- Studies on efficacy and dosage for schoolchildren of some anthelminthic drugs
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Chu JK, Cho YJ
- KMID: 1384294
- Korean J Parasitol.
- 1974 Dec;12(2):147-156.
- doi: 10.3347/kjp.1974.12.2.147
The evaluation of the effects of anthelmintic drug dose was done by the eggs reduction and the eggs negative conversion rate. The drug dose according to the age of the... -
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- Eribulin for Advanced Breast Cancer: A Drug Evaluation
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Shablak A
- KMID: 2374539
- J Breast Cancer.
- 2013 Mar;16(1):12-15.
Eribulin is a synthetic microtubule dynamics inhibitor that was developed from a marine natural product halichondrin B. It exhibited in vitro and in vivo activities against a wide number of... -
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- Rethinking Statistical Approaches to Evaluating Drug Safety
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Liu JP
- KMID: 1786203
- Yonsei Med J.
- 2007 Dec;48(6):895-900.
- doi: 10.3349/ymj.2007.48.6.895
PURPOSE: The current methods used to evaluate the efficacy of drug products are inadequate. We propose a non-inferiority approach to prove the safety of drugs. MATERIALS AND METHODS: Traditional... -
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- Central Nervous System Drug Evaluation Using Positron Emission Tomography
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Sekine M, Maeda J, Shimada H, Nogami T, Arakawa R, Takano H, Higuchi M, Ito H, Okubo Y, Suhara T
- KMID: 2171280
- Clin Psychopharmacol Neurosci.
- 2011 Apr;9(1):9-16.
In conventional pharmacological research in the field of mental disorders, pharmacological effect and dose have been estimated by ethological approach and in vitro data of affinity to the site of... -
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- Stem Cells in Drug Screening for Neurodegenerative Disease
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Kim HJ, Jin CY
- KMID: 2285433
- Korean J Physiol Pharmacol.
- 2012 Feb;16(1):1-9.
- doi: 10.4196/kjpp.2012.16.1.1
Because the average human life span has recently increased, the number of patients who are diagnosed with neurodegenerative diseases has escalated. Recent advances in stem cell research have given us... -
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- Enhanced Chemotherapeutic Drug Delivery to Tumor Tissue by High Intensity Focused Ultrasound
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Jung JT, Lee DH, Hwang JH
- KMID: 783156
- Korean J Gastroenterol.
- 2009 Apr;53(4):216-220.
Cancer is the first leading cause of death in Korea. Systemic chemotherapy is currently the standard treatment for a wide variety of cancers; however, in the majority of cases, cure... -
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- Correlative Effect between in vivo Hollow Fiber Assay and Xenografts Assay in Drug Screening
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Lee KH, Rhee KH
- KMID: 2270839
- Cancer Res Treat.
- 2005 Jun;37(3):196-200.
PURPOSE: This study was carried out to assess the usage of an in vivo hollow fiber assay to screen drugs with highly predictive accuracy. MATERIALS AND METHODS: The assay systems... -
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- Establishment and Significance of Bioequivalence Recommendations for Individual Products-Drugs Acting on Circulatory System and Others
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Bae SH, Zheng YF, Kwon MJ, Choi EJ, Bae SK
- KMID: 2334541
- J Korean Soc Clin Pharmacol Ther.
- 2013 Jun;21(1):17-25.
Along with the enactment of a law separating the prescribing and dispensing of drugs in Korea in 2000, attempts at reducing medical expenses by generic substitution have been allowed since... -
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- Availability of Toxicologic Screening Tests in the Emergency Department
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Um IK, Park JS, Han KS, Cho H, Choi SH, Lee SW, Hong YS
- KMID: 2203634
- J Korean Soc Clin Toxicol.
- 2011 Jun;9(1):26-29.
PURPOSE: The role of a point of care test (POCT) is currently becoming important when treating patients and making decisions in the emergency department. It also plays a role for... -
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- Modeling of Human Genetic Diseases Via Cellular Reprogramming
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Kang MY, Suh JH, Han YM
- KMID: 1428896
- J Genet Med.
- 2012 Dec;9(2):67-72.
- doi: 10.5734/JGM.2012.9.2.67
The generation of induced pluripotent stem cells (iPSCs) derived from patients' somatic cells provides a new paradigm for studying human genetic diseases. Human iPSCs which have similar properties of human... -
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- In Vitro Infectivity Assessment by Drug Susceptibility Comparison of Recombinant Leishmania major Expressing Enhanced Green Fluorescent Protein or EGFP-Luciferase Fused Genes with Wild-Type Parasite
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Sadeghi S, Seyed N, Etemadzadeh MH, Abediankenari S, Rafati S, Taheri T
- KMID: 2381755
- Korean J Parasitol.
