in Korea. We report the prevalence,...
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Xpert CARBA-R Assay for the Detection of Carbapenemase-Producing Organisms in Intensive Care Unit Patients of a Korean Tertiary Care Hospital

Kim DK, Kim HS, Pinto N, Jeon J, D'Souza R, Kim MS, Choi JY, Yong D, Jeong SH, Lee K

Carbapenemase-producing organisms (CPO) are rapidly disseminating worldwide, and their presence in tertiary care hospitals poses a significant threat to the management of nosocomial infections. There is a need to control...
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Chemopreventive and metabolic effects of inulin on colon cancer development

Hijova E, Szabadosova V, Stofilova , Hrckova G

Prebiotics modulate microbial composition and ensure a healthy gastrointestinal tract environment that can prevent colon cancer development. These natural dietary compounds are therefore potential chemopreventive agents. Thirty Sprague-Dawley rats (4...
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