- Hair growth promoting effects of emodin in telogenic C57BL/6 mice
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Yon JM, Park SG, Lin C, Gwon LW, Lee JG, Baek IJ, Lee BJ, Yun YW, Nam SY
- KMID: 2368750
- Korean J Vet Res.
- 2016 Jun;56(2):97-101.
- doi: 10.14405/kjvr.2016.56.2.97
Emodin is an anthraquinone derivative from the roots of Rheum officinale Baill that possesses a variety of biological activities, including inhibition of 5α-reductase and prostaglandin D2. In this study, we... -
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- Emodin exerts protective effect against palmitic acid-induced endoplasmic reticulum stress in HepG2 cells
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Thomas SS, Park S, Cha YS, Kim KA
- KMID: 2444941
- J Nutr Health.
- 2019 Apr;52(2):176-184.
- doi: 10.4163/jnh.2019.52.2.176
PURPOSE: Protein overloading in the endoplasmic reticulum (ER) leads to endoplasmic reticulum stress, which exacerbates various disease conditions. Emodin, an anthraquinone compound, is known to have several health benefits. The... -
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- Emodin ameliorates high-glucose induced mesangial p38 over-activation and hypocontractility via activation of PPARgamma
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Liu Y, Jia L, Liu ZC, Zhang H, Zhang PJ, Wan Q, Wang R
- KMID: 756208
- Exp Mol Med.
- 2009 Sep;41(9):648-655.
- doi: 10.3858/emm.2009.41.9.071
Early stage diabetic nephropathy is characterized by elevated glomerular filtration. Recent studies have identified high-glucose induced p38 MAPK (p38) over-activation in mesangial cells. Mesangial hypocontractility is the major underlying mechanism,... -
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- Intestinal absorption of aloin, aloe-emodin, and aloesin; A comparative study using two in vitro absorption models
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Park MY, Kwon HJ, Sung MK
- KMID: 2313371
- Nutr Res Pract.
- 2009 Mar;3(1):9-14.
Aloe products are one of the top selling health-functional foods in Korea, however the adequate level of intake to achieve desirable effects are not well understood. The objective of this... -
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- Assessment of the Purity of Emodin by Quantitative Nuclear Magnetic Resonance Spectroscopy and Mass Balance
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Park S, Choi YJ, Do GH, Seo EK, Hyun S, Lee D
- KMID: 2459963
- Nat Prod Sci.
- 2019 Sep;25(3):222-227.
- doi: 10.20307/nps.2019.25.3.222
Quantitative nuclear magnetic resonance (qNMR) is a well-established method adopted by international pharmacopoeia for quantitative and purity analyses. Emodin is a type of anthraquinone, well known as the main active... -
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- Emodin prevents intima thickness via Wnt4/Dvl-1/beta-catenin signaling pathway mediated by miR-126 in balloon-injured carotid artery rats
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Hua JY, He YZ, Xu Y, Jiang XH, Ye W, Pan ZM
- KMID: 2155424
- Exp Mol Med.
- 2015 Jun;47(6):e170.
- doi: 10.1038/emm.2015.36
Neointimal proliferation after vascular injury is a key mechanism of restenosis, a major cause of percutaneous transluminal angioplasty failure and artery bypass occlusion. Emodin, an anthraquinone with multiple physiological activities,... -
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- Emodin Isolated from Polygoni cuspidati Radix Inhibits TNF-alpha and IL-6 Release by Blockading NF-kappaB and MAP Kinase Pathways in Mast Cells Stimulated with PMA Plus A23187
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Lu Y, Jeong YT, Li X, Kim MJ, Park PH, Hwang SL, Son JK, Chang HW
- KMID: 2170660
- Biomol Ther.
- 2013 Nov;21(6):435-441.
Emodin, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, has several beneficial pharmacologic effects, which include anti-cancer, anti-diabetic, and anti-inflammatory activities. In this study, the authors examined the... -
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- Inhibition of tamoxifen's therapeutic effects by emodin in estrogen receptor-positive breast cancer cell lines
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Kim YG, Park YH, Yang EY, Park WS, Park KS
- KMID: 2461898
- Ann Surg Treat Res.
- 2019 Nov;97(5):230-238.
- doi: 10.4174/astr.2019.97.5.230
PURPOSE: This study was aimed to investigate the combination effect of endoxifen and emodin on estrogen receptor (ER) positive breast cancer cell lines and to explain the mechanism of the... -
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- Anti-Helicobacter pylori Compounds from Polygonum cuspidatum
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Khalil AA, Park WS, Kim HJ, Akter KM, Ahn MJ
- KMID: 2355149
- Nat Prod Sci.
- 2016 Sep;22(3):220-224.
- doi: 10.20307/nps.2016.22.3.220
Anti-Helicobacter pylori activity guided fractionation led to the isolation of five anthraquinones, two stilbenes and one naphthoquinone from the EtOAc fraction of Polygonum cuspidatum, using silica gel column chromatography, Sephadex-LH20,... -
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- Plasma, tissue and urinary levels of aloin in rats after the administration of pure aloin
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Park MY, Kwon HJ, Sung MK
- KMID: 2313344
- Nutr Res Pract.
- 2008 Mar;2(1):17-21.
Aloin is a physiologically active anthraquinone present in aloe. There are two isomers of aloin, aloin A and aloin B, occurring as a mixture of diastereomers. The objective of this... -
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- Single- and repeated-dose toxicities of aloe fermentation products in rats
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Cho JH, Kim HK, Baik SO, Choi SY, Lee JY
- KMID: 1850051
- Lab Anim Res.
- 2011 Sep;27(3):235-244.
- doi: 10.5625/lar.2011.27.3.235
In this study, aloe fermentation products were derived from mycelia from 3 mushrooms: Ganoderma lucidum (AG), Hericium erinaceum (AH), and Phellinus linteus (AP). Levels of aloin A and B increased... -
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