- 2015 Aug;53(4):385-394.
- doi: 10.3347/kjp.2015.53.4.385
Leishmaniasis is a worldwide uncontrolled parasitic disease due to the lack of effective drug and vaccine. To speed up effective drug development, we need powerful methods to rapidly assess drug... -
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- Microfluidic System Based High Throughput Drug Screening System for Curcumin/TRAIL Combinational Chemotherapy in Human Prostate Cancer PC3 Cells
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An D, Kim K, Kim J
- KMID: 2170631
- Biomol Ther.
- 2014 Jul;22(4):355-362.
We have developed a fully automated high throughput drug screening (HTDS) system based on the microfluidic cell culture array to perform combinational chemotherapy. This system has 64 individually addressable cell... -
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- Clinical and pharmacological application of multiscale multiphysics heart simulator, UT-Heart
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Okada JI, Washio T, Sugiura S, Hisada T
- KMID: 2455805
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):295-303.
- doi: 10.4196/kjpp.2019.23.5.295
A heart simulator, UT-Heart, is a finite element model of the human heart that can reproduce all the fundamental activities of the working heart, including propagation of excitation, contraction, and... -
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- Analysis of the Contributions of Original Articles in Major Dermatology Journals in Korea
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Cho HM, Ahn HH
- KMID: 2302210
- Korean J Dermatol.
- 2007 May;45(5):439-444.
BACKGROUND: The Korean Journal of Dermatology and the Annals of Dermatology are representative journals of dermatology in Korea. Evaluation of their content, authors and affiliations are valuable for our understanding... -
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- Recent Advances for Enhancing Drug Metabolizing Functions of Hepatocyte-like Cells Derived from Human Pluripotent Stem Cells
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Han J, Kim JH
- KMID: 2129472
- Hanyang Med Rev.
- 2015 Nov;35(4):196-206.
- doi: 10.7599/hmr.2015.35.4.196
Hepatocyte-like cells (HLCs) derived from human pluripotent stem cells are a promising cell source for drug screening and toxicity tests. Thus, various hepatic differentiating protocols have been developed, leading to... -
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- Mesenchymal stem cells in acute myeloid leukemia: a focus on mechanisms involved and therapeutic concepts
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Fathi E, Sanaat Z, Farahzadi
- KMID: 2459381
- Blood Res.
- 2019 Sep;54(3):165-174.
- doi: 10.5045/br.2019.54.3.165
Drug resistance in cancer, especially in leukemia, creates a dilemma in treatment planning. Consequently, studies related to the mechanisms underlying drug resistance, the molecular pathways involved in this phenomenon, and... -
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- Induced Pluripotent Stem Cells as a Novel Tool in Psychiatric Research
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Kim S, Kim MK, Oh D, Lee SH, Kim B
- KMID: 2316592
- Psychiatry Investig.
- 2016 Jan;13(1):8-17.
- doi: 10.4306/pi.2016.13.1.8
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) provides a valuable opportunity to study neurodevelopmental and neurodegenerative psychiatric diseases by offering an unlimited source for patient-specific neuronal and... -
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- Gabapentin as a Adjuvant Analgesic in Central Pain Syndrome
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Han TH, Kwon MA
- KMID: 2091574
- Korean J Anesthesiol.
- 2000 Dec;39(6):834-841.
- doi: 10.4097/kjae.2000.39.6.834
BACKGROUND: This study was undertaken to investigate the analgesic efficacy and safety of gabapentin in central pain syndrome. METHODS: With a diagnosis of central pain syndrome, a total 24 patients... -
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- Relationship between In Vitro Chemosensitivity assessed with MTT Assay and Clinical Outcomes in 103 Patients with Acute Leukemia
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Jun KR, Jang S, Chi HS, Lee KH, Lee JH, Choi SJ, Seo JJ, Moon HN, Im HJ, Park CJ
- KMID: 1781465
- Korean J Lab Med.
- 2007 Apr;27(2):89-95.
- doi: 10.3343/kjlm.2007.27.2.89
BACKGROUND: Cellular drug resistance is supposed to play a major role in chemotherapy failure or relapse. The purpose of this study was to analyze the relationship between in vitro... -
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- Comparison of anticancer drug efficacy using the short-term microplate culture and MTT dye reduction assay
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Kim NK, Lee KR, Hwang PH, Kim JS
- KMID: 2042041
- J Korean Pediatr Soc.
- 1993 Oct;36(10):1426-1433.
Individual tumors, even those of the same histologic type, show varying sensitivity to specific cytotoxic agent. Therefore, sensitivity testing assume an increasingly important as an orientational aid in planning chemotherapy.... -
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