- Towards the Application of Human Defensins as Antivirals
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Park MS, Kim JI, Lee I, Park S, Bae JY, Park MS
- KMID: 2421733
- Biomol Ther.
- 2018 May;26(3):242-254.
- doi: 10.4062/biomolther.2017.172
Defensins are antimicrobial peptides that participate in the innate immunity of hosts. Humans constitutively and/or inducibly express α- and β-defensins, which are known for their antiviral and antibacterial activities. This... -
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- The Expression of Human Beta Defensins by Thermal Injury
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Jeong HS, Yeon CJ, Lee JS
- KMID: 1439461
- J Korean Burn Soc.
- 2012 Jun;15(1):39-44.
PURPOSE: Defensins are important components of innate immune system. These peptides have antimicrobial activity against a wise variety of pathogens that associated with burn wound infection. In particular, human beta-defensins... -
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- Expression of beta Defensins in the Human Middle Ear Mucosa
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Moon SK, Lim DJ
- KMID: 2276095
- Korean J Otolaryngol-Head Neck Surg.
- 2004 Feb;47(2):103-107.
BACKGROUND AND OBJECTIVES: It is believed that the innate immunity plays a critical role in protecting the tubotympanum from being infected because the middle ear cavity is normally sterile despite... -
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- Expression of Human Beta-Defensin in Human Male Urogenital Organs
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Chang IH, Yum SH, Myung SC, Kim YS
- KMID: 2248677
- Korean J Infect Dis.
- 2001 Aug;33(4):233-241.
BACKGROUND: Defensins are small (3.5~5 kDa) cationic antimicrobial peptides that have a broad spectrum of activity that includes gram-negative bacterias, yeasts and enveloped viruses. The defensins contain six cysteine residues... -
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- Cross-Regulation of Innate and Adaptive Immunity: A New Perspective for the Pathogenesis of Inflammatory Bowel Disease
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Oh DY, Koh SJ
- KMID: 2155636
- Gut Liver.
- 2015 May;9(3):263-264.
- doi: 10.5009/gnl15123
No abstract available. -
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- Modulation of the Host Antimicrobial Peptide (Human beta-defensin-1, -2) Expression of Vaginal Squamous Epithelial Cells with using 17beta-Estradiol and Progesterone
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Kim MS, Kim YC, Kim SC, Myung SC
- KMID: 1997113
- Korean J Urol.
- 2007 Apr;48(4):439-443.
- doi: 10.4111/kju.2007.48.4.439
PURPOSE: In mammals, alphaand beta-defensins are antimicrobial peptides that are expressed in various epithelial and phagocytic cells. Human beta-defensin-1 and -2 (hBD-1, hBD-2) have recently been shown to be expressed... -
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- The Expression of beta-defensin 1 in Various Skin Tumors
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Cho HK, Whang KU, Park YL, Lee JS
- KMID: 1427401
- Korean J Dermatol.
- 2013 Aug;51(8):586-592.
BACKGROUND: Among antimicrobial peptides produced by keratinocytes, beta-defensins and LL-37 are the major human antimicrobial peptides. Because beta-defensins have recently received great attention for its roles associated with host defense... -
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- Molecular Defense Mechanisms during Urinary Tract Infection
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Choi SY, Chang IH
- KMID: 2319429
- Urogenit Tract Infect.
- 2015 Oct;10(2):57-66.
- doi: 10.14777/uti.2015.10.2.57
The urinary tract is a common site of infection. The complete mechanisms of urinary tract infection (UTI) are still unknown. In general, the strategies of the uropathogenic Escherichia coli are... -
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- Ultrastructural immunolocalization of beta-defensin-27 in granulocytes of the dermis and wound epidermis of lizard suggests they contribute to the anti-microbial skin barrier
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Alibardi L
- KMID: 2046765
- Anat Cell Biol.
- 2013 Dec;46(4):246-253.
- doi: 10.5115/acb.2013.46.4.246
The high resistance to infections in lizard wounds suggests that these reptiles possess effective antimicrobial peptides in their tissues. The present immunocytochemical study shows the cellular localization of beta-defensin 27... -
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- Expression of Human beta-defensin mRNA in Epidermal Proliferative Diseases
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Kim YJ, Choi YK, Kim MN, Hong CK, Ro BI, Seo SJ
- KMID: 2302992
- Korean J Dermatol.
- 2003 May;41(5):551-558.
BACKGROUND: Defensins are cationic antimicrobial peptides with a wide range of antimicrobial activity against gram positive and gram negative bacteria, yeasts, fungi, and viruses. They are also believed to promote... -
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- Current Opinions Regarding Defense Mechanisms during Urinary Tract Infection
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Kim JH, Kwon JK, Chang IH
- KMID: 1502110
- Korean J Urogenit Tract Infect Inflamm.
- 2013 Oct;8(2):63-72.
