- DNAse I hypersensitive sites of lung specific transcription factor gene
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Lee YC
- KMID: 2160239
- Tuberc Respir Dis.
- 2000 Jun;48(6):879-886.
- doi: 10.4046/trd.2000.48.6.879
BACKGROUND: Thyroid Transcription Factor-1(TTF-1) acts as a tissue specific transcription factor in the regulation of lung specific gene expression and as morphogenic protein during lung organogenesis. Currently, there is very... -
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- The Effect of A Potent Calcium Channel Blocker, Nifedipine, on the Castration-induced Apoptosis of the Rat Ventral Prostate
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Han CH, Rhee HW, Kang SH
- KMID: 2290098
- Korean J Urol.
- 1997 Sep;38(9):905-911.
The rapid involution of the rat ventral prostate after castration is an active process initiated by removal of the inhibitory effects of androgen on prostatic cell death. The degradation of... -
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- Applications of CRISPR/Cas9 for Gene Editing in Hereditary Movement Disorders
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Im W, Moon J, Kim M
- KMID: 2353874
- J Mov Disord.
- 2016 Sep;9(3):136-143.
- doi: 10.14802/jmd.16029
Gene therapy is a potential therapeutic strategy for treating hereditary movement disorders, including hereditary ataxia, dystonia, Huntington's disease, and Parkinson's disease. Genome editing is a type of genetic engineering in... -
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- Mutations of DNA repair associated gene, APEX in human colorectal cancer
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Oh SH, Park HB, Kim YJ
- KMID: 2052793
- Exp Mol Med.
- 1997 Sep;29(3):165-170.
Structural and functional changes in the major apurinic/apyrimidinic DNA endonuclease (APEX) gene in human colorectal cancers were investigated. DNAs were prepared from surgically removed 25 human colorectal tissues and direct... -
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- Construction of a New T-Vector: Nickase (Nt.BspQI)-Generated T-Vector Bearing a Reddish-Orange Indicator Gene
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Choi JY, Jo C, Jo SA
- KMID: 2360868
- Tissue Eng Regen Med.
- 2016 Feb;13(1):66-69.
- doi: 10.1007/s13770-015-0118-z
T-vectors are widely used for cloning the polymerase chain reaction (PCR) products. However, the low conversion efficiency of a plasmid into the linear T-vector usually results in non-recombinants. Here, we... -
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- Genome Editing Using Engineered Nucleases
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Shin JH, Kim H
- KMID: 2162812
- J Korean Orthop Res Soc.
- 2015 Dec;18(2):60-73.
- doi: 10.0000/jkors.2015.18.2.60
Genome editing is a useful research tool essentially applicable to gene therapy in the field of biotechnology, pharmaceutics and medicine. Scientists have developed three types of programmable nucleases for genome... -
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- Isolation of a Partial Human cDNA Encoding a Factor Binding to the Perfect Palindrome of Enhancer A of HLA Class I Promoter, Homologous to NF-kB2
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Park JH, Lee TJ, Kim SJ
- KMID: 1551643
- J Korean Soc Microbiol.
- 1998 Jun;33(3):295-306.
Genes encoding sequence-specific DNA binding proteins have been isolated by screening cDNA libraries constructed in rgt11 expression vector with recognition site DNAs. We isolated a rgt11 recombinant human cDNA clone,... -
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- Understanding Epistatic Interactions between Genes Targeted by Non-coding Regulatory Elements in Complex Diseases
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Sung MK, Bang H, Choi JK
- KMID: 2391494
- Genomics Inform.
- 2014 Dec;12(4):181-186.
- doi: 10.5808/GI.2014.12.4.181
Genome-wide association studies have proven the highly polygenic architecture of complex diseases or traits; therefore, single-locus-based methods are usually unable to detect all involved loci, especially when individual loci exert... -
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- Purification and refolding of the recombinant subunit B protein of the Aggregatibacter actinomycetemcomitans cytolethal distending toxin
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Jeon YS, Seo SC, Kwon JH, Ko SY, Kim HS
- KMID: 1486869
- J Korean Acad Periodontol.
- 2008 Aug;38(Suppl):343-354.
- doi: 10.5051/jkape.2008.38.Suppl.343
PURPOSE: Aggregatibacter actinomycetemcomitans is associated with localized aggressive periodontitis. It produces cytolethal distending toxin (CDT), which induces cell cycle arrest in the G2/M phase. The CDT holotoxin is composed of... -
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- IL-10 Plasmid DNA Delivery in NOD Mice for the Prevention of Autoimmune Pancreatic Beta Cell Destruction
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Koh JJ, Ko KS, Park JS, Kim WB, Park KS, Kim SY, Lee HK, Shin SG, Kim SW
- KMID: 2199619
- J Korean Soc Endocrinol.
- 2000 Jun;15(2):262-271.
BACKGROUND: Recently, we have reported that biodegradable poly [-(4-aminobutyl)-L-glycolic acid] (PAGA) can condense and protect plasmid DNA from DNase I. In this study, we investigated whether the systemic administration of... -
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- Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity
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Yoon SP, Kim J
- KMID: 2353341
- Anat Cell Biol.
- 2016 Sep;49(3):165-176.
