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Transposable Elements: No More 'Junk DNA'

Kim YJ, Lee J, Han K

Since the advent of whole-genome sequencing, transposable elements (TEs), just thought to be 'junk' DNA, have been noticed because of their numerous copies in various eukaryotic genomes. Many studies about...
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Foldback Intercoil DNA and the Mechanism of DNA Transposition

Kim BD

Foldback intercoil (FBI) DNA is formed by the folding back at one point of a non-helical parallel track of double-stranded DNA at as sharp as 180degrees and the intertwining of...
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Transposable Elements and Genome Size Variations in Plants

Lee SI, Kim NS

Although the number of protein-coding genes is not highly variable between plant taxa, the DNA content in their genomes is highly variable, by as much as 2,056-fold from a 1C...
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Identification of hRad21-Binding Sites in Human Chromosome

Chin C, Chung BS

  • KMID: 2166189
  • Genomics Inform.
  • 2006 Mar;4(1):11-15.
The aim of this study is to identify hRad21-binding sites in human chromosome, the core component of cohesin complex that held sister chromatids together. After chromatin immunoprecipitation with an hRad21...
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The Impact of Transposable Elements in Genome Evolution and Genetic Instability and Their Implications in Various Diseases

Ayarpadikannan S, Kim HS

Approximately 45% of the human genome is comprised of transposable elements (TEs). Results from the Human Genome Project have emphasized the biological importance of TEs. Many studies have revealed that...
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A Case of Malignant Mixed Mullerian Tumor of the Uterus

Yoo HR, Min BS, Park YH, Jang PR

  • KMID: 2244952
  • Korean J Gynecol Oncol Colposc.
  • 2002 Jun;13(2):177-181.
The malignant mixed m illerian tumor (MMMT) of the uterus, a neoplasm composed of both epithelial and stromal elements, is uncommon and highly malignant. It is usually aggressive and advanced...
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Idiopathic Spinal Epidural Lipomatosis

Han YM, Ahn MS

  • KMID: 2067677
  • J Korean Neurosurg Soc.
  • 2001 Jun;30(6):795-799.
Spinal epidural lipomatosis, which causes symptomatic compression of neural elements, is a relatively uncommon disease. Although it has been reported frequently in association with the administration of exogenous steroids, a...
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Structural Variation of Alu Element and Human Disease

Kim S, Cho CS, Han K, Lee J

Transposable elements are one of major sources to cause genomic instability through various mechanisms including de novo insertion, insertion-mediated genomic deletion, and recombination-associated genomic deletion. Among them is Alu element...
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Understanding of epigenetics and dna methylation

Oh JH, Ichiro N

  • KMID: 1485266
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2008 Mar;30(2):205-212.
Genetic variation in the human genome occurs on various levels; from the single nucleotide polymorphism to large, microscopically visible chromosome anomalies. It can be present in many forms, including...
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Molecular Diversity of vanA Gene Cluster in Vancomycin-resistant Enterococci Isolated in One University Hospital

Kim J, Lee JH, Yoon JJ, Lee NY

  • KMID: 2285139
  • Infect Chemother.
  • 2003 Dec;35(6):377-384.
BACKGROUND: The vanA gene is the most frequently encountered gene among isolates, causing vancomycin-resistant Enterococci (VRE) infections in humans, and it is part of the transposable element Tn1546. Knowledge of...
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Molecular Characterization of vanA-containing Enterococcus faecium Isolated from a Teaching Hospital

Lee WG, Lee SH, Lee SM, Huh JY, Yong D, Lee K, Shin WS, Lee DG

  • KMID: 1611052
  • Korean J Clin Microbiol.
  • 2003 Sep;6(2):119-125.
BACKGROUND: The widespread dissemination of Tn1546 has been attributed to transposition into plasmid or transferable elements. The transposition has been achieved through the activity of insertion sequences. Genetic diversity in...
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Comparison of Tn1546-like Elements in vanA Genotype Enterococcus gallinarum and E. faecalis or E. faecium

Lee H, Koh EM, Kim MS, Yum JH, Yong D, Lee WG, Lee K, Chong Y

  • KMID: 2300454
  • Korean J Clin Microbiol.
  • 2007 Oct;10(2):114-118.
BACKGROUND: Enterococcus gallinarum, an organism often found in the intestine, is intrinsically resistant to low level vancomycin, but some of them are highly resistant to vancomycin due to acquisition of...
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Epidemiology and Molecular Characterization of Vancomycin-Resistant Enterococcus faecalis

Kim J, Choi KH, Kim YS, Lee WG

BACKGROUND: Vancomycin-resistant Enterococci (VRE) infections are caused by Enterococcus faecium in about 90% of the cases but can also be caused by Enterococcus faecalis. Thus, this study investigates factors that...
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Molecular Strain Typing of Mycobacterium tuberculosis: a Review of Frequently Used Methods

Ei PW, Aung WW, Lee JS, Choi GE, Chang CL

Tuberculosis, caused by the bacterium Mycobacterium tuberculosis, remains one of the most serious global health problems. Molecular typing of M. tuberculosis has been used for various epidemiologic purposes as well...
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Molecular Characterization of Vancomycin-Resistant Enterococci Isolated from Poultry in Korea

Huh JY, Lee SM, Lee SH, Lee WG, Yong D, Lee K, Shin WS, Lee DG

  • KMID: 1611049
  • Korean J Clin Microbiol.
  • 2003 Sep;6(2):114-118.
BACKGROUND: Vancomycin-resistant enterococci (VRE) have been increasingly isolated worldwide as a nosocomial pathogen. In Korea, because avoparcin has been used as a growth promoter in animal feed, vanA-containing enterococci have...
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Comparative Evaluation of Several Gene Targets for Designing a Multiplex-PCR for an Early Diagnosis of Extrapulmonary Tuberculosis

Raj A, Singh N, Gupta KB, Chaudhary , Yadav A, Chaudhary , Agarwal K, Varma-Basil M, Prasad R, Khuller GK, Mehta PK

PURPOSE: Diagnosis of extrapulmonary tuberculosis (EPTB) poses serious challenges. A careful selection of appropriate gene targets is essential for designing a multiplex-polymerase chain reaction (M-PCR) assay. MATERIALS AND METHODS: We compared...
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