- doi: 10.14777/kjutii.2013.8.2.63
Mucosal tissues in the gastrointestinal tract are exposed to a significant number of microorganisms, many of which present a danger to the host. In contrast, the urogenital tract is colonized... -
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- Expression and clinical significance of defensin alpha 6 in colorectal cancer
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Park S, Ahn T, Lee H, Jeong DJ, Jeong HI, Son MW, Lee MS, Baek MJ
- KMID: 2369129
- Korean J Clin Oncol.
- 2016 Dec;12(2):78-82.
- doi: 10.14216/kjco.16013
PURPOSE: Defensin alpha 6 (DEFA6) is cationic short peptide with known functional activities in innate antimicrobial immunity. DEFA6 is also highly expressed in colorectal cancer tissue. The mechanism and function... -
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- Vitamin D, the Cutaneous Barrier, Antimicrobial Peptides and Allergies: Is There a Link?
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Roider E, Ruzicka T, Schauber J
- KMID: 2260330
- Allergy Asthma Immunol Res.
- 2013 May;5(3):119-128.
- doi: 10.4168/aair.2013.5.3.119
Atopic diseases such as atopic dermatitis (AD) are very common in industrialized countries. Up to 15%-30% of all children and 2%-10% of all adults suffer from AD. Already in early... -
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- Effects of Stress on Mouse beta-Defensin-3 Expression in the Upper Digestive Mucosa
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Kawashima , Shimizu T, To M, Saruta J, Jinbu Y, Kusama M, Tsukinoki
- KMID: 2386467
- Yonsei Med J.
- 2014 Mar;55(2):387-394.
PURPOSE: Gastrointestinal integrity and immune surveillance are affected by stress. Stress also adversely affects mucosal barrier function. beta-defensins constitute an integral component of the innate immune system as antimicrobial peptides,... -
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- The Relaxing Effect of alpha-Defensin 1 on the Adrenergic Responses of Rat Bladder
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Lee SY, Kim DK, Kim KD, Myung SC, Lee MY
- KMID: 1448917
- Korean J Physiol Pharmacol.
- 2011 Jun;15(3):143-147.
- doi: 10.4196/kjpp.2011.15.3.143
Defensins, cysteine-rich cationic polypeptides released from neutrophils, are known to have powerful antimicrobial properties. In this study, we sacrificed 30 rats to investigate the effects of alpha-defensin 1 on detrusor... -
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- Conservation of Mucous Epithelial Characteristics in the Human Middle Ear Epithelial Cell Line
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Moon SK, Lee J, Choung YH, Park K, Lim DJ
- KMID: 2276131
- Korean J Otolaryngol-Head Neck Surg.
- 2004 Apr;47(4):299-303.
BACKGROUND AND OBJECTIVES: The stable cell line system of middle ear epithelial cells is essential for studying molecular pathogenesis of otitis media. Recently, we succeeded in establishing the human middle... -
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- Expression of TIM-3, Human beta-defensin-2, and FOXP3 and Correlation with Disease Activity in Pediatric Crohn's Disease with Infliximab Therapy
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Kim MJ, Lee WY, Choe YH
- KMID: 2155645
- Gut Liver.
- 2015 May;9(3):370-380.
- doi: 10.5009/gnl13408
BACKGROUND/AIMS: This study investigated the expression of T cell immunoglobulin- and mucin-domain-containing molecule 3 (TIM-3), human beta-defensin (HBD)-2, forkhead box protein 3 (FOXP3), and the frequency of CD4+ CD25+ FOXP3+... -
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- Beta-Defensin 124 Is Required for Efficient Innate Immune Responses in Prostate Epithelial RWPE-1 Cells
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Kim KH, Lee J, Han JH, Myung SC
- KMID: 1885622
- Korean J Urol.
- 2014 Jun;55(6):417-425.
- doi: 10.4111/kju.2014.55.6.417
PURPOSE: The present study aimed to determine the role played by beta-defensin 124 (DEFB124) in the innate immunity of prostate epithelial RWPE-1 cells during bacterial infection. MATERIALS AND METHODS: The expression... -
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- Human beta-defensin 2 is induced by interleukin-1b in the cornealepithelial cells
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Shin JS, Kim CW, Kwon YS, Kim JC
- KMID: 1097101
- Exp Mol Med.
- 2004 Jun;36(3):204-210.
Mammalian epithelia produce the various antimicrobial peptides against the bacterial or viral infection, thereby acting as the active immune modulators in the innate immunity. In this study, we examined the... -
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- Expression and Modulation of LL-37 in Normal Human Keratinocytes, HaCaT cells, and Inflammatory Skin Diseases
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Kim JE, Kim BJ, Jeong MS, Seo SJ, Kim MN, Hong CK, Ro BI
- KMID: 1712748
- J Korean Med Sci.
- 2005 Aug;20(4):649-654.
- doi: 10.3346/jkms.2005.20.4.649
Defensins and cathelicidins (LL-37) are major antimicrobial peptides (AMPs) of the innate immune system of the human skin. In normal non-inflamed skin these peptides are negligible, but their expression can... -
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