- doi: 10.5115/acb.2016.49.3.165
Enhanced oxidative stress is a hallmark of cisplatin nephrotoxicity, and inhibition of poly(ADP-ribose) polymerase 1 (PARP1) attenuates oxidative stress during cisplatin nephrotoxicity; however, the precise mechanisms behind its action remain... -
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- Autologous Vs Allogenic Chondrocytes Transplantation for Full Thickness Chondral Defects in Rabbit's Patella
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Jahng JS, Lee JW, Yang WI
- KMID: 2105306
- J Korean Orthop Assoc.
- 1998 Apr;33(2):433-444.
Biologic resurfacing of the damaged joints is an area of great interest and clinical promise because of the limited potential ofdamaged articular cartilage healing. Several methods such as spongiolization. joint... -
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- Mechanism of Azaline B-induced Apoptosis of Ventral Prostate in Rat
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Park C, Nam SI, Yun EJ, Park JI, Lee JH, Park SK, Hwang BD, Lim K
- KMID: 2293576
- Korean J Urol.
- 2003 Nov;44(11):1157-1166.
PURPOSE: Androgen deprivation triggers a sequence of events that activates apoptotic cell death of the androgen-dependent epithelial cells within the rat ventral prostate, ultimately resulting in the involution of the... -
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- Transcriptional Regulation of H2B Histone Gene Expression by Nocodazole in HL-60 Cells
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Lim K, Hong YG, Lee MS, Son MY, Yun KA, Park JI, Yoon WH, Park SK, Hwang BD
- KMID: 2175113
- J Korean Cancer Assoc.
- 2000 Apr;32(2):407-416.
PURPOSE: Nocodazole, a microtubule disrupting reagent, is known to arrest cells in the M phase, To gain insight on the regulatory mechanism of H2B histone gene expression by nocodazole in HL-60 cell,... -
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- Flow Cytometric Analysis of Cultured Adult Neural Stem Cells from Guinea Pig Spiral Ganglion
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Kim YH, Kim CH, Park KH, Park SN, Choi MY, Hong OK, Kim JH, Cho SJ, Kim JH, Chang KH, Yeo SW
- KMID: 2276985
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2009 Feb;52(2):129-133.
- doi: 10.3342/kjorl-hns.2009.52.2.129
BACKGROUND AND OBJECTIVES: To make stem cell therapy successful as one of treatment options for sensorineural hearing loss, it is essential to culture and obtain sufficient amounts of adult neural... -
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- Mechanism of Castration-induced Apoptosis of Ventral Prostate in Rat
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Park C, Park JI, Yun EJ, Song KS, Kim JS, Kim YR, Lee SD, Park SK, Hwang BD, Lim K
- KMID: 2200563
- J Korean Soc Endocrinol.
- 2005 Jun;20(3):230-241.
- doi: 10.3803/jkes.2005.20.3.230
BACKGROUNDS: Castration-induced androgen deprivation triggers a sequence of events, which activates apoptotic cell death of the androgen-dependent epithelial cells within the rat ventral prostate. To investigate the mechanism of castration-dependent... -
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- Adaptive Change of AP DNA Endonuclease Against Genotoxic Agents in Normal and Transformed Cells
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Lee YH, Jeong IC, Oh SH, Cho MY
- KMID: 2175139
- J Korean Cancer Assoc.
- 1999 Dec;31(6):1271-1278.
PURPOSE: AP DNA endonuclease (APE), an enzyme responsible for the repair of damaged DNAs, is essential for the maintenance of genetic information of cells. Deficiency of APE in certain hereditary... -
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- Mechanism of Azaline B-induced Apoptosis in Rat Testis
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Park C, Yun EJ, Song KS, Kim YR, Kim JS, Lee SD, Park JI, Lee JH, Park SK, Hwang BD, Lim K
- KMID: 2293996
- Korean J Urol.
- 2005 Jul;46(7):750-760.
PURPOSE: To identify the mechanism of azaline B-dependent apoptosis, the regulation of Fas and FasL genes has been investigated. MATERIALS AND METHODS: Azaline B was subcutaneously injected into Sprague-Dawley rats. The... -
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- Comparative Evaluation of Three Homogenization Methods for Isolating Middle East Respiratory Syndrome Coronavirus Nucleic Acids From Sputum Samples for Real-Time Reverse Transcription PCR
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Sung H, Yong D, Ki CS, Kim JS, Seong MW, Lee H, Kim MN
- KMID: 2373576
- Ann Lab Med.
- 2016 Sep;36(5):457-462.
- doi: 10.3343/alm.2016.36.5.457
BACKGROUND: Real-time reverse transcription PCR (rRT-PCR) of sputum samples is commonly used to diagnose Middle East respiratory syndrome coronavirus (MERS-CoV) infection. Owing to the difficulty of extracting RNA from sputum... -
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- Effects of estrogen receptor and estrogen on the chromatin structure in estrogen receptor stable transfectants
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Lee YJ, Lim WC, Jin YH, Lee SK
- KMID: 1081457
- Exp Mol Med.
- 2002 May;34(2):95-99.
The estrogen receptor (ER), a member of the nuclear hormone receptor superfamily recruits coactivators that modify local chromatin structure. Here we investigated the effect of the estrogen receptor and estrogen... -
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